Tumour regression and improved gastrointestinal tolerability from controlled release of SN-38 from novel polyoxazoline-modified dendrimers

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Tumour regression and improved gastrointestinal tolerability from controlled release of SN-38 from novel polyoxazoline-modified dendrimers

Irinotecan is used clinically for the treatment of colorectal cancer; however, its utility is limited by its narrow therapeutic index. We describe the use of a generation 5 l-lysine dendrimer that has been part-modified with a polyoxazoline as a drug delivery vehicle for improving the therapeutic in...

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Bibliographic Details
Main Authors:	England, Richard M., Hare, Jennifer I., Barnes, Jennifer, Wilson, Joanne, Smith, Aaron, Strittmatter, Nicole, Kemmitt, Paul D., Waring, Michael J., Barry, Simon T., Alexander, Cameron, Ashford, Marianne B.
Format:	Article
Published:	Elsevier 2017
Subjects:	Nanomedicine; Irinotecan; SN-38; Dendrimer; Colorectal cancer; Drug delivery; Therapeutic index
Online Access:	https://eprints.nottingham.ac.uk/39758/

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