Traditional and emerging indicators of cardiovascular risk in chronic obstructive pulmonary disease
With the increased cardiovascular (CV) morbidity and mortality in subjects with chronic obstructive pulmonary disease (COPD), there is a priority to identify those patients at increased risk of cardiovascular disease. Stable patients with COPD (n = 185) and controls with a smoking history (n = 106)...
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SAGE Publications
2016
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| Online Access: | https://eprints.nottingham.ac.uk/40147/ |
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| author | John, Michelle McKeever, Tricia M. Haddad, Maath Al Hall, Ian P. Sayers, Ian Cockcroft, John R. Bolton, Charlotte E. |
| author_facet | John, Michelle McKeever, Tricia M. Haddad, Maath Al Hall, Ian P. Sayers, Ian Cockcroft, John R. Bolton, Charlotte E. |
| author_sort | John, Michelle |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | With the increased cardiovascular (CV) morbidity and mortality in subjects with chronic obstructive pulmonary disease (COPD), there is a priority to identify those patients at increased risk of cardiovascular disease. Stable patients with COPD (n = 185) and controls with a smoking history (n = 106) underwent aortic pulse wave velocity (PWV), blood pressure (BP) and skin autofluorescence (AF) at clinical stability. Blood was sent for fasting lipids, soluble receptor for advanced glycation end products (sRAGE) and CV risk prediction scores were calculated. More patients (18%) had a self-reported history of CV disease than controls (8%), p = 0.02, whilst diabetes was similar (14% and 10%), p = 0.44. Mean (SD) skin AF was greater in patients: 3.1 (0.5) AU than controls 2.8 (0.6) AU, p < 0.001. Aortic PWV was greater in patients: 10.2 (2.3) m/s than controls: 9.6 (2.0) m/s, p = 0.02 despite similar BP. The CV risk prediction scores did not differentiate between patients and controls nor were the individual components of the scores different. The sRAGE levels were not statistically different. We present different indicators of CV risk alongside each other in well-defined subjects with and without COPD. Two non-invasive biomarkers associated with future CV burden: skin AF and aortic PWV are both significantly greater in patients with COPD compared to the controls. The traditional CV prediction scores used in the general population were not statistically different. We provide new data to suggest that alternative approaches for optimal CV risk detection should be employed in COPD management. |
| first_indexed | 2025-11-14T19:40:56Z |
| format | Article |
| id | nottingham-40147 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:40:56Z |
| publishDate | 2016 |
| publisher | SAGE Publications |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-401472020-05-04T17:58:25Z https://eprints.nottingham.ac.uk/40147/ Traditional and emerging indicators of cardiovascular risk in chronic obstructive pulmonary disease John, Michelle McKeever, Tricia M. Haddad, Maath Al Hall, Ian P. Sayers, Ian Cockcroft, John R. Bolton, Charlotte E. With the increased cardiovascular (CV) morbidity and mortality in subjects with chronic obstructive pulmonary disease (COPD), there is a priority to identify those patients at increased risk of cardiovascular disease. Stable patients with COPD (n = 185) and controls with a smoking history (n = 106) underwent aortic pulse wave velocity (PWV), blood pressure (BP) and skin autofluorescence (AF) at clinical stability. Blood was sent for fasting lipids, soluble receptor for advanced glycation end products (sRAGE) and CV risk prediction scores were calculated. More patients (18%) had a self-reported history of CV disease than controls (8%), p = 0.02, whilst diabetes was similar (14% and 10%), p = 0.44. Mean (SD) skin AF was greater in patients: 3.1 (0.5) AU than controls 2.8 (0.6) AU, p < 0.001. Aortic PWV was greater in patients: 10.2 (2.3) m/s than controls: 9.6 (2.0) m/s, p = 0.02 despite similar BP. The CV risk prediction scores did not differentiate between patients and controls nor were the individual components of the scores different. The sRAGE levels were not statistically different. We present different indicators of CV risk alongside each other in well-defined subjects with and without COPD. Two non-invasive biomarkers associated with future CV burden: skin AF and aortic PWV are both significantly greater in patients with COPD compared to the controls. The traditional CV prediction scores used in the general population were not statistically different. We provide new data to suggest that alternative approaches for optimal CV risk detection should be employed in COPD management. SAGE Publications 2016-08-01 Article PeerReviewed John, Michelle, McKeever, Tricia M., Haddad, Maath Al, Hall, Ian P., Sayers, Ian, Cockcroft, John R. and Bolton, Charlotte E. (2016) Traditional and emerging indicators of cardiovascular risk in chronic obstructive pulmonary disease. Chronic Respiratory Disease, 13 (3). pp. 247-255. ISSN 1479-9731 Cardiovascular risk COPD Advanced glycation end products Aortic stiffness Autofluorescence http://journals.sagepub.com/doi/abs/10.1177/1479972316636995 doi:10.1177/1479972316636995 doi:10.1177/1479972316636995 |
| spellingShingle | Cardiovascular risk COPD Advanced glycation end products Aortic stiffness Autofluorescence John, Michelle McKeever, Tricia M. Haddad, Maath Al Hall, Ian P. Sayers, Ian Cockcroft, John R. Bolton, Charlotte E. Traditional and emerging indicators of cardiovascular risk in chronic obstructive pulmonary disease |
| title | Traditional and emerging indicators of cardiovascular risk in chronic obstructive pulmonary disease |
| title_full | Traditional and emerging indicators of cardiovascular risk in chronic obstructive pulmonary disease |
| title_fullStr | Traditional and emerging indicators of cardiovascular risk in chronic obstructive pulmonary disease |
| title_full_unstemmed | Traditional and emerging indicators of cardiovascular risk in chronic obstructive pulmonary disease |
| title_short | Traditional and emerging indicators of cardiovascular risk in chronic obstructive pulmonary disease |
| title_sort | traditional and emerging indicators of cardiovascular risk in chronic obstructive pulmonary disease |
| topic | Cardiovascular risk COPD Advanced glycation end products Aortic stiffness Autofluorescence |
| url | https://eprints.nottingham.ac.uk/40147/ https://eprints.nottingham.ac.uk/40147/ https://eprints.nottingham.ac.uk/40147/ |