Effect of ethnicity on live birth rates after in vitro fertilisation/intracytoplasmic sperm injection treatment: analysis of UK national database
Objective To evaluate the effect of ethnicity of women on the outcome of in vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI) treatment. Design Observational cohort study. Setting UK National Database. Population Data from 2000 to 2010 involving 38 709 women u...
| Main Authors: | , , , |
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| Format: | Article |
| Published: |
Wiley
2016
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| Online Access: | https://eprints.nottingham.ac.uk/40379/ |
| _version_ | 1848796042372317184 |
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| author | Maalouf, Walid E. Maalouf, Wadih Campbell, Bruce Jayaprakasan, K. |
| author_facet | Maalouf, Walid E. Maalouf, Wadih Campbell, Bruce Jayaprakasan, K. |
| author_sort | Maalouf, Walid E. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Objective
To evaluate the effect of ethnicity of women on the outcome of in vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI) treatment.
Design
Observational cohort study.
Setting
UK National Database.
Population
Data from 2000 to 2010 involving 38 709 women undergoing their first IVF/ICSI cycle were analysed.
Methods
Anonymous data were obtained from the Human Fertilization and Embryology Authority (HFEA), the statutory regulator of IVF and ICSI treatment in the UK. Data analysis was performed by regression analysis with adjustment for age, cause and type of infertility and treatment type (IVF or ICSI) to express results as odds ratio (OR) and 95% confidence intervals (95% CI).
Methods
Live birth rate per cycle of IVF or ICSI treatment.
Results
While white Irish (OR 0.73; 95% CI 0.60–0.90), Indian (0.85; 0.75–0.97), Bangladeshi (0.53: 0.33–0.85), Pakistani (0.68; 0.58–0.80), Black African (0.60; 0.51–0.72), and other non-Caucasian Asian (0.86; 0.73–0.99) had a significantly lower odds of live birth rates per fresh IVF/ICSI cycle than White British women, ethnic groups of White European (1.04; 0.96–1.13), Chinese (1.12; 0.77–1.64), Black Caribbean (0.76; 0.51–1.13), Middle Eastern (0.73; 0.51–1.04), Mediterranean European (1.18; 0.83–1.70) and Mixed race population (0.94; 0.73–1.19) had live birth rates that did not differ significantly. The cumulative live birth rates showed similar patterns across different ethnic groups.
Conclusion
Ethnicity is a major determinant of IVF/ICSI treatment outcome as indicated by significantly lower live birth rates in some of the ethnic minority groups compared with white British women. |
| first_indexed | 2025-11-14T19:41:41Z |
| format | Article |
| id | nottingham-40379 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:41:41Z |
| publishDate | 2016 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-403792020-05-04T18:06:26Z https://eprints.nottingham.ac.uk/40379/ Effect of ethnicity on live birth rates after in vitro fertilisation/intracytoplasmic sperm injection treatment: analysis of UK national database Maalouf, Walid E. Maalouf, Wadih Campbell, Bruce Jayaprakasan, K. Objective To evaluate the effect of ethnicity of women on the outcome of in vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI) treatment. Design Observational cohort study. Setting UK National Database. Population Data from 2000 to 2010 involving 38 709 women undergoing their first IVF/ICSI cycle were analysed. Methods Anonymous data were obtained from the Human Fertilization and Embryology Authority (HFEA), the statutory regulator of IVF and ICSI treatment in the UK. Data analysis was performed by regression analysis with adjustment for age, cause and type of infertility and treatment type (IVF or ICSI) to express results as odds ratio (OR) and 95% confidence intervals (95% CI). Methods Live birth rate per cycle of IVF or ICSI treatment. Results While white Irish (OR 0.73; 95% CI 0.60–0.90), Indian (0.85; 0.75–0.97), Bangladeshi (0.53: 0.33–0.85), Pakistani (0.68; 0.58–0.80), Black African (0.60; 0.51–0.72), and other non-Caucasian Asian (0.86; 0.73–0.99) had a significantly lower odds of live birth rates per fresh IVF/ICSI cycle than White British women, ethnic groups of White European (1.04; 0.96–1.13), Chinese (1.12; 0.77–1.64), Black Caribbean (0.76; 0.51–1.13), Middle Eastern (0.73; 0.51–1.04), Mediterranean European (1.18; 0.83–1.70) and Mixed race population (0.94; 0.73–1.19) had live birth rates that did not differ significantly. The cumulative live birth rates showed similar patterns across different ethnic groups. Conclusion Ethnicity is a major determinant of IVF/ICSI treatment outcome as indicated by significantly lower live birth rates in some of the ethnic minority groups compared with white British women. Wiley 2016-08-19 Article PeerReviewed Maalouf, Walid E., Maalouf, Wadih, Campbell, Bruce and Jayaprakasan, K. (2016) Effect of ethnicity on live birth rates after in vitro fertilisation/intracytoplasmic sperm injection treatment: analysis of UK national database. BJOG: An International Journal of Obstetrics and Gynaecology . ISSN 1471-0528 Ethnicity Infertility Assisted conception IVF ICSI Live birth Embryo http://dx.doi.org/10.1111/1471-0528.14241 doi:10.1111/1471-0528.14241 doi:10.1111/1471-0528.14241 |
| spellingShingle | Ethnicity Infertility Assisted conception IVF ICSI Live birth Embryo Maalouf, Walid E. Maalouf, Wadih Campbell, Bruce Jayaprakasan, K. Effect of ethnicity on live birth rates after in vitro fertilisation/intracytoplasmic sperm injection treatment: analysis of UK national database |
| title | Effect of ethnicity on live birth rates after in vitro fertilisation/intracytoplasmic sperm injection treatment: analysis of UK national database |
| title_full | Effect of ethnicity on live birth rates after in vitro fertilisation/intracytoplasmic sperm injection treatment: analysis of UK national database |
| title_fullStr | Effect of ethnicity on live birth rates after in vitro fertilisation/intracytoplasmic sperm injection treatment: analysis of UK national database |
| title_full_unstemmed | Effect of ethnicity on live birth rates after in vitro fertilisation/intracytoplasmic sperm injection treatment: analysis of UK national database |
| title_short | Effect of ethnicity on live birth rates after in vitro fertilisation/intracytoplasmic sperm injection treatment: analysis of UK national database |
| title_sort | effect of ethnicity on live birth rates after in vitro fertilisation/intracytoplasmic sperm injection treatment: analysis of uk national database |
| topic | Ethnicity Infertility Assisted conception IVF ICSI Live birth Embryo |
| url | https://eprints.nottingham.ac.uk/40379/ https://eprints.nottingham.ac.uk/40379/ https://eprints.nottingham.ac.uk/40379/ |