Pharmacology of modulators of alternative splicing
More than 95% of genes in the human genome are alternatively spliced to form multiple transcripts, often encoding proteins with differing or opposing function. The control of alternative splicing is now being elucidated, and with this comes the opportunity to develop modulators of alternative splici...
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| Format: | Article |
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American Society for Pharmacology and Experimental Therapeutics
2017
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| Online Access: | https://eprints.nottingham.ac.uk/39444/ |
| _version_ | 1848795837640998912 |
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| author | Bates, David O. Morris, Jonathan C. Oltean, Sebastian Donaldson, Lucy F. |
| author_facet | Bates, David O. Morris, Jonathan C. Oltean, Sebastian Donaldson, Lucy F. |
| author_sort | Bates, David O. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | More than 95% of genes in the human genome are alternatively spliced to form multiple transcripts, often encoding proteins with differing or opposing function. The control of alternative splicing is now being elucidated, and with this comes the opportunity to develop modulators of alternative splicing that can control cellular function. A number of approaches have been taken to develop compounds that can experimentally, and sometimes clinically, affect splicing control resulting in potential novel therapeutics. Here we develop the concepts that targeting alternative splicing can result in relatively specific pathway inhibitors/activators that result in dampening down of physiological or pathological processes, from changes in muscle physiology, to altering angiogenesis or pain. The targets and pharmacology of some of the current inhibitors/activators of alternative splicing are demonstrated and future directions discussed. |
| first_indexed | 2025-11-14T19:38:26Z |
| format | Article |
| id | nottingham-39444 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:38:26Z |
| publishDate | 2017 |
| publisher | American Society for Pharmacology and Experimental Therapeutics |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-394442020-05-04T18:22:44Z https://eprints.nottingham.ac.uk/39444/ Pharmacology of modulators of alternative splicing Bates, David O. Morris, Jonathan C. Oltean, Sebastian Donaldson, Lucy F. More than 95% of genes in the human genome are alternatively spliced to form multiple transcripts, often encoding proteins with differing or opposing function. The control of alternative splicing is now being elucidated, and with this comes the opportunity to develop modulators of alternative splicing that can control cellular function. A number of approaches have been taken to develop compounds that can experimentally, and sometimes clinically, affect splicing control resulting in potential novel therapeutics. Here we develop the concepts that targeting alternative splicing can result in relatively specific pathway inhibitors/activators that result in dampening down of physiological or pathological processes, from changes in muscle physiology, to altering angiogenesis or pain. The targets and pharmacology of some of the current inhibitors/activators of alternative splicing are demonstrated and future directions discussed. American Society for Pharmacology and Experimental Therapeutics 2017-01-01 Article PeerReviewed Bates, David O., Morris, Jonathan C., Oltean, Sebastian and Donaldson, Lucy F. (2017) Pharmacology of modulators of alternative splicing. Pharmacological Reviews, 69 (1). pp. 63-79. ISSN 1521-0081 http://pharmrev.aspetjournals.org/content/69/1/63 doi:10.1124/pr.115.011239 doi:10.1124/pr.115.011239 |
| spellingShingle | Bates, David O. Morris, Jonathan C. Oltean, Sebastian Donaldson, Lucy F. Pharmacology of modulators of alternative splicing |
| title | Pharmacology of modulators of alternative splicing |
| title_full | Pharmacology of modulators of alternative splicing |
| title_fullStr | Pharmacology of modulators of alternative splicing |
| title_full_unstemmed | Pharmacology of modulators of alternative splicing |
| title_short | Pharmacology of modulators of alternative splicing |
| title_sort | pharmacology of modulators of alternative splicing |
| url | https://eprints.nottingham.ac.uk/39444/ https://eprints.nottingham.ac.uk/39444/ https://eprints.nottingham.ac.uk/39444/ |