Cancer subtype identification pipeline: a classifusion approach

Classification of cancer patients into treatment groups is essential for appropriate diagnosis to increase survival. Previously, a series of papers, largely published in the breast cancer domain have leveraged Computational Intelligence (CI) developments and tools, resulting in ground breaking advan...

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Main Authors: Agrawal, Utkarsh, Soria, Daniele, Wagner, Christian
Format: Conference or Workshop Item
Published: 2016
Subjects:
Online Access:https://eprints.nottingham.ac.uk/39199/
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author Agrawal, Utkarsh
Soria, Daniele
Wagner, Christian
author_facet Agrawal, Utkarsh
Soria, Daniele
Wagner, Christian
author_sort Agrawal, Utkarsh
building Nottingham Research Data Repository
collection Online Access
description Classification of cancer patients into treatment groups is essential for appropriate diagnosis to increase survival. Previously, a series of papers, largely published in the breast cancer domain have leveraged Computational Intelligence (CI) developments and tools, resulting in ground breaking advances such as the classification of cancer into newly identified classes - leading to improved treatment options. However, the current literature on the use of CI to achieve this is fragmented, making further advances challenging. This paper captures developments in this area so far, with the goal to establish a clear, step-by-step pipeline for cancer subtype identification. Based on establishing the pipeline, the paper identifies key potential advances in CI at the individual steps, thus establishing a roadmap for future research. As such, it is the aim of the paper to engage the CI community to address the research challenges and leverage the strong potential of CI in this important area. Finally, we present a small set of recent findings on the Nottingham Tenovus Primary Breast Carcinoma Series enabling the classification of a higher number of patients into one of the identified breast cancer groups, and introduce Classifusion: a combination of results of multiple classifiers.
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publishDate 2016
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spelling nottingham-391992020-05-04T18:20:21Z https://eprints.nottingham.ac.uk/39199/ Cancer subtype identification pipeline: a classifusion approach Agrawal, Utkarsh Soria, Daniele Wagner, Christian Classification of cancer patients into treatment groups is essential for appropriate diagnosis to increase survival. Previously, a series of papers, largely published in the breast cancer domain have leveraged Computational Intelligence (CI) developments and tools, resulting in ground breaking advances such as the classification of cancer into newly identified classes - leading to improved treatment options. However, the current literature on the use of CI to achieve this is fragmented, making further advances challenging. This paper captures developments in this area so far, with the goal to establish a clear, step-by-step pipeline for cancer subtype identification. Based on establishing the pipeline, the paper identifies key potential advances in CI at the individual steps, thus establishing a roadmap for future research. As such, it is the aim of the paper to engage the CI community to address the research challenges and leverage the strong potential of CI in this important area. Finally, we present a small set of recent findings on the Nottingham Tenovus Primary Breast Carcinoma Series enabling the classification of a higher number of patients into one of the identified breast cancer groups, and introduce Classifusion: a combination of results of multiple classifiers. 2016-11-21 Conference or Workshop Item PeerReviewed Agrawal, Utkarsh, Soria, Daniele and Wagner, Christian (2016) Cancer subtype identification pipeline: a classifusion approach. In: 2016 IEEE Congress on Evolutionary Computation (CEC), 24-29 July 2016, Vancouver, Canada. Breast Cancer; Classification methods; Consensus Classification (Classifusion); Consensus Clustering http://ieeexplore.ieee.org/document/7744150/
spellingShingle Breast Cancer; Classification methods; Consensus Classification (Classifusion); Consensus Clustering
Agrawal, Utkarsh
Soria, Daniele
Wagner, Christian
Cancer subtype identification pipeline: a classifusion approach
title Cancer subtype identification pipeline: a classifusion approach
title_full Cancer subtype identification pipeline: a classifusion approach
title_fullStr Cancer subtype identification pipeline: a classifusion approach
title_full_unstemmed Cancer subtype identification pipeline: a classifusion approach
title_short Cancer subtype identification pipeline: a classifusion approach
title_sort cancer subtype identification pipeline: a classifusion approach
topic Breast Cancer; Classification methods; Consensus Classification (Classifusion); Consensus Clustering
url https://eprints.nottingham.ac.uk/39199/
https://eprints.nottingham.ac.uk/39199/