One-pot ligation-oxidative deselenization at selenocysteine and selenocystine

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One-pot ligation-oxidative deselenization at selenocysteine and selenocystine

The use of native chemical ligation at selenocysteine (Sec) with peptide thioesters and additive-free selenocystine ligation with peptides bearing phenyl selenoesters, in concert with one-pot oxidative deselenization chemistry, is described. These approaches provide a simple and rapid method for acc...

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Bibliographic Details
Main Authors:	Payne, Richard J., Mitchell, Nicholas J., Kulkarni, Sameer S., Wang, Siyao, Malins, Lara
Format:	Article
Published:	Wiley 2017
Subjects:	Peptides Ligation Oxidative Deselenization Glycopeptides Synthesis
Online Access:	https://eprints.nottingham.ac.uk/39311/

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