Effects of 4 multitargeted receptor tyrosine kinase inhibitors on regional hemodynamics in conscious, freely moving rats

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Effects of 4 multitargeted receptor tyrosine kinase inhibitors on regional hemodynamics in conscious, freely moving rats

VEGF inhibitors, including receptor tyrosine kinase inhibitors, are used as adjunct therapies in a number of cancer treatments. An emerging issue with these drugs is that most cause hypertension. To gain insight into the physiological mechanisms involved, we evaluated their regional hemodynamic effe...

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Bibliographic Details
Main Authors:	Carter, Joanne J., Fretwell, Laurice, Woolard, Jeanette
Format:	Article
Published:	Federation of American Society of Experimental Biology 2016
Subjects:	Cancer therapy Hypertension RTKI VEGF Regional hemodynamics
Online Access:	https://eprints.nottingham.ac.uk/39995/

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