Terminal sterilization: conventional methods versus emerging cold atmospheric pressure plasma technology for non-viable biological tissues
Tissue products are susceptible to microbial contamination from different sources, which may cause disease transmission upon transplantation. Terminal sterilization using gamma radiation, electron-beam, and ethylene oxide protocols are well-established and accepted, however, such methods have known...
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| Format: | Article |
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Wiley-VCH Verlag
2016
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| Online Access: | https://eprints.nottingham.ac.uk/39871/ |
| _version_ | 1848795933446242304 |
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| author | Marsit, Nagi M. Sidney, Laura E. Branch, Matthew James Wilson, Samantha L. Hopkinson, Andrew |
| author_facet | Marsit, Nagi M. Sidney, Laura E. Branch, Matthew James Wilson, Samantha L. Hopkinson, Andrew |
| author_sort | Marsit, Nagi M. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Tissue products are susceptible to microbial contamination from different sources, which may cause disease transmission upon transplantation. Terminal sterilization using gamma radiation, electron-beam, and ethylene oxide protocols are well-established and accepted, however, such methods have known disadvantages associated with compromised tissue integrity, functionality, safety, complex logistics, availability, and cost. Non-thermal (cold) atmospheric pressure plasma (CAP) is an emerging technology that has several biomedical applications including sterilization of tissues, and the potential to surpass current terminal sterilization techniques. This review discusses the limitations of conventional terminal sterilization technologies for biological materials, and highlights the benefits of utilizing CAP. |
| first_indexed | 2025-11-14T19:39:57Z |
| format | Article |
| id | nottingham-39871 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:39:57Z |
| publishDate | 2016 |
| publisher | Wiley-VCH Verlag |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-398712020-05-04T18:25:48Z https://eprints.nottingham.ac.uk/39871/ Terminal sterilization: conventional methods versus emerging cold atmospheric pressure plasma technology for non-viable biological tissues Marsit, Nagi M. Sidney, Laura E. Branch, Matthew James Wilson, Samantha L. Hopkinson, Andrew Tissue products are susceptible to microbial contamination from different sources, which may cause disease transmission upon transplantation. Terminal sterilization using gamma radiation, electron-beam, and ethylene oxide protocols are well-established and accepted, however, such methods have known disadvantages associated with compromised tissue integrity, functionality, safety, complex logistics, availability, and cost. Non-thermal (cold) atmospheric pressure plasma (CAP) is an emerging technology that has several biomedical applications including sterilization of tissues, and the potential to surpass current terminal sterilization techniques. This review discusses the limitations of conventional terminal sterilization technologies for biological materials, and highlights the benefits of utilizing CAP. Wiley-VCH Verlag 2016-12-15 Article PeerReviewed Marsit, Nagi M., Sidney, Laura E., Branch, Matthew James, Wilson, Samantha L. and Hopkinson, Andrew (2016) Terminal sterilization: conventional methods versus emerging cold atmospheric pressure plasma technology for non-viable biological tissues. Plasma Processes and Polymers . p. 201600134. ISSN 1612-8869 Cold plasma; Dielectric barrier discharge; Plasma treatment; Sterilization; Tissue engineering http://onlinelibrary.wiley.com/doi/10.1002/ppap.201600134/abstract doi:10.1002/ppap.201600134 doi:10.1002/ppap.201600134 |
| spellingShingle | Cold plasma; Dielectric barrier discharge; Plasma treatment; Sterilization; Tissue engineering Marsit, Nagi M. Sidney, Laura E. Branch, Matthew James Wilson, Samantha L. Hopkinson, Andrew Terminal sterilization: conventional methods versus emerging cold atmospheric pressure plasma technology for non-viable biological tissues |
| title | Terminal sterilization: conventional methods versus emerging cold atmospheric pressure plasma technology for non-viable biological tissues |
| title_full | Terminal sterilization: conventional methods versus emerging cold atmospheric pressure plasma technology for non-viable biological tissues |
| title_fullStr | Terminal sterilization: conventional methods versus emerging cold atmospheric pressure plasma technology for non-viable biological tissues |
| title_full_unstemmed | Terminal sterilization: conventional methods versus emerging cold atmospheric pressure plasma technology for non-viable biological tissues |
| title_short | Terminal sterilization: conventional methods versus emerging cold atmospheric pressure plasma technology for non-viable biological tissues |
| title_sort | terminal sterilization: conventional methods versus emerging cold atmospheric pressure plasma technology for non-viable biological tissues |
| topic | Cold plasma; Dielectric barrier discharge; Plasma treatment; Sterilization; Tissue engineering |
| url | https://eprints.nottingham.ac.uk/39871/ https://eprints.nottingham.ac.uk/39871/ https://eprints.nottingham.ac.uk/39871/ |