Medulloblastoma and ependymoma cells display levels of 5-carboxylcytosine and elevated TET1 expression

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Medulloblastoma and ependymoma cells display levels of 5-carboxylcytosine and elevated TET1 expression

Background Alteration of DNA methylation (5-methylcytosine, 5mC) patterns represents one of the causes of tumorigenesis and cancer progression. Tet proteins can oxidize 5mC to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine and 5-carboxylcytosine (5caC). Although the roles of these oxidised forms...

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Bibliographic Details
Main Authors:	Ramsawhook, Ashley, Lewis, Lara, Coyle, Beth, Ruzov, Alexey
Format:	Article
Published:	BioMed Central 2017
Subjects:	DNA methylation; 5-hydroxymethylcytosine; 5-carboxylcytosine; Paediatric brain tumours; Medulloblastoma; Ependymoma; Immunohistochemistry
Online Access:	https://eprints.nottingham.ac.uk/39834/

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