Block of nicotinic acetylcholine receptors by philanthotoxins is strongly dependent on their subunit composition

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Block of nicotinic acetylcholine receptors by philanthotoxins is strongly dependent on their subunit composition

Philanthotoxin-433 (PhTX-433) is an active component of the venom from the Egyptian digger wasp, Philanthus triangulum. PhTX-433 inhibits several excitatory ligand-gated ion channels, and to improve selectivity two synthetic analogues, PhTX-343 and PhTX-12, were developed. Previous work showed a 22-...

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Bibliographic Details
Main Authors:	Kachel, Hamid S., Patel, Rohit N., Franzyk, Henrik, Mellor, Ian R.
Format:	Article
Published:	Nature Publishing Group 2016
Online Access:	https://eprints.nottingham.ac.uk/40074/

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