Surface-enhanced Raman spectroscopy study of 4-ATP on gold nanoparticles for basal cell carcinoma fingerprint detection
The surface-enhanced Raman signals of 4-aminothiophenol (4-ATP) attached to the surface of colloidal gold nanoparticles with size distribution of 2 to 5 nm were used as a labeling agent to detect basal cell carcinoma (BCC) of the skin. The enhanced Raman band at 1075 cm-1 corresponding to the C-S st...
| Main Authors: | , , , , , , |
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| Format: | Article |
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Springer
2016
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| Online Access: | https://eprints.nottingham.ac.uk/39516/ |
| _version_ | 1848795855191015424 |
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| author | Quynh, Luu Manh Nam, Nguyen Hoang Kong, K. Nhung, Nguyen Thi Notingher, Ioan Henini, M. Luong, Nguyen Hoang |
| author_facet | Quynh, Luu Manh Nam, Nguyen Hoang Kong, K. Nhung, Nguyen Thi Notingher, Ioan Henini, M. Luong, Nguyen Hoang |
| author_sort | Quynh, Luu Manh |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The surface-enhanced Raman signals of 4-aminothiophenol (4-ATP) attached to the surface of colloidal gold nanoparticles with size distribution of 2 to 5 nm were used as a labeling agent to detect basal cell carcinoma (BCC) of the skin. The enhanced Raman band at 1075 cm-1 corresponding to the C-S stretching vibration in 4-ATP was observed during attachment to the surface of the gold nanoparticles. The frequency and intensity of this band did not change when the colloids were conjugated with BerEP4 antibody, which specifically binds to BCC. We show the feasibility of imaging BCC by surface-enhanced Raman spectroscopy, scanning the 1075 cm-1 band to detect the distribution of 4ATP-coated gold nanoparticles attached to skin tissue ex vivo. |
| first_indexed | 2025-11-14T19:38:43Z |
| format | Article |
| id | nottingham-39516 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:38:43Z |
| publishDate | 2016 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-395162020-05-04T17:49:18Z https://eprints.nottingham.ac.uk/39516/ Surface-enhanced Raman spectroscopy study of 4-ATP on gold nanoparticles for basal cell carcinoma fingerprint detection Quynh, Luu Manh Nam, Nguyen Hoang Kong, K. Nhung, Nguyen Thi Notingher, Ioan Henini, M. Luong, Nguyen Hoang The surface-enhanced Raman signals of 4-aminothiophenol (4-ATP) attached to the surface of colloidal gold nanoparticles with size distribution of 2 to 5 nm were used as a labeling agent to detect basal cell carcinoma (BCC) of the skin. The enhanced Raman band at 1075 cm-1 corresponding to the C-S stretching vibration in 4-ATP was observed during attachment to the surface of the gold nanoparticles. The frequency and intensity of this band did not change when the colloids were conjugated with BerEP4 antibody, which specifically binds to BCC. We show the feasibility of imaging BCC by surface-enhanced Raman spectroscopy, scanning the 1075 cm-1 band to detect the distribution of 4ATP-coated gold nanoparticles attached to skin tissue ex vivo. Springer 2016-05-31 Article PeerReviewed Quynh, Luu Manh, Nam, Nguyen Hoang, Kong, K., Nhung, Nguyen Thi, Notingher, Ioan, Henini, M. and Luong, Nguyen Hoang (2016) Surface-enhanced Raman spectroscopy study of 4-ATP on gold nanoparticles for basal cell carcinoma fingerprint detection. Journal of Electronic Materials, 45 (5). pp. 2563-2568. ISSN 1543-186X Skin cancer Basal cell carcinoma Surface-enhanced Raman scattering Gold nanoparticles http://link.springer.com/article/10.1007/s11664-016-4421-9 doi:10.1007/s11664-016-4421-9 doi:10.1007/s11664-016-4421-9 |
| spellingShingle | Skin cancer Basal cell carcinoma Surface-enhanced Raman scattering Gold nanoparticles Quynh, Luu Manh Nam, Nguyen Hoang Kong, K. Nhung, Nguyen Thi Notingher, Ioan Henini, M. Luong, Nguyen Hoang Surface-enhanced Raman spectroscopy study of 4-ATP on gold nanoparticles for basal cell carcinoma fingerprint detection |
| title | Surface-enhanced Raman spectroscopy study of 4-ATP on gold nanoparticles for basal cell carcinoma fingerprint detection |
| title_full | Surface-enhanced Raman spectroscopy study of 4-ATP on gold nanoparticles for basal cell carcinoma fingerprint detection |
| title_fullStr | Surface-enhanced Raman spectroscopy study of 4-ATP on gold nanoparticles for basal cell carcinoma fingerprint detection |
| title_full_unstemmed | Surface-enhanced Raman spectroscopy study of 4-ATP on gold nanoparticles for basal cell carcinoma fingerprint detection |
| title_short | Surface-enhanced Raman spectroscopy study of 4-ATP on gold nanoparticles for basal cell carcinoma fingerprint detection |
| title_sort | surface-enhanced raman spectroscopy study of 4-atp on gold nanoparticles for basal cell carcinoma fingerprint detection |
| topic | Skin cancer Basal cell carcinoma Surface-enhanced Raman scattering Gold nanoparticles |
| url | https://eprints.nottingham.ac.uk/39516/ https://eprints.nottingham.ac.uk/39516/ https://eprints.nottingham.ac.uk/39516/ |