The incidence, prevalence and mortality of granulomatosis with polyangiitis in the UK Clinical Practice Research Datalink
Objectives: To estimate the incidence, prevalence and mortality of Granulomatosis with polyangiitis (GPA) in the United Kingdom. Methods: We conducted a historical cohort study using data from the Clinical Practice Research Datalink and Hospital Episode Statistics (CPRD-HES). We calculated incidenc...
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| Format: | Article |
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Oxford University Press
2016
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| Online Access: | https://eprints.nottingham.ac.uk/39731/ |
| _version_ | 1848795900396175360 |
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| author | Pearce, Fiona A. Grainge, Matthew J. Lanyon, Peter C. Watts, Richard A Hubbard, Richard B. |
| author_facet | Pearce, Fiona A. Grainge, Matthew J. Lanyon, Peter C. Watts, Richard A Hubbard, Richard B. |
| author_sort | Pearce, Fiona A. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Objectives: To estimate the incidence, prevalence and mortality of Granulomatosis with polyangiitis (GPA) in the United Kingdom.
Methods: We conducted a historical cohort study using data from the Clinical Practice Research Datalink and Hospital Episode Statistics (CPRD-HES). We calculated incidence rate ratios, adjusted for age, gender and ethnicity, using Poisson regression.
Results: We identified 462 cases diagnosed between 1997 and 2013. Our overall estimate of incidence was 11.8 (95% CI 10.7-12.9)/million person-years. Incidence in children (aged <16 years) was 0.88 (95% CI 0.40-1.96), and adults 14.0 (95% CI 12.8-15.4). The incidence was lower in females (adjusted IRR 0.68; 95% CI 0.56-0.81) and highest in the 55-69 year age-group (adjusted IRR 9.5, 95% CI 6.9-13.0; reference group 0-39 years). Incidence was not significantly different in the Black / Minority Ethnic population compared to the white population (adjusted odds ratio 0.78, 95% CI 0.53-1.13, p=0.13). The prevalence in 2013 was 134.9 (121.3-149.6) /million. Mortality was 13.6% at 1-year, and higher in HES than CPRD-identified cases (Hazard ratio 3.16, 95% CI 2.19-4.56, p<0.001).
Conclusions: By combining primary and secondary care datasets we have found the incidence and mortality of granulomatosis with polyangiitis to be higher than previously reported. We predict that at present each year in the UK there will be approximately 700 new cases of whom 95 will die within 12 months. |
| first_indexed | 2025-11-14T19:39:26Z |
| format | Article |
| id | nottingham-39731 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:39:26Z |
| publishDate | 2016 |
| publisher | Oxford University Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-397312024-08-15T15:21:13Z https://eprints.nottingham.ac.uk/39731/ The incidence, prevalence and mortality of granulomatosis with polyangiitis in the UK Clinical Practice Research Datalink Pearce, Fiona A. Grainge, Matthew J. Lanyon, Peter C. Watts, Richard A Hubbard, Richard B. Objectives: To estimate the incidence, prevalence and mortality of Granulomatosis with polyangiitis (GPA) in the United Kingdom. Methods: We conducted a historical cohort study using data from the Clinical Practice Research Datalink and Hospital Episode Statistics (CPRD-HES). We calculated incidence rate ratios, adjusted for age, gender and ethnicity, using Poisson regression. Results: We identified 462 cases diagnosed between 1997 and 2013. Our overall estimate of incidence was 11.8 (95% CI 10.7-12.9)/million person-years. Incidence in children (aged <16 years) was 0.88 (95% CI 0.40-1.96), and adults 14.0 (95% CI 12.8-15.4). The incidence was lower in females (adjusted IRR 0.68; 95% CI 0.56-0.81) and highest in the 55-69 year age-group (adjusted IRR 9.5, 95% CI 6.9-13.0; reference group 0-39 years). Incidence was not significantly different in the Black / Minority Ethnic population compared to the white population (adjusted odds ratio 0.78, 95% CI 0.53-1.13, p=0.13). The prevalence in 2013 was 134.9 (121.3-149.6) /million. Mortality was 13.6% at 1-year, and higher in HES than CPRD-identified cases (Hazard ratio 3.16, 95% CI 2.19-4.56, p<0.001). Conclusions: By combining primary and secondary care datasets we have found the incidence and mortality of granulomatosis with polyangiitis to be higher than previously reported. We predict that at present each year in the UK there will be approximately 700 new cases of whom 95 will die within 12 months. Oxford University Press 2016-12-24 Article PeerReviewed Pearce, Fiona A., Grainge, Matthew J., Lanyon, Peter C., Watts, Richard A and Hubbard, Richard B. (2016) The incidence, prevalence and mortality of granulomatosis with polyangiitis in the UK Clinical Practice Research Datalink. Rheumatology . pp. 1-8. ISSN 1462-0324 vasculitis incidence prevalence mortality epidemiology http://rheumatology.oxfordjournals.org/content/early/2016/12/21/rheumatology.kew413 doi:10.1093/rheumatology/kew413 doi:10.1093/rheumatology/kew413 |
| spellingShingle | vasculitis incidence prevalence mortality epidemiology Pearce, Fiona A. Grainge, Matthew J. Lanyon, Peter C. Watts, Richard A Hubbard, Richard B. The incidence, prevalence and mortality of granulomatosis with polyangiitis in the UK Clinical Practice Research Datalink |
| title | The incidence, prevalence and mortality of granulomatosis with polyangiitis in the UK Clinical Practice Research Datalink |
| title_full | The incidence, prevalence and mortality of granulomatosis with polyangiitis in the UK Clinical Practice Research Datalink |
| title_fullStr | The incidence, prevalence and mortality of granulomatosis with polyangiitis in the UK Clinical Practice Research Datalink |
| title_full_unstemmed | The incidence, prevalence and mortality of granulomatosis with polyangiitis in the UK Clinical Practice Research Datalink |
| title_short | The incidence, prevalence and mortality of granulomatosis with polyangiitis in the UK Clinical Practice Research Datalink |
| title_sort | incidence, prevalence and mortality of granulomatosis with polyangiitis in the uk clinical practice research datalink |
| topic | vasculitis incidence prevalence mortality epidemiology |
| url | https://eprints.nottingham.ac.uk/39731/ https://eprints.nottingham.ac.uk/39731/ https://eprints.nottingham.ac.uk/39731/ |