Exploring the reactivity of 2-trichloromethylbenzoxazoles for access to substituted benzoxazoles
The reactivity of 2-trichloromethylbenzoxazoles towards various nucleophiles, under metal free or iron-catalyzed conditions, for the synthesis of substituted benzoxazoles is described. These methods allow for selective substitution at either the 2- or 2’- position of the benzoxazoles using the same...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Published: |
American Chemical Society
2016
|
| Online Access: | https://eprints.nottingham.ac.uk/39891/ |
| _version_ | 1848795939282616320 |
|---|---|
| author | Lester, Roy P. Bham, Travis Bousfield, Thomas W. Lewis, William Camp, Jason E. |
| author_facet | Lester, Roy P. Bham, Travis Bousfield, Thomas W. Lewis, William Camp, Jason E. |
| author_sort | Lester, Roy P. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The reactivity of 2-trichloromethylbenzoxazoles towards various nucleophiles, under metal free or iron-catalyzed conditions, for the synthesis of substituted benzoxazoles is described. These methods allow for selective substitution at either the 2- or 2’- position of the benzoxazoles using the same starting materials / reagents. This approach allows for the controlled synthesis of a variety of key derivatives from a single 2-trichloromethylbenzoxazole starting material. |
| first_indexed | 2025-11-14T19:40:03Z |
| format | Article |
| id | nottingham-39891 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:40:03Z |
| publishDate | 2016 |
| publisher | American Chemical Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-398912020-05-04T18:27:24Z https://eprints.nottingham.ac.uk/39891/ Exploring the reactivity of 2-trichloromethylbenzoxazoles for access to substituted benzoxazoles Lester, Roy P. Bham, Travis Bousfield, Thomas W. Lewis, William Camp, Jason E. The reactivity of 2-trichloromethylbenzoxazoles towards various nucleophiles, under metal free or iron-catalyzed conditions, for the synthesis of substituted benzoxazoles is described. These methods allow for selective substitution at either the 2- or 2’- position of the benzoxazoles using the same starting materials / reagents. This approach allows for the controlled synthesis of a variety of key derivatives from a single 2-trichloromethylbenzoxazole starting material. American Chemical Society 2016-12-06 Article PeerReviewed Lester, Roy P., Bham, Travis, Bousfield, Thomas W., Lewis, William and Camp, Jason E. (2016) Exploring the reactivity of 2-trichloromethylbenzoxazoles for access to substituted benzoxazoles. Journal of Organic Chemistry, 84 (24). pp. 12472-12477. ISSN 1520-6904 http://pubs.acs.org/doi/abs/10.1021/acs.joc.6b02315 doi:10.1021/acs.joc.6b02315 doi:10.1021/acs.joc.6b02315 |
| spellingShingle | Lester, Roy P. Bham, Travis Bousfield, Thomas W. Lewis, William Camp, Jason E. Exploring the reactivity of 2-trichloromethylbenzoxazoles for access to substituted benzoxazoles |
| title | Exploring the reactivity of 2-trichloromethylbenzoxazoles for access to substituted benzoxazoles |
| title_full | Exploring the reactivity of 2-trichloromethylbenzoxazoles for access to substituted benzoxazoles |
| title_fullStr | Exploring the reactivity of 2-trichloromethylbenzoxazoles for access to substituted benzoxazoles |
| title_full_unstemmed | Exploring the reactivity of 2-trichloromethylbenzoxazoles for access to substituted benzoxazoles |
| title_short | Exploring the reactivity of 2-trichloromethylbenzoxazoles for access to substituted benzoxazoles |
| title_sort | exploring the reactivity of 2-trichloromethylbenzoxazoles for access to substituted benzoxazoles |
| url | https://eprints.nottingham.ac.uk/39891/ https://eprints.nottingham.ac.uk/39891/ https://eprints.nottingham.ac.uk/39891/ |