PAMFix, a fixative developed to enable remote platelet function testing: uses and applications
PAMFix is a fixative that was developed to stabilise the platelet biomarker P-selectin on activated platelets. Stabilisation of this biomarker introduced the possibility of performing measurements of platelet function remotelywhere there was no access to special equipment or technical expertise. The...
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| Format: | Article |
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Research Trends
2015
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| Online Access: | https://eprints.nottingham.ac.uk/40035/ |
| _version_ | 1848795972636770304 |
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| author | Heptinstall, Stan Fox, Susan May, Jane White, Ann Dovlatova, Natalia |
| author_facet | Heptinstall, Stan Fox, Susan May, Jane White, Ann Dovlatova, Natalia |
| author_sort | Heptinstall, Stan |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | PAMFix is a fixative that was developed to stabilise the platelet biomarker P-selectin on activated platelets. Stabilisation of this biomarker introduced the possibility of performing measurements of platelet function remotelywhere there was no access to special equipment or technical expertise. The idea was to use PAMFix to fix the platelets after stimulating platelets in blood, after which the stabilised samples would be transported to a central laboratory for ana`lysis by flow cytometry. This would obviate the need for special equipment or technical expertise at or near the point at which the blood was collected and processed. Here we demonstrate the stability of samples of blood treated with PAMFix and describe several applications which the use of PAMFix has proved to be particularly beneficial. |
| first_indexed | 2025-11-14T19:40:35Z |
| format | Article |
| id | nottingham-40035 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:40:35Z |
| publishDate | 2015 |
| publisher | Research Trends |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-400352020-05-04T16:58:01Z https://eprints.nottingham.ac.uk/40035/ PAMFix, a fixative developed to enable remote platelet function testing: uses and applications Heptinstall, Stan Fox, Susan May, Jane White, Ann Dovlatova, Natalia PAMFix is a fixative that was developed to stabilise the platelet biomarker P-selectin on activated platelets. Stabilisation of this biomarker introduced the possibility of performing measurements of platelet function remotelywhere there was no access to special equipment or technical expertise. The idea was to use PAMFix to fix the platelets after stimulating platelets in blood, after which the stabilised samples would be transported to a central laboratory for ana`lysis by flow cytometry. This would obviate the need for special equipment or technical expertise at or near the point at which the blood was collected and processed. Here we demonstrate the stability of samples of blood treated with PAMFix and describe several applications which the use of PAMFix has proved to be particularly beneficial. Research Trends 2015-01-01 Article PeerReviewed Heptinstall, Stan, Fox, Susan, May, Jane, White, Ann and Dovlatova, Natalia (2015) PAMFix, a fixative developed to enable remote platelet function testing: uses and applications. Current Topics in Pharmacology, 19 . pp. 1-12. ISSN 0972-4559 PAMFix P-selectin fixing solutions remote platelet function testing aspirin clopidogrel. P2Y12 antagonists |
| spellingShingle | PAMFix P-selectin fixing solutions remote platelet function testing aspirin clopidogrel. P2Y12 antagonists Heptinstall, Stan Fox, Susan May, Jane White, Ann Dovlatova, Natalia PAMFix, a fixative developed to enable remote platelet function testing: uses and applications |
| title | PAMFix, a fixative developed to enable remote platelet function testing: uses and applications |
| title_full | PAMFix, a fixative developed to enable remote platelet function testing: uses and applications |
| title_fullStr | PAMFix, a fixative developed to enable remote platelet function testing: uses and applications |
| title_full_unstemmed | PAMFix, a fixative developed to enable remote platelet function testing: uses and applications |
| title_short | PAMFix, a fixative developed to enable remote platelet function testing: uses and applications |
| title_sort | pamfix, a fixative developed to enable remote platelet function testing: uses and applications |
| topic | PAMFix P-selectin fixing solutions remote platelet function testing aspirin clopidogrel. P2Y12 antagonists |
| url | https://eprints.nottingham.ac.uk/40035/ |