Exploring the reactivity of 2-trichloromethylbenzoxazoles for access to substituted benzoxazoles
The reactivity of 2-trichloromethylbenzoxazoles towards various nucleophiles, under metal free or iron-catalyzed conditions, for the synthesis of substituted benzoxazoles is described. These methods allow for selective substitution at either the 2- or 2’- position of the benzoxazoles using the same...
| Main Authors: | , , , , |
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| Format: | Article |
| Published: |
American Chemical Society
2016
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| Online Access: | https://eprints.nottingham.ac.uk/39891/ |
| Summary: | The reactivity of 2-trichloromethylbenzoxazoles towards various nucleophiles, under metal free or iron-catalyzed conditions, for the synthesis of substituted benzoxazoles is described. These methods allow for selective substitution at either the 2- or 2’- position of the benzoxazoles using the same starting materials / reagents. This approach allows for the controlled synthesis of a variety of key derivatives from a single 2-trichloromethylbenzoxazole starting material. |
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