Corneal keratocyte transition to mesenchymal stem cell phenotype and reversal using serum-free medium supplemented with FGF-2, TGF-ß3 and retinoic acid

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Corneal keratocyte transition to mesenchymal stem cell phenotype and reversal using serum-free medium supplemented with FGF-2, TGF-ß3 and retinoic acid

Keratocytes of the corneal limbal stroma can derive populations of mesenchymal stem cells (MSC) when expanded in vitro. However, once a corneal MSC (cMSC) phenotype is achieved, regaining the keratocyte phenotype can be challenging, and there is no standardised differentiation medium. Here, we inves...

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Bibliographic Details
Main Authors:	Sidney, Laura E., Hopkinson, A.
Format:	Article
Published:	Wiley 2016
Subjects:	cornea; mesenchymal stem cells; corneal stromal stem cells; keratocyte; differentiation; phenotype; extracellular matrix; serum-free culture
Online Access:	https://eprints.nottingham.ac.uk/39574/

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