Hyperlipidaemia alone and in combination with acidosis can increase the incidence and severity of statin-induced myotoxicity

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Hyperlipidaemia alone and in combination with acidosis can increase the incidence and severity of statin-induced myotoxicity

The association of lipophilic statins with plasma lipoproteins in the presence of disturbed acid-base balance can modify the pharmacokinetics and tissue distribution of these drugs, resulting in alteration in their efficacy and toxicity profiles. The purpose of this study is to elucidate the role of...

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Bibliographic Details
Main Authors:	Taha, Dhiaa A., Zgair, Atheer, Lee, Jong Bong, de Moor, Cornelia H., Barrett, David A., Bruce, Kimberley D., Sungelo, Mitchell, Eckel, Robert H., Gershkovich, Pavel
Format:	Article
Published:	Elsevier 2017
Subjects:	Acidosis Chylomicrons Hyperlipidemia Lipoproteins Myotoxicity Statins
Online Access:	https://eprints.nottingham.ac.uk/39896/

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