The cardiovascular profile and pharmacology of vandetanib and pazopanib
Angiogenesis, a process that enables the growth of blood vessels from a pre-existing vasculature and is common to all solid tumours greater than 1 mm3 in size (Gacche and Meshram, 2014). The angiogenic process is heavily promoted by vascular endothelial growth factor (VEGF). Compounds able to inhibi...
| Main Author: | Carter, Joanne |
|---|---|
| Format: | Thesis (University of Nottingham only) |
| Language: | English |
| Published: |
2017
|
| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/40191/ |
Similar Items
Molecular pharmacology of VEGF-A isoforms: binding and signalling at VEGFR2
by: Peach, Chloe, et al.
Published: (2018)
by: Peach, Chloe, et al.
Published: (2018)
Control of collateral formation as a therapeutic for cardiovascular disease
by: Amartey, Jason
Published: (2024)
by: Amartey, Jason
Published: (2024)
Decitabine-Vorinostat combination treatment in acute myeloid leukemia activates pathways with potential for novel triple therapy
by: Young, Christine S., et al.
Published: (2017)
by: Young, Christine S., et al.
Published: (2017)
Real-time analysis of the binding of fluorescent VEGF₁₆₅a to VEGFR2 in living cells: Effect of receptor tyrosine kinase inhibitors and fate of internalized agonist-receptor complexes
by: Kilpatrick, Laura E., et al.
Published: (2017)
by: Kilpatrick, Laura E., et al.
Published: (2017)
A phase 2 trial of decreasing tyrosine kinase inhibitor dose in chronic myeloid leukaemia patients with stable major molecular response: data from the British DESTINY study
by: Clark, Richard E., et al.
Published: (2017)
by: Clark, Richard E., et al.
Published: (2017)
Altered ratios of pro- and anti-angiogenic VEGF-A variants and pericyte expression of DLL4 disrupt the vascular maturation in infantile haemangioma
by: Ye, Xi, et al.
Published: (2016)
by: Ye, Xi, et al.
Published: (2016)
Elucidation of basic mechanisms of flavokawin B inhibitory effects on the growth of selected cancer and transformed normal cell lines
by: Umar, Nasir Tsafe
Published: (2008)
by: Umar, Nasir Tsafe
Published: (2008)
Development of existing and novel tyrosinase inhibitors for skin pigmentation: intradermal delivery, biological evaluation and mechanistic studies
by: Li, Zhiwei
Published: (2023)
by: Li, Zhiwei
Published: (2023)
Use of SRPK1 inhibitors for the treatment of Diabetic Retinopathy
by: Malhi, Naseeb
Published: (2021)
by: Malhi, Naseeb
Published: (2021)
Pre-eclampsia: the role of vascular endothelial growth factor and its interaction with the vascular endothelium
by: Brockelsby, Jeremy Charles
Published: (2001)
by: Brockelsby, Jeremy Charles
Published: (2001)
VEGF-A165b protects against proteinuria in a mouse model with progressive depletion of all endogenous VEGF-A splice isoforms from the kidney
by: Stevens, Megan, et al.
Published: (2017)
by: Stevens, Megan, et al.
Published: (2017)
Role of RhoGDIα on migration and invasion of estrogen receptor positive MCF7 and estrogen receptor negative MDA-MB-231 breast cancer cells
by: Hooshmand, Somayeh
Published: (2014)
by: Hooshmand, Somayeh
Published: (2014)
Effects of omentin on endothelial disruption and hydrogen peroxide-induced inflammation in vascular endothelial cell monolayer
by: Kamaruddin, Nur Aqilah
Published: (2022)
by: Kamaruddin, Nur Aqilah
Published: (2022)
Myocardial infarction after intravitreal vascular endothelial growth factor inhibitors: a whole population study
by: Kemp, A., et al.
Published: (2013)
by: Kemp, A., et al.
Published: (2013)
The cardiovascular and functional consequences of arteriovenous fistula formation in chronic kidney disease
by: Korsheed, Shvan
Published: (2011)
by: Korsheed, Shvan
Published: (2011)
Gene therapy using plasmid DNA encoding vascular endothelial growth factor 164 and fibroblast growth factor 2 genes for the treatment of horse tendinitis and desmitis: case reports
by: Kovac, Milomir, et al.
Published: (2017)
by: Kovac, Milomir, et al.
Published: (2017)
Peripheral contributions to the development and maintenance of inflammation and pain in arthritis
by: Amanitis, Dimitrios
Published: (2022)
by: Amanitis, Dimitrios
Published: (2022)
Cardiovascular safety liabilities of VEGFR-2 inhibitors
by: Pannucci, Patrizia
Published: (2024)
by: Pannucci, Patrizia
Published: (2024)
Survivin and AURKA, key determinants of mitotic cell fate
by: Abdelkabir, Hana
Published: (2024)
by: Abdelkabir, Hana
Published: (2024)
Molecular cloning, functional assessment and transcriptome characterization of cysteine protease inhibitor and kunitz trypsin inhibitor from turmeric (Curcuma longa L.)
by: Chan, Seow Neng
Published: (2016)
by: Chan, Seow Neng
Published: (2016)
Tobramycin and gentamicin-incorporated calcium phosphate beads as delivery system in prevention of Staphylococcus aureus biofilm formation
by: Che Seman, Che Nor Zarida
Published: (2012)
by: Che Seman, Che Nor Zarida
Published: (2012)
Effects of hypoxia and hyperoxia on the differential expression of VEGF-A isoforms and receptors in Idiopathic Pulmonary Fibrosis (IPF)
by: Barratt, Shaney L., et al.
Published: (2018)
by: Barratt, Shaney L., et al.
Published: (2018)
Design and synthesis of small molecule inhibitors of coagulation FXIIa
by: Chen, Xi
Published: (2018)
by: Chen, Xi
Published: (2018)
Discovery of highly potent and selective phosphatidylinositol 3-kinase-δ inhibitors for the treatment of blood cancers and autoimmune diseases
by: Buzrieda, Anas
Published: (2021)
by: Buzrieda, Anas
Published: (2021)
Alternative splicing and the inhibition of splicing kinases in Alzheimer’s Disease
by: Alalwany, Roaa
Published: (2021)
by: Alalwany, Roaa
Published: (2021)
Identification of lipase inhibitor from orthosiphon stamineus benth and analysis of lipase-inhibitor complex interaction
by: Alias, Norsyuhada
Published: (2016)
by: Alias, Norsyuhada
Published: (2016)
The effect of gestational diabetes on human umbilical mesenchymal stem cells and their ability to influence endothelial permeability
by: Salem, Samar
Published: (2023)
by: Salem, Samar
Published: (2023)
PCBs and heavy metals in fish and shellfish, dietary exposure and neurobehavioral performance among Malaysian fishermen
by: Mohamad, Alina
Published: (2011)
by: Mohamad, Alina
Published: (2011)
Mitogen-activated protein/extracellular signal-regulated kinase kinase 1act/tubulin interaction is an important determinant of mitotic stability in cultured HT1080 human fibrosarcoma cells.
by: Cao, Jia-ning, et al.
Published: (2010)
by: Cao, Jia-ning, et al.
Published: (2010)
Approved and experimental small-molecule oncology kinase inhibitor drugs: a mid-2016 overview
by: Fischer, Peter M.
Published: (2017)
by: Fischer, Peter M.
Published: (2017)
Association of Statin Use With Disability-Free Survival and Cardiovascular Disease Among Healthy Older Adults
by: Zhou, Z., et al.
Published: (2020)
by: Zhou, Z., et al.
Published: (2020)
Investigating bisubstrate inhibitors of PRMT1 and CARM1
by: Gunnell, Emma
Published: (2019)
by: Gunnell, Emma
Published: (2019)
PHARMACOLOGICAL EVALUATION OF NOVEL COMPOUNDS AS ALZHEIMER’S DISEASE TREATMENT
by: Li, Tian-Tian
Published: (2024)
by: Li, Tian-Tian
Published: (2024)
Synthesis and investigation of anti-tyrosinase and antioxidant activity of new halogenated xanthone derivatives
by: Baharuddin, Fatin Farhana
Published: (2023)
by: Baharuddin, Fatin Farhana
Published: (2023)
Development of quinone-rich fraction of Ardisia crispa (Thunb.) A.DC roots mitigates rheumatoid arthritis by suppressing angiogenesis, in vitro and in vivo
by: Blin, Joan
Published: (2021)
by: Blin, Joan
Published: (2021)
Preparation of potent and selective αvβ6 integrin inhibitors for the treatment of idiopathic pulmonary fibrosis and synthetic approaches towards the total synthesis of mescengricin
by: Robinson, Henry Duncan
Published: (2021)
by: Robinson, Henry Duncan
Published: (2021)
Identification of genes and pathways regulated by the PRH/HHEX transcription factor in endothelial and lymphatic cells
by: Dahhan, Rania
Published: (2024)
by: Dahhan, Rania
Published: (2024)
Protein Kinase C-Delta C2 Domain Interactions in Breast Cancer
by: Khader, Rasha
Published: (2023)
by: Khader, Rasha
Published: (2023)
The role of calpain/calpastatin in breast cancer
by: Cook, Liam
Published: (2024)
by: Cook, Liam
Published: (2024)
Can an inhibitor of a multidrug pump become a substrate?
by: Hutchison, Ella
Published: (2022)
by: Hutchison, Ella
Published: (2022)
Similar Items
-
Molecular pharmacology of VEGF-A isoforms: binding and signalling at VEGFR2
by: Peach, Chloe, et al.
Published: (2018) -
Control of collateral formation as a therapeutic for cardiovascular disease
by: Amartey, Jason
Published: (2024) -
Decitabine-Vorinostat combination treatment in acute myeloid leukemia activates pathways with potential for novel triple therapy
by: Young, Christine S., et al.
Published: (2017) -
Real-time analysis of the binding of fluorescent VEGF₁₆₅a to VEGFR2 in living cells: Effect of receptor tyrosine kinase inhibitors and fate of internalized agonist-receptor complexes
by: Kilpatrick, Laura E., et al.
Published: (2017) -
A phase 2 trial of decreasing tyrosine kinase inhibitor dose in chronic myeloid leukaemia patients with stable major molecular response: data from the British DESTINY study
by: Clark, Richard E., et al.
Published: (2017)