Disease and pharmacologic risk factors for first and subsequent episodes of equine laminitis: a cohort study of free-text electronic medical records
Electronic medical records from first opinion equine veterinary practice may represent a unique resource for epidemiologic research. The appropriateness of this resource for risk factor analyses was explored as part of an investigation into clinical and pharmacologic risk factors for laminitis. Amal...
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| Format: | Article |
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Elsevier
2017
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| Online Access: | https://eprints.nottingham.ac.uk/40315/ |
| _version_ | 1848796026821935104 |
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| author | Welsh, Claire E. Duz, Marco Parkin, Timothy D.H. Marshall, John F. |
| author_facet | Welsh, Claire E. Duz, Marco Parkin, Timothy D.H. Marshall, John F. |
| author_sort | Welsh, Claire E. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Electronic medical records from first opinion equine veterinary practice may represent a unique resource for epidemiologic research. The appropriateness of this resource for risk factor analyses was explored as part of an investigation into clinical and pharmacologic risk factors for laminitis. Amalgamated medical records from seven UK practices were subjected to text mining to identify laminitis episodes, systemic or intra-synovial corticosteroid prescription, diseases known to affect laminitis risk and clinical signs or syndromes likely to lead to corticosteroid use. Cox proportional hazard models and Prentice, Williams, Peterson models for repeated events were used to estimate associations with time to first, or subsequent laminitis episodes, respectively. Over seventy percent of horses that were diagnosed with laminitis suf- fered at least one recurrence. Risk factors for first and subsequent laminitis episodes were found to vary. Corticosteroid use (prednisolone only) was only significantly associated with subsequent, and not ini- tial laminitis episodes. Electronic medical record use for such analyses is plausible and offers important advantages over more traditional data sources. It does, however, pose challenges and limitations that must be taken into account, and requires a conceptual change to disease diagnosis which should be considered carefully. |
| first_indexed | 2025-11-14T19:41:26Z |
| format | Article |
| id | nottingham-40315 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:41:26Z |
| publishDate | 2017 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-403152020-05-04T18:23:15Z https://eprints.nottingham.ac.uk/40315/ Disease and pharmacologic risk factors for first and subsequent episodes of equine laminitis: a cohort study of free-text electronic medical records Welsh, Claire E. Duz, Marco Parkin, Timothy D.H. Marshall, John F. Electronic medical records from first opinion equine veterinary practice may represent a unique resource for epidemiologic research. The appropriateness of this resource for risk factor analyses was explored as part of an investigation into clinical and pharmacologic risk factors for laminitis. Amalgamated medical records from seven UK practices were subjected to text mining to identify laminitis episodes, systemic or intra-synovial corticosteroid prescription, diseases known to affect laminitis risk and clinical signs or syndromes likely to lead to corticosteroid use. Cox proportional hazard models and Prentice, Williams, Peterson models for repeated events were used to estimate associations with time to first, or subsequent laminitis episodes, respectively. Over seventy percent of horses that were diagnosed with laminitis suf- fered at least one recurrence. Risk factors for first and subsequent laminitis episodes were found to vary. Corticosteroid use (prednisolone only) was only significantly associated with subsequent, and not ini- tial laminitis episodes. Electronic medical record use for such analyses is plausible and offers important advantages over more traditional data sources. It does, however, pose challenges and limitations that must be taken into account, and requires a conceptual change to disease diagnosis which should be considered carefully. Elsevier 2017-01-01 Article PeerReviewed Welsh, Claire E., Duz, Marco, Parkin, Timothy D.H. and Marshall, John F. (2017) Disease and pharmacologic risk factors for first and subsequent episodes of equine laminitis: a cohort study of free-text electronic medical records. Preventive Veterinary Medicine, 136 . pp. 11-18. ISSN 0167-5877 laminitis horse electronic medical records text mining http://www.sciencedirect.com/science/article/pii/S0167587716305815 doi:10.1016/j.prevetmed.2016.11.012 doi:10.1016/j.prevetmed.2016.11.012 |
| spellingShingle | laminitis horse electronic medical records text mining Welsh, Claire E. Duz, Marco Parkin, Timothy D.H. Marshall, John F. Disease and pharmacologic risk factors for first and subsequent episodes of equine laminitis: a cohort study of free-text electronic medical records |
| title | Disease and pharmacologic risk factors for first and subsequent episodes of equine laminitis: a cohort study of free-text electronic medical records |
| title_full | Disease and pharmacologic risk factors for first and subsequent episodes of equine laminitis: a cohort study of free-text electronic medical records |
| title_fullStr | Disease and pharmacologic risk factors for first and subsequent episodes of equine laminitis: a cohort study of free-text electronic medical records |
| title_full_unstemmed | Disease and pharmacologic risk factors for first and subsequent episodes of equine laminitis: a cohort study of free-text electronic medical records |
| title_short | Disease and pharmacologic risk factors for first and subsequent episodes of equine laminitis: a cohort study of free-text electronic medical records |
| title_sort | disease and pharmacologic risk factors for first and subsequent episodes of equine laminitis: a cohort study of free-text electronic medical records |
| topic | laminitis horse electronic medical records text mining |
| url | https://eprints.nottingham.ac.uk/40315/ https://eprints.nottingham.ac.uk/40315/ https://eprints.nottingham.ac.uk/40315/ |