Acetylcholinesterase activity measurement and clinical features of delirium
Aims: Cholinergic deficiency is commonly implicated in the pathophysiology of delirium. We aimed to investigate the relationship between directly measured serum AChE activity and (1) clinical features of delirium and (2) outcomes, among older hospital patients with delirium. Methods: Hospitalized p...
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| Format: | Article |
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Karger
2017
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| Online Access: | https://eprints.nottingham.ac.uk/40070/ |
| _version_ | 1848795978474192896 |
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| author | Jackson, T.A. Moorey, H.C. Sheehan, B. Maclullich, A.M.J. Gladman, J.R.F. Lord, J.M. |
| author_facet | Jackson, T.A. Moorey, H.C. Sheehan, B. Maclullich, A.M.J. Gladman, J.R.F. Lord, J.M. |
| author_sort | Jackson, T.A. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Aims: Cholinergic deficiency is commonly implicated in the pathophysiology of delirium. We aimed to investigate the relationship between directly measured serum AChE activity and (1) clinical features of delirium and (2) outcomes, among older hospital patients with delirium.
Methods: Hospitalized patients with delirium were recruited and delirium motor subtype, severity and duration of delirium were measured. Serum AChE activity was measured using a colorimetric assay.
Results: The mean AChE activity for the whole sample was 2.46 μmol/μml/min (SD 1.75). Higher AChE activity was associated with increased likelihood of hypoactive delirium rather than the hyperactive or mixed subtype (OR 1.98, CI 1.10-3.59).
Conclusion: Higher AChE activity was associated with hypoactive delirium, but did not predict outcomes. Simple enhancement of cholinergic neurotransmission may not be sufficient to treat delirium |
| first_indexed | 2025-11-14T19:40:40Z |
| format | Article |
| id | nottingham-40070 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:40:40Z |
| publishDate | 2017 |
| publisher | Karger |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-400702020-05-04T18:28:13Z https://eprints.nottingham.ac.uk/40070/ Acetylcholinesterase activity measurement and clinical features of delirium Jackson, T.A. Moorey, H.C. Sheehan, B. Maclullich, A.M.J. Gladman, J.R.F. Lord, J.M. Aims: Cholinergic deficiency is commonly implicated in the pathophysiology of delirium. We aimed to investigate the relationship between directly measured serum AChE activity and (1) clinical features of delirium and (2) outcomes, among older hospital patients with delirium. Methods: Hospitalized patients with delirium were recruited and delirium motor subtype, severity and duration of delirium were measured. Serum AChE activity was measured using a colorimetric assay. Results: The mean AChE activity for the whole sample was 2.46 μmol/μml/min (SD 1.75). Higher AChE activity was associated with increased likelihood of hypoactive delirium rather than the hyperactive or mixed subtype (OR 1.98, CI 1.10-3.59). Conclusion: Higher AChE activity was associated with hypoactive delirium, but did not predict outcomes. Simple enhancement of cholinergic neurotransmission may not be sufficient to treat delirium Karger 2017-02-01 Article PeerReviewed Jackson, T.A., Moorey, H.C., Sheehan, B., Maclullich, A.M.J., Gladman, J.R.F. and Lord, J.M. (2017) Acetylcholinesterase activity measurement and clinical features of delirium. Dementia and Geriatric Cognitive Disorders, 43 (1-2). pp. 29-37. ISSN 1421-9824 Acetylcholinesterase activity acetylcholine delirium cholinesterase inhibitors aged delirium motor subtype https://www.karger.com/Article/Abstract/452832 doi:10.1159/000452832 doi:10.1159/000452832 |
| spellingShingle | Acetylcholinesterase activity acetylcholine delirium cholinesterase inhibitors aged delirium motor subtype Jackson, T.A. Moorey, H.C. Sheehan, B. Maclullich, A.M.J. Gladman, J.R.F. Lord, J.M. Acetylcholinesterase activity measurement and clinical features of delirium |
| title | Acetylcholinesterase activity measurement and clinical features of delirium |
| title_full | Acetylcholinesterase activity measurement and clinical features of delirium |
| title_fullStr | Acetylcholinesterase activity measurement and clinical features of delirium |
| title_full_unstemmed | Acetylcholinesterase activity measurement and clinical features of delirium |
| title_short | Acetylcholinesterase activity measurement and clinical features of delirium |
| title_sort | acetylcholinesterase activity measurement and clinical features of delirium |
| topic | Acetylcholinesterase activity acetylcholine delirium cholinesterase inhibitors aged delirium motor subtype |
| url | https://eprints.nottingham.ac.uk/40070/ https://eprints.nottingham.ac.uk/40070/ https://eprints.nottingham.ac.uk/40070/ |