Expression and regulation of immune-modulatory enzyme Indoleamine 2,3-dioxygenase (IDO) by human airway epithelial cells and its effect on T cell activation

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Expression and regulation of immune-modulatory enzyme Indoleamine 2,3-dioxygenase (IDO) by human airway epithelial cells and its effect on T cell activation

Indoleamine 2,3-dioxygenase (IDO) catalyzes the degradation of tryptophan, which plays a critical role in immune suppression through regulating the production of a series of metabolites that are generally referred to as kynurenines. It has become increasingly clear that epithelial cells (ECs) play a...

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Bibliographic Details
Main Authors:	Aldajani, Wejdan A., Salazar, Fabian, Sewell, Herb F., Knox, Alan, Ghaemmaghami, Amir M.
Format:	Article
Published:	Impact Journals 2016
Subjects:	epithelial cells; indoleamine 2 3-dioxygenase; T cell proliferation; allergen; Immunology and Microbiology Section; Immune response; Immunity
Online Access:	https://eprints.nottingham.ac.uk/39324/

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