One-pot ligation-oxidative deselenization at selenocysteine and selenocystine
The use of native chemical ligation at selenocysteine (Sec) with peptide thioesters and additive-free selenocystine ligation with peptides bearing phenyl selenoesters, in concert with one-pot oxidative deselenization chemistry, is described. These approaches provide a simple and rapid method for acc...
| Main Authors: | , , , , |
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| Format: | Article |
| Published: |
Wiley
2017
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| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/39311/ |
| Summary: | The use of native chemical ligation at selenocysteine (Sec) with peptide thioesters and additive-free selenocystine ligation with peptides bearing phenyl selenoesters, in concert with one-pot oxidative deselenization chemistry, is described. These approaches provide a simple and rapid method for accessing native peptides with serine in place of Sec at the ligation junction. The efficiency of both variants of the one-pot ligation-oxidative deselenization chemistry is probed through the synthesis of a MUC5AC-derived glycopeptide. |
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