Imaging gray matter with concomitant null point imaging from the phase sensitive inversion recovery sequence
Purpose To present an improved three-dimensional (3D) interleaved phase sensitive inversion recovery (PSIR) sequence including a concomitantly acquired new contrast, null point imaging (NPI), to help detect and classify abnormalities in cortical gray matter. Methods The 3D gradient echo PSIR...
| Main Authors: | , , , , , |
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| Format: | Article |
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Wiley
2016
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| Online Access: | https://eprints.nottingham.ac.uk/39591/ |
| _version_ | 1848795871894831104 |
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| author | Mougin, Olivier Abdel-Fahim, Rasha Dineen, Robert Pitiot, Alain Evangelou, Nikos Gowland, Penny A. |
| author_facet | Mougin, Olivier Abdel-Fahim, Rasha Dineen, Robert Pitiot, Alain Evangelou, Nikos Gowland, Penny A. |
| author_sort | Mougin, Olivier |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Purpose
To present an improved three-dimensional (3D) interleaved phase sensitive inversion recovery (PSIR) sequence including a concomitantly acquired new contrast, null point imaging (NPI), to help detect and classify abnormalities in cortical gray matter.
Methods
The 3D gradient echo PSIR images were acquired at 0.6 mm isotropic resolution on 11 multiple sclerosis (MS) patients and 9 controls subjects using a 7 Tesla (T) MRI scanner, and 2 MS patients at 3T. Cortical abnormalities were delineated on the NPI/PSIR data and later classified according to position in the cortex.
Results
The NPI helped detect cortical lesions within the cortical ribbon with increased, positive contrast compared with the PSIR. It also provided improved intrinsic delineation of the ribbon, increasing confidence in classifying the lesions' locations.
Conclusion
The proposed PSIR facilitates the classification of cortical lesions by providing two T1-weighted 3D datasets with isotropic resolution, including the NPI showing cortical lesions with clear delineation of the gray/white matter boundary and minimal partial volume effects. Magn Reson Med 76:1512–1516, 2016. © 2015 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| first_indexed | 2025-11-14T19:38:59Z |
| format | Article |
| id | nottingham-39591 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:38:59Z |
| publishDate | 2016 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-395912020-05-04T20:00:08Z https://eprints.nottingham.ac.uk/39591/ Imaging gray matter with concomitant null point imaging from the phase sensitive inversion recovery sequence Mougin, Olivier Abdel-Fahim, Rasha Dineen, Robert Pitiot, Alain Evangelou, Nikos Gowland, Penny A. Purpose To present an improved three-dimensional (3D) interleaved phase sensitive inversion recovery (PSIR) sequence including a concomitantly acquired new contrast, null point imaging (NPI), to help detect and classify abnormalities in cortical gray matter. Methods The 3D gradient echo PSIR images were acquired at 0.6 mm isotropic resolution on 11 multiple sclerosis (MS) patients and 9 controls subjects using a 7 Tesla (T) MRI scanner, and 2 MS patients at 3T. Cortical abnormalities were delineated on the NPI/PSIR data and later classified according to position in the cortex. Results The NPI helped detect cortical lesions within the cortical ribbon with increased, positive contrast compared with the PSIR. It also provided improved intrinsic delineation of the ribbon, increasing confidence in classifying the lesions' locations. Conclusion The proposed PSIR facilitates the classification of cortical lesions by providing two T1-weighted 3D datasets with isotropic resolution, including the NPI showing cortical lesions with clear delineation of the gray/white matter boundary and minimal partial volume effects. Magn Reson Med 76:1512–1516, 2016. © 2015 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Wiley 2016-11 Article PeerReviewed Mougin, Olivier, Abdel-Fahim, Rasha, Dineen, Robert, Pitiot, Alain, Evangelou, Nikos and Gowland, Penny A. (2016) Imaging gray matter with concomitant null point imaging from the phase sensitive inversion recovery sequence. Magnetic Resonance in Medicine, 76 (5). pp. 1512-1516. ISSN 1522-2594 magnetic resonance imaging; multiple sclerosis; cerebral cortex; imaging; gray matter http://onlinelibrary.wiley.com/doi/10.1002/mrm.26061/abstract 10.1002/mrm.26061 10.1002/mrm.26061 10.1002/mrm.26061 |
| spellingShingle | magnetic resonance imaging; multiple sclerosis; cerebral cortex; imaging; gray matter Mougin, Olivier Abdel-Fahim, Rasha Dineen, Robert Pitiot, Alain Evangelou, Nikos Gowland, Penny A. Imaging gray matter with concomitant null point imaging from the phase sensitive inversion recovery sequence |
| title | Imaging gray matter with concomitant null point imaging from the phase sensitive inversion recovery sequence |
| title_full | Imaging gray matter with concomitant null point imaging from the phase sensitive inversion recovery sequence |
| title_fullStr | Imaging gray matter with concomitant null point imaging from the phase sensitive inversion recovery sequence |
| title_full_unstemmed | Imaging gray matter with concomitant null point imaging from the phase sensitive inversion recovery sequence |
| title_short | Imaging gray matter with concomitant null point imaging from the phase sensitive inversion recovery sequence |
| title_sort | imaging gray matter with concomitant null point imaging from the phase sensitive inversion recovery sequence |
| topic | magnetic resonance imaging; multiple sclerosis; cerebral cortex; imaging; gray matter |
| url | https://eprints.nottingham.ac.uk/39591/ https://eprints.nottingham.ac.uk/39591/ https://eprints.nottingham.ac.uk/39591/ |