The DSF family of quorum sensing signals: diversity, biosynthesis, and turnover
The diffusible signaling factor (DSF)-based quorum sensing (QS) system has emerged as a widely conserved cell–cell communication mechanism in Gram-negative bacteria. Typically, signals from the DSF family are cis-2-unsaturated fatty acids which regulate diverse biological functions. Recently, substa...
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| Format: | Article |
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Elsevier
2017
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| Online Access: | https://eprints.nottingham.ac.uk/40486/ |
| _version_ | 1848796069789433856 |
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| author | Zhou, Lian Zhang, Lian-Hui Cámara, Miguel He, Ya-Wen |
| author_facet | Zhou, Lian Zhang, Lian-Hui Cámara, Miguel He, Ya-Wen |
| author_sort | Zhou, Lian |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The diffusible signaling factor (DSF)-based quorum sensing (QS) system has emerged as a widely conserved cell–cell communication mechanism in Gram-negative bacteria. Typically, signals from the DSF family are cis-2-unsaturated fatty acids which regulate diverse biological functions. Recently, substantial progress has been made on the characterization of new members of this family of signals. There have also been new developments in the understanding of the biosynthesis of these molecules where dual enzymatic activities of the DSF synthase and the use of various substrates have been described. The recent discovery of a naturally occurring DSF turnover mechanism and its regulation provides a new dimension in our understanding of how DSF-dependent microorganisms modulate virulence gene expression in response to changes in the surrounding environment. |
| first_indexed | 2025-11-14T19:42:07Z |
| format | Article |
| id | nottingham-40486 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:42:07Z |
| publishDate | 2017 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-404862020-05-04T18:40:37Z https://eprints.nottingham.ac.uk/40486/ The DSF family of quorum sensing signals: diversity, biosynthesis, and turnover Zhou, Lian Zhang, Lian-Hui Cámara, Miguel He, Ya-Wen The diffusible signaling factor (DSF)-based quorum sensing (QS) system has emerged as a widely conserved cell–cell communication mechanism in Gram-negative bacteria. Typically, signals from the DSF family are cis-2-unsaturated fatty acids which regulate diverse biological functions. Recently, substantial progress has been made on the characterization of new members of this family of signals. There have also been new developments in the understanding of the biosynthesis of these molecules where dual enzymatic activities of the DSF synthase and the use of various substrates have been described. The recent discovery of a naturally occurring DSF turnover mechanism and its regulation provides a new dimension in our understanding of how DSF-dependent microorganisms modulate virulence gene expression in response to changes in the surrounding environment. Elsevier 2017-04-01 Article PeerReviewed Zhou, Lian, Zhang, Lian-Hui, Cámara, Miguel and He, Ya-Wen (2017) The DSF family of quorum sensing signals: diversity, biosynthesis, and turnover. Trends in Microbiology, 25 (4). pp. 293-303. ISSN 1878-4380 Quorum sensing DSF Biosynthesis Naturally occurring signal turnover Xanthomonas http://dx.doi.org/10.1016/j.tim.2016.11.013 doi:10.1016/j.tim.2016.11.013 doi:10.1016/j.tim.2016.11.013 |
| spellingShingle | Quorum sensing DSF Biosynthesis Naturally occurring signal turnover Xanthomonas Zhou, Lian Zhang, Lian-Hui Cámara, Miguel He, Ya-Wen The DSF family of quorum sensing signals: diversity, biosynthesis, and turnover |
| title | The DSF family of quorum sensing signals: diversity, biosynthesis, and turnover |
| title_full | The DSF family of quorum sensing signals: diversity, biosynthesis, and turnover |
| title_fullStr | The DSF family of quorum sensing signals: diversity, biosynthesis, and turnover |
| title_full_unstemmed | The DSF family of quorum sensing signals: diversity, biosynthesis, and turnover |
| title_short | The DSF family of quorum sensing signals: diversity, biosynthesis, and turnover |
| title_sort | dsf family of quorum sensing signals: diversity, biosynthesis, and turnover |
| topic | Quorum sensing DSF Biosynthesis Naturally occurring signal turnover Xanthomonas |
| url | https://eprints.nottingham.ac.uk/40486/ https://eprints.nottingham.ac.uk/40486/ https://eprints.nottingham.ac.uk/40486/ |