Physiological roles of macrophages
Macrophages are present in mammals from midgestation, contributing to physiologic homeostasis throughout life. Macrophages arise from yolk sac and foetal liver progenitors during embryonic development in the mouse and persist in different organs as heterogeneous, self-renewing tissue-resident popula...
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| Format: | Article |
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Springer Verlag
2017
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| Online Access: | https://eprints.nottingham.ac.uk/40317/ |
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| author | Gordon, Siamon Martinez-Pomares, Luisa |
| author_facet | Gordon, Siamon Martinez-Pomares, Luisa |
| author_sort | Gordon, Siamon |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Macrophages are present in mammals from midgestation, contributing to physiologic homeostasis throughout life. Macrophages arise from yolk sac and foetal liver progenitors during embryonic development in the mouse and persist in different organs as heterogeneous, self-renewing tissue-resident populations. Bone marrow-derived blood monocytes are recruited after birth to replenish tissue-resident populations and to meet further demands during inflammation, infection and metabolic perturbations. Macrophages of mixed origin and different locations vary in replication and turnover, but are all active in mRNA and protein synthesis, fulfilling organ-specific and systemic trophic functions, in addition to host defence. In this review we emphasise selected properties and non-immune functions of tissue macrophages which contribute to physiologic homeostasis. |
| first_indexed | 2025-11-14T19:41:27Z |
| format | Article |
| id | nottingham-40317 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:41:27Z |
| publishDate | 2017 |
| publisher | Springer Verlag |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-403172020-05-04T18:35:23Z https://eprints.nottingham.ac.uk/40317/ Physiological roles of macrophages Gordon, Siamon Martinez-Pomares, Luisa Macrophages are present in mammals from midgestation, contributing to physiologic homeostasis throughout life. Macrophages arise from yolk sac and foetal liver progenitors during embryonic development in the mouse and persist in different organs as heterogeneous, self-renewing tissue-resident populations. Bone marrow-derived blood monocytes are recruited after birth to replenish tissue-resident populations and to meet further demands during inflammation, infection and metabolic perturbations. Macrophages of mixed origin and different locations vary in replication and turnover, but are all active in mRNA and protein synthesis, fulfilling organ-specific and systemic trophic functions, in addition to host defence. In this review we emphasise selected properties and non-immune functions of tissue macrophages which contribute to physiologic homeostasis. Springer Verlag 2017-02-09 Article PeerReviewed Gordon, Siamon and Martinez-Pomares, Luisa (2017) Physiological roles of macrophages. Pflügers Archiv European Journal of Physiology . pp. 1-10. ISSN 1432-2013 Macrophages Homeostasis Tissue heterogeneity Physiology Receptors Phagocytosis http://link.springer.com/article/10.1007%2Fs00424-017-1945-7 doi:10.1007/s00424-017-1945-7 doi:10.1007/s00424-017-1945-7 |
| spellingShingle | Macrophages Homeostasis Tissue heterogeneity Physiology Receptors Phagocytosis Gordon, Siamon Martinez-Pomares, Luisa Physiological roles of macrophages |
| title | Physiological roles of macrophages |
| title_full | Physiological roles of macrophages |
| title_fullStr | Physiological roles of macrophages |
| title_full_unstemmed | Physiological roles of macrophages |
| title_short | Physiological roles of macrophages |
| title_sort | physiological roles of macrophages |
| topic | Macrophages Homeostasis Tissue heterogeneity Physiology Receptors Phagocytosis |
| url | https://eprints.nottingham.ac.uk/40317/ https://eprints.nottingham.ac.uk/40317/ https://eprints.nottingham.ac.uk/40317/ |