Mapping quantal touch using 7 Tesla functional magnetic resonance imaging and single-unit intraneural microstimulation.
Using ultra-high field 7 Tesla (7T) functional magnetic resonance imaging (fMRI), we map the cortical and perceptual responses elicited by intraneural microstimulation (INMS) of single mechanoreceptive afferent units in the median nerve, in humans. Activations are compared to those produced by apply...
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| Format: | Article |
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eLife Sciences Publications
2016
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| Online Access: | https://eprints.nottingham.ac.uk/39481/ |
| _version_ | 1848795847105445888 |
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| author | Sanchez Panchuelo, Rosa Ackerley, Rochelle M. Glover, Paul M. Bowtell, Richard W. Wessberg, Johan Francis, Susan T. McGlone, Francis |
| author_facet | Sanchez Panchuelo, Rosa Ackerley, Rochelle M. Glover, Paul M. Bowtell, Richard W. Wessberg, Johan Francis, Susan T. McGlone, Francis |
| author_sort | Sanchez Panchuelo, Rosa |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Using ultra-high field 7 Tesla (7T) functional magnetic resonance imaging (fMRI), we map the cortical and perceptual responses elicited by intraneural microstimulation (INMS) of single mechanoreceptive afferent units in the median nerve, in humans. Activations are compared to those produced by applying vibrotactile stimulation to the unit’s receptive field, and unit-type perceptual reports are analyzed. We show that INMS and vibrotactile stimulation engage overlapping areas within the topographically appropriate digit representation in the primary somatosensory cortex. Additional brain regions in bilateral secondary somatosensory cortex, premotor cortex, primary motor cortex, insula and posterior parietal cortex, as well as in contralateral prefrontal cortex are also shown to be activated in response to INMS. The combination of INMS and 7T fMRI opens up an unprecedented opportunity to bridge the gap between first-order mechanoreceptive afferent input codes and their spatial, dynamic and perceptual representations in human cortex. |
| first_indexed | 2025-11-14T19:38:35Z |
| format | Article |
| id | nottingham-39481 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:38:35Z |
| publishDate | 2016 |
| publisher | eLife Sciences Publications |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-394812020-05-04T17:52:51Z https://eprints.nottingham.ac.uk/39481/ Mapping quantal touch using 7 Tesla functional magnetic resonance imaging and single-unit intraneural microstimulation. Sanchez Panchuelo, Rosa Ackerley, Rochelle M. Glover, Paul M. Bowtell, Richard W. Wessberg, Johan Francis, Susan T. McGlone, Francis Using ultra-high field 7 Tesla (7T) functional magnetic resonance imaging (fMRI), we map the cortical and perceptual responses elicited by intraneural microstimulation (INMS) of single mechanoreceptive afferent units in the median nerve, in humans. Activations are compared to those produced by applying vibrotactile stimulation to the unit’s receptive field, and unit-type perceptual reports are analyzed. We show that INMS and vibrotactile stimulation engage overlapping areas within the topographically appropriate digit representation in the primary somatosensory cortex. Additional brain regions in bilateral secondary somatosensory cortex, premotor cortex, primary motor cortex, insula and posterior parietal cortex, as well as in contralateral prefrontal cortex are also shown to be activated in response to INMS. The combination of INMS and 7T fMRI opens up an unprecedented opportunity to bridge the gap between first-order mechanoreceptive afferent input codes and their spatial, dynamic and perceptual representations in human cortex. eLife Sciences Publications 2016-05-07 Article PeerReviewed Sanchez Panchuelo, Rosa, Ackerley, Rochelle M., Glover, Paul M., Bowtell, Richard W., Wessberg, Johan, Francis, Susan T. and McGlone, Francis (2016) Mapping quantal touch using 7 Tesla functional magnetic resonance imaging and single-unit intraneural microstimulation. eLife, 5 (e12812). ISSN 2050-084X touch microneurography intraneural microstimulation peripheral nerves hand tactile fMRI ultra-high field https://elifesciences.org/content/5/e12812 doi:10.7554/eLife.12812 doi:10.7554/eLife.12812 |
| spellingShingle | touch microneurography intraneural microstimulation peripheral nerves hand tactile fMRI ultra-high field Sanchez Panchuelo, Rosa Ackerley, Rochelle M. Glover, Paul M. Bowtell, Richard W. Wessberg, Johan Francis, Susan T. McGlone, Francis Mapping quantal touch using 7 Tesla functional magnetic resonance imaging and single-unit intraneural microstimulation. |
| title | Mapping quantal touch using 7 Tesla functional magnetic resonance imaging and single-unit intraneural microstimulation. |
| title_full | Mapping quantal touch using 7 Tesla functional magnetic resonance imaging and single-unit intraneural microstimulation. |
| title_fullStr | Mapping quantal touch using 7 Tesla functional magnetic resonance imaging and single-unit intraneural microstimulation. |
| title_full_unstemmed | Mapping quantal touch using 7 Tesla functional magnetic resonance imaging and single-unit intraneural microstimulation. |
| title_short | Mapping quantal touch using 7 Tesla functional magnetic resonance imaging and single-unit intraneural microstimulation. |
| title_sort | mapping quantal touch using 7 tesla functional magnetic resonance imaging and single-unit intraneural microstimulation. |
| topic | touch microneurography intraneural microstimulation peripheral nerves hand tactile fMRI ultra-high field |
| url | https://eprints.nottingham.ac.uk/39481/ https://eprints.nottingham.ac.uk/39481/ https://eprints.nottingham.ac.uk/39481/ |