Recent progress in translational research on neurovascular and neurodegenerative disorders
The already established and widely used intravenous application of recombinant tissue plasminogen activator as a re-opening strategy for acute vessel occlusion in ischemic stroke was recently added by mechanical thrombectomy, representing a fundamental progress in evidence-based medicine to improve...
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| Format: | Article |
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IOS Press
2017
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| Online Access: | https://eprints.nottingham.ac.uk/40021/ |
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| author | Demuth, Hans-Ulrich Dijkhuizen, Rick M. Farr, Tracy D. Gelderblom, Mathias Horsburgh, Karen Iadecola, Constantino Mcleod, Damian D. Michalski, Dominik Murphy, Tim H. Orbe, Josuna Otte, Willem M. Petzold, Gabor C. Plesnila, Nikolaus Reiser, Georg Reymann, Klaus G. Rueger, Maria A. Saur, Dorothee Savitz, Sean I. Schilling, Stephan Spratt, Neil J. Turner, Renée J. Vemuganti, Raghu Vivien, Denis Yepes, Manuel Zille, Marietta Boltze, Johannes |
| author_facet | Demuth, Hans-Ulrich Dijkhuizen, Rick M. Farr, Tracy D. Gelderblom, Mathias Horsburgh, Karen Iadecola, Constantino Mcleod, Damian D. Michalski, Dominik Murphy, Tim H. Orbe, Josuna Otte, Willem M. Petzold, Gabor C. Plesnila, Nikolaus Reiser, Georg Reymann, Klaus G. Rueger, Maria A. Saur, Dorothee Savitz, Sean I. Schilling, Stephan Spratt, Neil J. Turner, Renée J. Vemuganti, Raghu Vivien, Denis Yepes, Manuel Zille, Marietta Boltze, Johannes |
| author_sort | Demuth, Hans-Ulrich |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The already established and widely used intravenous application of recombinant tissue plasminogen activator as a re-opening strategy for acute vessel occlusion in ischemic stroke was recently added by mechanical thrombectomy, representing a fundamental progress in evidence-based medicine to improve the patient’s outcome. This has been paralleled by a swift increase in our understanding of pathomechanisms underlying many neurovascular diseases and most prevalent forms of dementia. Taken together, these current advances offer the potential to overcome almost two decades of marginally successful translational research on stroke and dementia, thereby spurring the entire field of translational neuroscience. Moreover, they may also pave the way for the renaissance of classical neuroprotective paradigms.
This review reports and summarizes some of the most interesting and promising recent achievements in neurovascular and dementia research. It highlights sessions from the 9th International Symposium on Neuroprotection and Neurorepair that have been discussed from April 19th to 22nd in Leipzig, Germany. To acknowledge the emerging culture of interdisciplinary collaboration and research, special emphasis is given on translational stories ranging from fundamental research on neurode- and -regeneration to late stage translational or early stage clinical investigations. |
| first_indexed | 2025-11-14T19:40:31Z |
| format | Article |
| id | nottingham-40021 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:40:31Z |
| publishDate | 2017 |
| publisher | IOS Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-400212020-05-04T18:28:53Z https://eprints.nottingham.ac.uk/40021/ Recent progress in translational research on neurovascular and neurodegenerative disorders Demuth, Hans-Ulrich Dijkhuizen, Rick M. Farr, Tracy D. Gelderblom, Mathias Horsburgh, Karen Iadecola, Constantino Mcleod, Damian D. Michalski, Dominik Murphy, Tim H. Orbe, Josuna Otte, Willem M. Petzold, Gabor C. Plesnila, Nikolaus Reiser, Georg Reymann, Klaus G. Rueger, Maria A. Saur, Dorothee Savitz, Sean I. Schilling, Stephan Spratt, Neil J. Turner, Renée J. Vemuganti, Raghu Vivien, Denis Yepes, Manuel Zille, Marietta Boltze, Johannes The already established and widely used intravenous application of recombinant tissue plasminogen activator as a re-opening strategy for acute vessel occlusion in ischemic stroke was recently added by mechanical thrombectomy, representing a fundamental progress in evidence-based medicine to improve the patient’s outcome. This has been paralleled by a swift increase in our understanding of pathomechanisms underlying many neurovascular diseases and most prevalent forms of dementia. Taken together, these current advances offer the potential to overcome almost two decades of marginally successful translational research on stroke and dementia, thereby spurring the entire field of translational neuroscience. Moreover, they may also pave the way for the renaissance of classical neuroprotective paradigms. This review reports and summarizes some of the most interesting and promising recent achievements in neurovascular and dementia research. It highlights sessions from the 9th International Symposium on Neuroprotection and Neurorepair that have been discussed from April 19th to 22nd in Leipzig, Germany. To acknowledge the emerging culture of interdisciplinary collaboration and research, special emphasis is given on translational stories ranging from fundamental research on neurode- and -regeneration to late stage translational or early stage clinical investigations. IOS Press 2017-01-31 Article PeerReviewed Demuth, Hans-Ulrich, Dijkhuizen, Rick M., Farr, Tracy D., Gelderblom, Mathias, Horsburgh, Karen, Iadecola, Constantino, Mcleod, Damian D., Michalski, Dominik, Murphy, Tim H., Orbe, Josuna, Otte, Willem M., Petzold, Gabor C., Plesnila, Nikolaus, Reiser, Georg, Reymann, Klaus G., Rueger, Maria A., Saur, Dorothee, Savitz, Sean I., Schilling, Stephan, Spratt, Neil J., Turner, Renée J., Vemuganti, Raghu, Vivien, Denis, Yepes, Manuel, Zille, Marietta and Boltze, Johannes (2017) Recent progress in translational research on neurovascular and neurodegenerative disorders. Restorative Neurology and Neuroscience, 35 (1). pp. 87-103. ISSN 1878-3627 Alzheimer’s disease brain cerebral ischemia cerebral small vessel disease dementia experimental therapy hemorrhage in vivo imaging neuroimmunology neuroprotection neurorepair sex differences stroke translational research vascular cognitive impairment http://content.iospress.com/articles/restorative-neurology-and-neuroscience/rnn160690 doi:10.3233/RNN-160690 doi:10.3233/RNN-160690 |
| spellingShingle | Alzheimer’s disease brain cerebral ischemia cerebral small vessel disease dementia experimental therapy hemorrhage in vivo imaging neuroimmunology neuroprotection neurorepair sex differences stroke translational research vascular cognitive impairment Demuth, Hans-Ulrich Dijkhuizen, Rick M. Farr, Tracy D. Gelderblom, Mathias Horsburgh, Karen Iadecola, Constantino Mcleod, Damian D. Michalski, Dominik Murphy, Tim H. Orbe, Josuna Otte, Willem M. Petzold, Gabor C. Plesnila, Nikolaus Reiser, Georg Reymann, Klaus G. Rueger, Maria A. Saur, Dorothee Savitz, Sean I. Schilling, Stephan Spratt, Neil J. Turner, Renée J. Vemuganti, Raghu Vivien, Denis Yepes, Manuel Zille, Marietta Boltze, Johannes Recent progress in translational research on neurovascular and neurodegenerative disorders |
| title | Recent progress in translational research on neurovascular and neurodegenerative disorders |
| title_full | Recent progress in translational research on neurovascular and neurodegenerative disorders |
| title_fullStr | Recent progress in translational research on neurovascular and neurodegenerative disorders |
| title_full_unstemmed | Recent progress in translational research on neurovascular and neurodegenerative disorders |
| title_short | Recent progress in translational research on neurovascular and neurodegenerative disorders |
| title_sort | recent progress in translational research on neurovascular and neurodegenerative disorders |
| topic | Alzheimer’s disease brain cerebral ischemia cerebral small vessel disease dementia experimental therapy hemorrhage in vivo imaging neuroimmunology neuroprotection neurorepair sex differences stroke translational research vascular cognitive impairment |
| url | https://eprints.nottingham.ac.uk/40021/ https://eprints.nottingham.ac.uk/40021/ https://eprints.nottingham.ac.uk/40021/ |