Exploring gastrointestinal variables affecting drug and formulation behavior: methodologies, challenges and opportunities
Various gastrointestinal (GI) factors affect drug and formulation behavior after oral administration, including GI transfer, motility, pH and GI fluid volume and composition. An in-depth understanding of these physiological and anatomical variables is critical for a continued progress in oral drug d...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
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Elsevier
2017
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| Online Access: | https://eprints.nottingham.ac.uk/39960/ |
| _version_ | 1848795954468093952 |
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| author | Hens, Bart Corsetti, Maura Spiller, Robin C. Marciani, Luca Vanuytsel, Tim Tack, Jan Talattof, Arjang Amidon, Gordon L. Koziolek, Mirko Weitschies, Werner Wilson, Clive G. Bennink, Roelof J. Brouwers, Joachim Augustijns, Patrick |
| author_facet | Hens, Bart Corsetti, Maura Spiller, Robin C. Marciani, Luca Vanuytsel, Tim Tack, Jan Talattof, Arjang Amidon, Gordon L. Koziolek, Mirko Weitschies, Werner Wilson, Clive G. Bennink, Roelof J. Brouwers, Joachim Augustijns, Patrick |
| author_sort | Hens, Bart |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Various gastrointestinal (GI) factors affect drug and formulation behavior after oral administration, including GI transfer, motility, pH and GI fluid volume and composition. An in-depth understanding of these physiological and anatomical variables is critical for a continued progress in oral drug development. In this review, different methodologies (invasive versus non-invasive) to explore the impact of physiological variables on formulation behavior in the human GI tract are presented, revealing their strengths and limitations. The techniques mentioned allow for an improved understanding of the role of following GI variables: gastric emptying (magnetic resonance imaging (MRI), scintigraphy, acetaminophen absorption technique, ultrasonography, breath test, intraluminal sampling and telemetry), motility (MRI, small intestinal/colonic manometry and telemetry), GI volume changes (MRI and ultrasonography), temperature (telemetry) and intraluminal pH (intraluminal sampling and telemetry). |
| first_indexed | 2025-11-14T19:40:17Z |
| format | Article |
| id | nottingham-39960 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:40:17Z |
| publishDate | 2017 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-399602020-05-04T18:37:44Z https://eprints.nottingham.ac.uk/39960/ Exploring gastrointestinal variables affecting drug and formulation behavior: methodologies, challenges and opportunities Hens, Bart Corsetti, Maura Spiller, Robin C. Marciani, Luca Vanuytsel, Tim Tack, Jan Talattof, Arjang Amidon, Gordon L. Koziolek, Mirko Weitschies, Werner Wilson, Clive G. Bennink, Roelof J. Brouwers, Joachim Augustijns, Patrick Various gastrointestinal (GI) factors affect drug and formulation behavior after oral administration, including GI transfer, motility, pH and GI fluid volume and composition. An in-depth understanding of these physiological and anatomical variables is critical for a continued progress in oral drug development. In this review, different methodologies (invasive versus non-invasive) to explore the impact of physiological variables on formulation behavior in the human GI tract are presented, revealing their strengths and limitations. The techniques mentioned allow for an improved understanding of the role of following GI variables: gastric emptying (magnetic resonance imaging (MRI), scintigraphy, acetaminophen absorption technique, ultrasonography, breath test, intraluminal sampling and telemetry), motility (MRI, small intestinal/colonic manometry and telemetry), GI volume changes (MRI and ultrasonography), temperature (telemetry) and intraluminal pH (intraluminal sampling and telemetry). Elsevier 2017-03-15 Article PeerReviewed Hens, Bart, Corsetti, Maura, Spiller, Robin C., Marciani, Luca, Vanuytsel, Tim, Tack, Jan, Talattof, Arjang, Amidon, Gordon L., Koziolek, Mirko, Weitschies, Werner, Wilson, Clive G., Bennink, Roelof J., Brouwers, Joachim and Augustijns, Patrick (2017) Exploring gastrointestinal variables affecting drug and formulation behavior: methodologies, challenges and opportunities. International Journal of Pharmaceutics, 519 (1-2). pp. 79-97. ISSN 1873-3476 Intestinal absorption MRI Scintigraphy Manometry Telemetry Intraluminal profiling http://www.sciencedirect.com/science/article/pii/S0378517316311267 doi:10.1016/j.ijpharm.2016.11.063 doi:10.1016/j.ijpharm.2016.11.063 |
| spellingShingle | Intestinal absorption MRI Scintigraphy Manometry Telemetry Intraluminal profiling Hens, Bart Corsetti, Maura Spiller, Robin C. Marciani, Luca Vanuytsel, Tim Tack, Jan Talattof, Arjang Amidon, Gordon L. Koziolek, Mirko Weitschies, Werner Wilson, Clive G. Bennink, Roelof J. Brouwers, Joachim Augustijns, Patrick Exploring gastrointestinal variables affecting drug and formulation behavior: methodologies, challenges and opportunities |
| title | Exploring gastrointestinal variables affecting drug and formulation behavior: methodologies, challenges and opportunities |
| title_full | Exploring gastrointestinal variables affecting drug and formulation behavior: methodologies, challenges and opportunities |
| title_fullStr | Exploring gastrointestinal variables affecting drug and formulation behavior: methodologies, challenges and opportunities |
| title_full_unstemmed | Exploring gastrointestinal variables affecting drug and formulation behavior: methodologies, challenges and opportunities |
| title_short | Exploring gastrointestinal variables affecting drug and formulation behavior: methodologies, challenges and opportunities |
| title_sort | exploring gastrointestinal variables affecting drug and formulation behavior: methodologies, challenges and opportunities |
| topic | Intestinal absorption MRI Scintigraphy Manometry Telemetry Intraluminal profiling |
| url | https://eprints.nottingham.ac.uk/39960/ https://eprints.nottingham.ac.uk/39960/ https://eprints.nottingham.ac.uk/39960/ |