Nitric oxide sensing in plants is mediated by proteolytic control of Group VII ERF transcription factors
Nitric oxide (NO) is an important signaling compound in prokaryotes and eukaryotes. In plants, NO regulates critical developmental transitions and stress responses. Here, we identify a mechanism for NO sensing that coordinates responses throughout development based on targeted degradation of plant-s...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Published: |
Elsevier
2014
|
| Online Access: | https://eprints.nottingham.ac.uk/40042/ |
| _version_ | 1848795974036619264 |
|---|---|
| author | Gibbs, Daniel J. Md Isa, Nurulhikma Movahedi, Mahsa Lozano-Juste, Jorge Mendiondo, Guillermina M. Berckhan, Sophie Marín-de la Rosa, Nora Vicente Conde, Jorge Sousa Correia, Cristina Pearce, Simon P. Bassel, George W. Hamali, Bulut Talloji, Prabhavathi Tomé, Daniel F.A. Coego, Alberto Beynon, Jim Alabadí, David Bachmair, Andreas León, José Gray, Julie E. Theodoulou, Frederica L. Holdsworth, Michael J. |
| author_facet | Gibbs, Daniel J. Md Isa, Nurulhikma Movahedi, Mahsa Lozano-Juste, Jorge Mendiondo, Guillermina M. Berckhan, Sophie Marín-de la Rosa, Nora Vicente Conde, Jorge Sousa Correia, Cristina Pearce, Simon P. Bassel, George W. Hamali, Bulut Talloji, Prabhavathi Tomé, Daniel F.A. Coego, Alberto Beynon, Jim Alabadí, David Bachmair, Andreas León, José Gray, Julie E. Theodoulou, Frederica L. Holdsworth, Michael J. |
| author_sort | Gibbs, Daniel J. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Nitric oxide (NO) is an important signaling compound in prokaryotes and eukaryotes. In plants, NO regulates critical developmental transitions and stress responses. Here, we identify a mechanism for NO sensing that coordinates responses throughout development based on targeted degradation of plant-specific transcriptional regulators, the group VII ethylene response factors (ERFs). We show that the N-end rule pathway of targeted proteolysis targets these proteins for destruction in the presence of NO, and we establish them as critical regulators of diverse NO-regulated processes, including seed germination, stomatal closure, and hypocotyl elongation. Furthermore, we define the molecular mechanism for NO control of germination and crosstalk with abscisic acid (ABA) signaling through ERF-regulated expression of ABSCISIC ACID INSENSITIVE5 (ABI5). Our work demonstrates how NO sensing is integrated across multiple physiological processes by direct modulation of transcription factor stability and identifies group VII ERFs as central hubs for the perception of gaseous signals in plants. |
| first_indexed | 2025-11-14T19:40:36Z |
| format | Article |
| id | nottingham-40042 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:40:36Z |
| publishDate | 2014 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-400422020-05-04T16:43:20Z https://eprints.nottingham.ac.uk/40042/ Nitric oxide sensing in plants is mediated by proteolytic control of Group VII ERF transcription factors Gibbs, Daniel J. Md Isa, Nurulhikma Movahedi, Mahsa Lozano-Juste, Jorge Mendiondo, Guillermina M. Berckhan, Sophie Marín-de la Rosa, Nora Vicente Conde, Jorge Sousa Correia, Cristina Pearce, Simon P. Bassel, George W. Hamali, Bulut Talloji, Prabhavathi Tomé, Daniel F.A. Coego, Alberto Beynon, Jim Alabadí, David Bachmair, Andreas León, José Gray, Julie E. Theodoulou, Frederica L. Holdsworth, Michael J. Nitric oxide (NO) is an important signaling compound in prokaryotes and eukaryotes. In plants, NO regulates critical developmental transitions and stress responses. Here, we identify a mechanism for NO sensing that coordinates responses throughout development based on targeted degradation of plant-specific transcriptional regulators, the group VII ethylene response factors (ERFs). We show that the N-end rule pathway of targeted proteolysis targets these proteins for destruction in the presence of NO, and we establish them as critical regulators of diverse NO-regulated processes, including seed germination, stomatal closure, and hypocotyl elongation. Furthermore, we define the molecular mechanism for NO control of germination and crosstalk with abscisic acid (ABA) signaling through ERF-regulated expression of ABSCISIC ACID INSENSITIVE5 (ABI5). Our work demonstrates how NO sensing is integrated across multiple physiological processes by direct modulation of transcription factor stability and identifies group VII ERFs as central hubs for the perception of gaseous signals in plants. Elsevier 2014-02-06 Article PeerReviewed Gibbs, Daniel J., Md Isa, Nurulhikma, Movahedi, Mahsa, Lozano-Juste, Jorge, Mendiondo, Guillermina M., Berckhan, Sophie, Marín-de la Rosa, Nora, Vicente Conde, Jorge, Sousa Correia, Cristina, Pearce, Simon P., Bassel, George W., Hamali, Bulut, Talloji, Prabhavathi, Tomé, Daniel F.A., Coego, Alberto, Beynon, Jim, Alabadí, David, Bachmair, Andreas, León, José, Gray, Julie E., Theodoulou, Frederica L. and Holdsworth, Michael J. (2014) Nitric oxide sensing in plants is mediated by proteolytic control of Group VII ERF transcription factors. Molecular Cell, 53 (3). pp. 369-379. ISSN 1097-4164 http://www.sciencedirect.com/science/article/pii/S1097276513009301 doi:10.1016/j.molcel.2013.12.020 doi:10.1016/j.molcel.2013.12.020 |
| spellingShingle | Gibbs, Daniel J. Md Isa, Nurulhikma Movahedi, Mahsa Lozano-Juste, Jorge Mendiondo, Guillermina M. Berckhan, Sophie Marín-de la Rosa, Nora Vicente Conde, Jorge Sousa Correia, Cristina Pearce, Simon P. Bassel, George W. Hamali, Bulut Talloji, Prabhavathi Tomé, Daniel F.A. Coego, Alberto Beynon, Jim Alabadí, David Bachmair, Andreas León, José Gray, Julie E. Theodoulou, Frederica L. Holdsworth, Michael J. Nitric oxide sensing in plants is mediated by proteolytic control of Group VII ERF transcription factors |
| title | Nitric oxide sensing in plants is mediated by proteolytic control of Group VII ERF transcription factors |
| title_full | Nitric oxide sensing in plants is mediated by proteolytic control of Group VII ERF transcription factors |
| title_fullStr | Nitric oxide sensing in plants is mediated by proteolytic control of Group VII ERF transcription factors |
| title_full_unstemmed | Nitric oxide sensing in plants is mediated by proteolytic control of Group VII ERF transcription factors |
| title_short | Nitric oxide sensing in plants is mediated by proteolytic control of Group VII ERF transcription factors |
| title_sort | nitric oxide sensing in plants is mediated by proteolytic control of group vii erf transcription factors |
| url | https://eprints.nottingham.ac.uk/40042/ https://eprints.nottingham.ac.uk/40042/ https://eprints.nottingham.ac.uk/40042/ |