‘Browning’ the cardiac and peri-vascular adipose tissues to modulate cardiovascular risk
Excess visceral adiposity, in particular that located adjacent to the heart and coronary arteries is associated with increased cardiovascular risk. In the pathophysiological state, dysfunctional adipose tissue secretes an array of factors modulating vascular function and driving atherogenesis. Conve...
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| Format: | Article |
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Elsevier
2017
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| Online Access: | https://eprints.nottingham.ac.uk/39635/ |
| _version_ | 1848795880737472512 |
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| author | Aldiss, Peter Davies, Graeme Woods, Rachel Budge, Helen Sacks, Harold S. Symonds, Michael E. |
| author_facet | Aldiss, Peter Davies, Graeme Woods, Rachel Budge, Helen Sacks, Harold S. Symonds, Michael E. |
| author_sort | Aldiss, Peter |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Excess visceral adiposity, in particular that located adjacent to the heart and coronary arteries is associated with increased cardiovascular risk. In the pathophysiological state, dysfunctional adipose tissue secretes an array of factors modulating vascular function and driving atherogenesis. Conversely, brown and beige adipose tissues utilise glucose and lipids to generate heat and are associated with improved cardiometabolic health. The cardiac and thoracic perivascular adipose tissues are now understood to be composed of brown adipose tissue in the healthy state and undergo a brown-to-white transition i.e. during obesity which may be a driving factor of cardiovascular disease. In this review we discuss the risks of excess cardiac and vascular adiposity and potential mechanisms by which restoring the brown phenotype i.e. “re-browning” could potentially be achieved in clinically relevant populations. |
| first_indexed | 2025-11-14T19:39:07Z |
| format | Article |
| id | nottingham-39635 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:39:07Z |
| publishDate | 2017 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-396352020-05-04T18:27:50Z https://eprints.nottingham.ac.uk/39635/ ‘Browning’ the cardiac and peri-vascular adipose tissues to modulate cardiovascular risk Aldiss, Peter Davies, Graeme Woods, Rachel Budge, Helen Sacks, Harold S. Symonds, Michael E. Excess visceral adiposity, in particular that located adjacent to the heart and coronary arteries is associated with increased cardiovascular risk. In the pathophysiological state, dysfunctional adipose tissue secretes an array of factors modulating vascular function and driving atherogenesis. Conversely, brown and beige adipose tissues utilise glucose and lipids to generate heat and are associated with improved cardiometabolic health. The cardiac and thoracic perivascular adipose tissues are now understood to be composed of brown adipose tissue in the healthy state and undergo a brown-to-white transition i.e. during obesity which may be a driving factor of cardiovascular disease. In this review we discuss the risks of excess cardiac and vascular adiposity and potential mechanisms by which restoring the brown phenotype i.e. “re-browning” could potentially be achieved in clinically relevant populations. Elsevier 2017-02-01 Article PeerReviewed Aldiss, Peter, Davies, Graeme, Woods, Rachel, Budge, Helen, Sacks, Harold S. and Symonds, Michael E. (2017) ‘Browning’ the cardiac and peri-vascular adipose tissues to modulate cardiovascular risk. International Journal of Cardiology, 228 . pp. 265-274. ISSN 1874-1754 Epicardial adipose tissue; Perivascular adipose tissue; Brown adipose tissue; CVD http://www.sciencedirect.com/science/article/pii/S0167527316335203 doi:10.1016/j.ijcard.2016.11.074 doi:10.1016/j.ijcard.2016.11.074 |
| spellingShingle | Epicardial adipose tissue; Perivascular adipose tissue; Brown adipose tissue; CVD Aldiss, Peter Davies, Graeme Woods, Rachel Budge, Helen Sacks, Harold S. Symonds, Michael E. ‘Browning’ the cardiac and peri-vascular adipose tissues to modulate cardiovascular risk |
| title | ‘Browning’ the cardiac and peri-vascular adipose tissues to modulate cardiovascular risk |
| title_full | ‘Browning’ the cardiac and peri-vascular adipose tissues to modulate cardiovascular risk |
| title_fullStr | ‘Browning’ the cardiac and peri-vascular adipose tissues to modulate cardiovascular risk |
| title_full_unstemmed | ‘Browning’ the cardiac and peri-vascular adipose tissues to modulate cardiovascular risk |
| title_short | ‘Browning’ the cardiac and peri-vascular adipose tissues to modulate cardiovascular risk |
| title_sort | ‘browning’ the cardiac and peri-vascular adipose tissues to modulate cardiovascular risk |
| topic | Epicardial adipose tissue; Perivascular adipose tissue; Brown adipose tissue; CVD |
| url | https://eprints.nottingham.ac.uk/39635/ https://eprints.nottingham.ac.uk/39635/ https://eprints.nottingham.ac.uk/39635/ |