Making silicone rubber highly resistant to bacterial attachment using thiol-ene grafting
Biomedical devices are indispensable in modern medicine yet offer surfaces that promote bacterial attachment and biofilm formation, resulting in acute and chronic healthcare-associated infections. We have developed a simple method to graft acrylates to silicone rubber, polydimethylsiloxane (PDMS), a...
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| Format: | Article |
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American Chemical Society
2016
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| Online Access: | https://eprints.nottingham.ac.uk/39951/ |
| _version_ | 1848795952051126272 |
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| author | Magennis, Eugene Peter Hook, Andrew L. Williams, Paul Alexander, Morgan R. |
| author_facet | Magennis, Eugene Peter Hook, Andrew L. Williams, Paul Alexander, Morgan R. |
| author_sort | Magennis, Eugene Peter |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Biomedical devices are indispensable in modern medicine yet offer surfaces that promote bacterial attachment and biofilm formation, resulting in acute and chronic healthcare-associated infections. We have developed a simple method to graft acrylates to silicone rubber, polydimethylsiloxane (PDMS), a commonly used device material that is often colonized by bacteria. We demonstrate a novel method whereby nontoxic bacteria attachment-resistant polymers can be readily grafted from and grafted to the surface using thiol-ene chemistry, substantially reducing bacterial colonization. With use of this approach, bacterial biofilm coverage can be reduced by 99% compared with standard PDMS in an in vitro assay. This grafting approach offers significant advantages over commonly used physisorbed coatings, especially in areas of high shear or mechanical stress. Furthermore, the approach is versatile such that the grafted material properties can be tailored for the desired final application. |
| first_indexed | 2025-11-14T19:40:15Z |
| format | Article |
| id | nottingham-39951 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:40:15Z |
| publishDate | 2016 |
| publisher | American Chemical Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-399512020-05-04T18:15:56Z https://eprints.nottingham.ac.uk/39951/ Making silicone rubber highly resistant to bacterial attachment using thiol-ene grafting Magennis, Eugene Peter Hook, Andrew L. Williams, Paul Alexander, Morgan R. Biomedical devices are indispensable in modern medicine yet offer surfaces that promote bacterial attachment and biofilm formation, resulting in acute and chronic healthcare-associated infections. We have developed a simple method to graft acrylates to silicone rubber, polydimethylsiloxane (PDMS), a commonly used device material that is often colonized by bacteria. We demonstrate a novel method whereby nontoxic bacteria attachment-resistant polymers can be readily grafted from and grafted to the surface using thiol-ene chemistry, substantially reducing bacterial colonization. With use of this approach, bacterial biofilm coverage can be reduced by 99% compared with standard PDMS in an in vitro assay. This grafting approach offers significant advantages over commonly used physisorbed coatings, especially in areas of high shear or mechanical stress. Furthermore, the approach is versatile such that the grafted material properties can be tailored for the desired final application. American Chemical Society 2016-10-24 Article PeerReviewed Magennis, Eugene Peter, Hook, Andrew L., Williams, Paul and Alexander, Morgan R. (2016) Making silicone rubber highly resistant to bacterial attachment using thiol-ene grafting. ACS Applied Materials and Interfaces, 8 (45). pp. 30780-30787. ISSN 1944-8252 Biomaterials PDMS silicone bacteria polymers Pseudomonas catheter http://pubs.acs.org/doi/abs/10.1021/acsami.6b10986 doi:10.1021/acsami.6b10986 doi:10.1021/acsami.6b10986 |
| spellingShingle | Biomaterials PDMS silicone bacteria polymers Pseudomonas catheter Magennis, Eugene Peter Hook, Andrew L. Williams, Paul Alexander, Morgan R. Making silicone rubber highly resistant to bacterial attachment using thiol-ene grafting |
| title | Making silicone rubber highly resistant to bacterial attachment using thiol-ene grafting |
| title_full | Making silicone rubber highly resistant to bacterial attachment using thiol-ene grafting |
| title_fullStr | Making silicone rubber highly resistant to bacterial attachment using thiol-ene grafting |
| title_full_unstemmed | Making silicone rubber highly resistant to bacterial attachment using thiol-ene grafting |
| title_short | Making silicone rubber highly resistant to bacterial attachment using thiol-ene grafting |
| title_sort | making silicone rubber highly resistant to bacterial attachment using thiol-ene grafting |
| topic | Biomaterials PDMS silicone bacteria polymers Pseudomonas catheter |
| url | https://eprints.nottingham.ac.uk/39951/ https://eprints.nottingham.ac.uk/39951/ https://eprints.nottingham.ac.uk/39951/ |