Physical and biological characteristics of multi drug resistance (MDR): an integral approach considering pH and drug resistance in cancer
The role of the Warburg effect in cancer remains to be elucidated with a resurgence in research efforts over the past decade. Why a cancer cell would prefer to use energy inefficient glycolysis, leading to an alteration of pH both inside and outside of the cell, remains to be uncovered. The developm...
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| Format: | Article |
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Elsevier
2017
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| Online Access: | https://eprints.nottingham.ac.uk/39780/ |
| _version_ | 1848795912561754112 |
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| author | Omran, Ziad Scaife, Paula Stewart, Simon Rauch, Cyril |
| author_facet | Omran, Ziad Scaife, Paula Stewart, Simon Rauch, Cyril |
| author_sort | Omran, Ziad |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The role of the Warburg effect in cancer remains to be elucidated with a resurgence in research efforts over the past decade. Why a cancer cell would prefer to use energy inefficient glycolysis, leading to an alteration of pH both inside and outside of the cell, remains to be uncovered. The development of MDR represents a major challenge in the treatment of cancer and it is explained, so far, by the over expression of drug transporters such as the well-known and archetypal P-glycoprotein (Pgp). However, controversies exist regarding the function of Pgp in multi-drug resistance. We suggest here that Pgp-mediated MDR relies fundamentally on pH alterations mediated by the Warburg effect. Furthermore, we propose that the use of proton pump and/or transporters inhibitors (PPIs/PTIs) in cancer are key to controlling both MDR, i.e. sensitize tumors to antineoplastic agents, and drug-related adverse effects. |
| first_indexed | 2025-11-14T19:39:38Z |
| format | Article |
| id | nottingham-39780 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:39:38Z |
| publishDate | 2017 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-397802020-05-04T19:58:10Z https://eprints.nottingham.ac.uk/39780/ Physical and biological characteristics of multi drug resistance (MDR): an integral approach considering pH and drug resistance in cancer Omran, Ziad Scaife, Paula Stewart, Simon Rauch, Cyril The role of the Warburg effect in cancer remains to be elucidated with a resurgence in research efforts over the past decade. Why a cancer cell would prefer to use energy inefficient glycolysis, leading to an alteration of pH both inside and outside of the cell, remains to be uncovered. The development of MDR represents a major challenge in the treatment of cancer and it is explained, so far, by the over expression of drug transporters such as the well-known and archetypal P-glycoprotein (Pgp). However, controversies exist regarding the function of Pgp in multi-drug resistance. We suggest here that Pgp-mediated MDR relies fundamentally on pH alterations mediated by the Warburg effect. Furthermore, we propose that the use of proton pump and/or transporters inhibitors (PPIs/PTIs) in cancer are key to controlling both MDR, i.e. sensitize tumors to antineoplastic agents, and drug-related adverse effects. Elsevier 2017-04 Article PeerReviewed Omran, Ziad, Scaife, Paula, Stewart, Simon and Rauch, Cyril (2017) Physical and biological characteristics of multi drug resistance (MDR): an integral approach considering pH and drug resistance in cancer. Seminars in Cancer Biology, 43 . pp. 42-48. ISSN 1096-3650 Pharmacokinetic; Drug transporter; Membrane biophysics; Warburg effect http://www.sciencedirect.com/science/article/pii/S1044579X17300020 doi:10.1016/j.semcancer.2017.01.002 doi:10.1016/j.semcancer.2017.01.002 |
| spellingShingle | Pharmacokinetic; Drug transporter; Membrane biophysics; Warburg effect Omran, Ziad Scaife, Paula Stewart, Simon Rauch, Cyril Physical and biological characteristics of multi drug resistance (MDR): an integral approach considering pH and drug resistance in cancer |
| title | Physical and biological characteristics of multi drug resistance (MDR): an integral approach considering pH and drug resistance in cancer |
| title_full | Physical and biological characteristics of multi drug resistance (MDR): an integral approach considering pH and drug resistance in cancer |
| title_fullStr | Physical and biological characteristics of multi drug resistance (MDR): an integral approach considering pH and drug resistance in cancer |
| title_full_unstemmed | Physical and biological characteristics of multi drug resistance (MDR): an integral approach considering pH and drug resistance in cancer |
| title_short | Physical and biological characteristics of multi drug resistance (MDR): an integral approach considering pH and drug resistance in cancer |
| title_sort | physical and biological characteristics of multi drug resistance (mdr): an integral approach considering ph and drug resistance in cancer |
| topic | Pharmacokinetic; Drug transporter; Membrane biophysics; Warburg effect |
| url | https://eprints.nottingham.ac.uk/39780/ https://eprints.nottingham.ac.uk/39780/ https://eprints.nottingham.ac.uk/39780/ |