Hemodynamic effects of lung recruitment maneuvers in acute respiratory distress syndrome
Background: Clinical trials have, so far, failed to establish clear beneficial outcomes of recruitment maneuvers (RMs) on patient mortality in acute respiratory distress syndrome (ARDS), and the effects of RMs on the cardiovascular system remain poorly understood. Methods: A computational model wit...
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BioMed Central
2017
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| Online Access: | https://eprints.nottingham.ac.uk/39919/ |
| _version_ | 1848795945815244800 |
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| author | Das, Anup Haque, Mainul Chikhani, Marc Cole, Oana Wang, Wenfei Hardman, Jonathan G. Bates, Declan G. |
| author_facet | Das, Anup Haque, Mainul Chikhani, Marc Cole, Oana Wang, Wenfei Hardman, Jonathan G. Bates, Declan G. |
| author_sort | Das, Anup |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Background: Clinical trials have, so far, failed to establish clear beneficial outcomes of recruitment maneuvers (RMs) on patient mortality in acute respiratory distress syndrome (ARDS), and the effects of RMs on the cardiovascular system remain poorly understood.
Methods: A computational model with highly integrated pulmonary and cardiovascular systems was configured to replicate static and dynamic cardio-pulmonary data from clinical trials. Recruitment maneuvers (RMs) were executed in 23 individual in-silico patients with varying levels of ARDS severity and initial cardiac output. Multiple clinical variables were recorded and analyzed, including arterial oxygenation, cardiac output, peripheral oxygen delivery and alveolar strain.
Results: The maximal recruitment strategy (MRS) maneuver, which implements gradual increments of positive end expiratory pressure (PEEP) followed by PEEP titration, produced improvements in PF ratio, carbon dioxide elimination and dynamic strain in all 23 in-silico patients considered. Reduced cardiac output in the moderate and mild in silico ARDS patients produced significant drops in oxygen delivery during the RM (average decrease of 423 ml min-1 and 526 ml min-1, respectively). In the in-silico patients with severe ARDS, however, significantly improved gas-exchange led to an average increase of 89 ml min-1 in oxygen delivery during the RM, despite a simultaneous fall in cardiac output of more than 3 l min-1 on average. Post RM increases in oxygen delivery were observed only for the in silico patients with severe ARDS. In patients with high baseline cardiac outputs (>6.5 l min-1), oxygen delivery never fell below 700 ml min-1.
Conclusions: Our results support the hypothesis that patients with severe ARDS and significant numbers of alveolar units available for recruitment may benefit more from RMs. Our results also indicate that a higher than normal initial cardiac output may provide protection against the potentially negative effects of high intrathoracic pressures associated with RMs on cardiac function. Results from in silico patients with mild or moderate ARDS suggest that the detrimental effects of RMs on cardiac output can potentially outweigh the positive effects of alveolar recruitment on oxygenation, resulting in overall reductions in tissue oxygen delivery. |
| first_indexed | 2025-11-14T19:40:09Z |
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| id | nottingham-39919 |
| institution | University of Nottingham Malaysia Campus |
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| last_indexed | 2025-11-14T19:40:09Z |
| publishDate | 2017 |
| publisher | BioMed Central |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-399192020-05-04T18:35:30Z https://eprints.nottingham.ac.uk/39919/ Hemodynamic effects of lung recruitment maneuvers in acute respiratory distress syndrome Das, Anup Haque, Mainul Chikhani, Marc Cole, Oana Wang, Wenfei Hardman, Jonathan G. Bates, Declan G. Background: Clinical trials have, so far, failed to establish clear beneficial outcomes of recruitment maneuvers (RMs) on patient mortality in acute respiratory distress syndrome (ARDS), and the effects of RMs on the cardiovascular system remain poorly understood. Methods: A computational model with highly integrated pulmonary and cardiovascular systems was configured to replicate static and dynamic cardio-pulmonary data from clinical trials. Recruitment maneuvers (RMs) were executed in 23 individual in-silico patients with varying levels of ARDS severity and initial cardiac output. Multiple clinical variables were recorded and analyzed, including arterial oxygenation, cardiac output, peripheral oxygen delivery and alveolar strain. Results: The maximal recruitment strategy (MRS) maneuver, which implements gradual increments of positive end expiratory pressure (PEEP) followed by PEEP titration, produced improvements in PF ratio, carbon dioxide elimination and dynamic strain in all 23 in-silico patients considered. Reduced cardiac output in the moderate and mild in silico ARDS patients produced significant drops in oxygen delivery during the RM (average decrease of 423 ml min-1 and 526 ml min-1, respectively). In the in-silico patients with severe ARDS, however, significantly improved gas-exchange led to an average increase of 89 ml min-1 in oxygen delivery during the RM, despite a simultaneous fall in cardiac output of more than 3 l min-1 on average. Post RM increases in oxygen delivery were observed only for the in silico patients with severe ARDS. In patients with high baseline cardiac outputs (>6.5 l min-1), oxygen delivery never fell below 700 ml min-1. Conclusions: Our results support the hypothesis that patients with severe ARDS and significant numbers of alveolar units available for recruitment may benefit more from RMs. Our results also indicate that a higher than normal initial cardiac output may provide protection against the potentially negative effects of high intrathoracic pressures associated with RMs on cardiac function. Results from in silico patients with mild or moderate ARDS suggest that the detrimental effects of RMs on cardiac output can potentially outweigh the positive effects of alveolar recruitment on oxygenation, resulting in overall reductions in tissue oxygen delivery. BioMed Central 2017-02-08 Article PeerReviewed Das, Anup, Haque, Mainul, Chikhani, Marc, Cole, Oana, Wang, Wenfei, Hardman, Jonathan G. and Bates, Declan G. (2017) Hemodynamic effects of lung recruitment maneuvers in acute respiratory distress syndrome. BMC Pulmonary Medicine, 17 (34). pp. 1-13. ISSN 1471-2466 acute respiratory distress syndrome recruitment maneuvers positive end expiratory pressure cardiac output computational modelling oxygen delivery carbon dioxide clearance strain mechanical ventilation https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890-017-0369-7 doi:10.1186/s12890-017-0369-7 doi:10.1186/s12890-017-0369-7 |
| spellingShingle | acute respiratory distress syndrome recruitment maneuvers positive end expiratory pressure cardiac output computational modelling oxygen delivery carbon dioxide clearance strain mechanical ventilation Das, Anup Haque, Mainul Chikhani, Marc Cole, Oana Wang, Wenfei Hardman, Jonathan G. Bates, Declan G. Hemodynamic effects of lung recruitment maneuvers in acute respiratory distress syndrome |
| title | Hemodynamic effects of lung recruitment maneuvers in acute respiratory distress syndrome |
| title_full | Hemodynamic effects of lung recruitment maneuvers in acute respiratory distress syndrome |
| title_fullStr | Hemodynamic effects of lung recruitment maneuvers in acute respiratory distress syndrome |
| title_full_unstemmed | Hemodynamic effects of lung recruitment maneuvers in acute respiratory distress syndrome |
| title_short | Hemodynamic effects of lung recruitment maneuvers in acute respiratory distress syndrome |
| title_sort | hemodynamic effects of lung recruitment maneuvers in acute respiratory distress syndrome |
| topic | acute respiratory distress syndrome recruitment maneuvers positive end expiratory pressure cardiac output computational modelling oxygen delivery carbon dioxide clearance strain mechanical ventilation |
| url | https://eprints.nottingham.ac.uk/39919/ https://eprints.nottingham.ac.uk/39919/ https://eprints.nottingham.ac.uk/39919/ |