Increased homocysteine levels impair reference memory and reducecortical levels of acetylcholine in a mouse model of vascular cognitive impairment

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Increased homocysteine levels impair reference memory and reducecortical levels of acetylcholine in a mouse model of vascular cognitive impairment

Folates are B-vitamins that are vital for normal brain function. Deficiencies in folates either genetic(methylenetetrahydrofolate reductase, MTHFR) or dietary intake of folic acid result in elevated levelsof homocysteine. Clinical studies have shown that elevated levels of homocysteine (Hcy) may be...

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Bibliographic Details
Main Authors:	Dam, Kevin, Füchtemeier, Martina, Farr, Tracy D., Boehm-Sturm, Philipp, Foddis, Marco, Dirnagl, Ulrich, Malysheva, Olga, Jadavji, Nafisa M.
Format:	Article
Published:	Elsevier 2017
Subjects:	Vascular cognitive impairment; Chronic hypoperfusion; Methylenetetrahydrofolate reductase; Folic acid; Homocysteine; Acetylcholine
Online Access:	https://eprints.nottingham.ac.uk/39876/

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