Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury
It is likely that the majority of proteins will undergo post-translational modification, be it enzymatic or non-enzymatic. These modified protein(s) regulate activity, localization and interaction with other cellular molecules thereby maintaining cellular hemostasis. Alcohol exposure significantly a...
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| Format: | Article |
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Baishideng Publishing Group
2016
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| Online Access: | https://eprints.nottingham.ac.uk/39167/ |
| _version_ | 1848795778561081344 |
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| author | Osna, Natalie Carter, Wayne Ganesan, Murali Kirpich, Irina A. McClain, Criag J. Petersen, Dennis R. Shearn, Colin T. Tomasi, Maria L. Kharbanda, Kusum |
| author_facet | Osna, Natalie Carter, Wayne Ganesan, Murali Kirpich, Irina A. McClain, Criag J. Petersen, Dennis R. Shearn, Colin T. Tomasi, Maria L. Kharbanda, Kusum |
| author_sort | Osna, Natalie |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | It is likely that the majority of proteins will undergo post-translational modification, be it enzymatic or non-enzymatic. These modified protein(s) regulate activity, localization and interaction with other cellular molecules thereby maintaining cellular hemostasis. Alcohol exposure significantly alters several of these post-translational modifications leading to impairments of many essential physiological processes. Here, we present new insights into novel modifications following ethanol exposure and their role in the initiation and progression of liver injury. This critical review condenses the proceedings of a symposium at the European Society for the Biomedical Research on Alcoholism Meeting held September 12-15, 2015, in Valencia, Spain. |
| first_indexed | 2025-11-14T19:37:30Z |
| format | Article |
| id | nottingham-39167 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:37:30Z |
| publishDate | 2016 |
| publisher | Baishideng Publishing Group |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-391672020-05-04T17:55:49Z https://eprints.nottingham.ac.uk/39167/ Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury Osna, Natalie Carter, Wayne Ganesan, Murali Kirpich, Irina A. McClain, Criag J. Petersen, Dennis R. Shearn, Colin T. Tomasi, Maria L. Kharbanda, Kusum It is likely that the majority of proteins will undergo post-translational modification, be it enzymatic or non-enzymatic. These modified protein(s) regulate activity, localization and interaction with other cellular molecules thereby maintaining cellular hemostasis. Alcohol exposure significantly alters several of these post-translational modifications leading to impairments of many essential physiological processes. Here, we present new insights into novel modifications following ethanol exposure and their role in the initiation and progression of liver injury. This critical review condenses the proceedings of a symposium at the European Society for the Biomedical Research on Alcoholism Meeting held September 12-15, 2015, in Valencia, Spain. Baishideng Publishing Group 2016-06-21 Article PeerReviewed Osna, Natalie, Carter, Wayne, Ganesan, Murali, Kirpich, Irina A., McClain, Criag J., Petersen, Dennis R., Shearn, Colin T., Tomasi, Maria L. and Kharbanda, Kusum (2016) Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury. World Journal of Gastroenterology, 22 (27). pp. 6192-6200. ISSN 2219-2840 Alcohol; Acetylation; Liver; Carbonylation methylation; Dysfunction; Methylation; Glycosylation; Phosphorylation; Ubiquitination; Sumoylation; Betaine; Post-translational protein modification http://www.wjgnet.com/1007-9327/full/v22/i27/6192.htm doi:10.3748/wjg.v22.i27.6192 doi:10.3748/wjg.v22.i27.6192 |
| spellingShingle | Alcohol; Acetylation; Liver; Carbonylation methylation; Dysfunction; Methylation; Glycosylation; Phosphorylation; Ubiquitination; Sumoylation; Betaine; Post-translational protein modification Osna, Natalie Carter, Wayne Ganesan, Murali Kirpich, Irina A. McClain, Criag J. Petersen, Dennis R. Shearn, Colin T. Tomasi, Maria L. Kharbanda, Kusum Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury |
| title | Aberrant post-translational protein modifications in the
pathogenesis of alcohol-induced liver injury |
| title_full | Aberrant post-translational protein modifications in the
pathogenesis of alcohol-induced liver injury |
| title_fullStr | Aberrant post-translational protein modifications in the
pathogenesis of alcohol-induced liver injury |
| title_full_unstemmed | Aberrant post-translational protein modifications in the
pathogenesis of alcohol-induced liver injury |
| title_short | Aberrant post-translational protein modifications in the
pathogenesis of alcohol-induced liver injury |
| title_sort | aberrant post-translational protein modifications in the
pathogenesis of alcohol-induced liver injury |
| topic | Alcohol; Acetylation; Liver; Carbonylation methylation; Dysfunction; Methylation; Glycosylation; Phosphorylation; Ubiquitination; Sumoylation; Betaine; Post-translational protein modification |
| url | https://eprints.nottingham.ac.uk/39167/ https://eprints.nottingham.ac.uk/39167/ https://eprints.nottingham.ac.uk/39167/ |