Heritability of non-speech auditory processing skills
Recent insight into the genetic bases for autism spectrum disorder, dyslexia, stuttering, and language disorders suggest that neurogenetic approaches may also reveal at least one etiology of auditory processing disorder (APD). A person with an APD typically has difficulty understanding speech in bac...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
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Nature Publishing Group
2016
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| Online Access: | https://eprints.nottingham.ac.uk/39118/ |
| _version_ | 1848795767133700096 |
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| author | Brewer, Carmen C. Zalewski, Christopher K. King, Kelly A. Zobay, Oliver Riley, Alison Ferguson, Melanie A. Bird, Jonathan E. McCabe, Margaret M. Hood, Linda J. Drayna, Dennis Griffith, Andrew J. Morell, Robert J. Friedman, Thomas B. Moore, David R. |
| author_facet | Brewer, Carmen C. Zalewski, Christopher K. King, Kelly A. Zobay, Oliver Riley, Alison Ferguson, Melanie A. Bird, Jonathan E. McCabe, Margaret M. Hood, Linda J. Drayna, Dennis Griffith, Andrew J. Morell, Robert J. Friedman, Thomas B. Moore, David R. |
| author_sort | Brewer, Carmen C. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Recent insight into the genetic bases for autism spectrum disorder, dyslexia, stuttering, and language disorders suggest that neurogenetic approaches may also reveal at least one etiology of auditory processing disorder (APD). A person with an APD typically has difficulty understanding speech in background noise despite having normal pure-tone hearing sensitivity. The estimated prevalence of APD may be as high as 10% in the pediatric population, yet the causes are unknown and have not been explored by molecular or genetic approaches. The aim of our study was to determine the heritability of frequency and temporal resolution for auditory signals and speech recognition in noise in 96 identical or fraternal twin pairs, aged 6–11 years. Measures of auditory processing (AP) of non-speech sounds included backward masking (temporal resolution), notched noise masking (spectral resolution), pure-tone frequency discrimination (temporal fine structure sensitivity), and nonsense syllable recognition in noise. We provide evidence of significant heritability, ranging from 0.32 to 0.74, for individual measures of these non-speech-based AP skills that are crucial for understanding spoken language. Identification of specific heritable AP traits such as these serve as a basis to pursue the genetic underpinnings of APD by identifying genetic variants associated with common AP disorders in children and adults. |
| first_indexed | 2025-11-14T19:37:19Z |
| format | Article |
| id | nottingham-39118 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:37:19Z |
| publishDate | 2016 |
| publisher | Nature Publishing Group |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-391182020-05-04T18:04:59Z https://eprints.nottingham.ac.uk/39118/ Heritability of non-speech auditory processing skills Brewer, Carmen C. Zalewski, Christopher K. King, Kelly A. Zobay, Oliver Riley, Alison Ferguson, Melanie A. Bird, Jonathan E. McCabe, Margaret M. Hood, Linda J. Drayna, Dennis Griffith, Andrew J. Morell, Robert J. Friedman, Thomas B. Moore, David R. Recent insight into the genetic bases for autism spectrum disorder, dyslexia, stuttering, and language disorders suggest that neurogenetic approaches may also reveal at least one etiology of auditory processing disorder (APD). A person with an APD typically has difficulty understanding speech in background noise despite having normal pure-tone hearing sensitivity. The estimated prevalence of APD may be as high as 10% in the pediatric population, yet the causes are unknown and have not been explored by molecular or genetic approaches. The aim of our study was to determine the heritability of frequency and temporal resolution for auditory signals and speech recognition in noise in 96 identical or fraternal twin pairs, aged 6–11 years. Measures of auditory processing (AP) of non-speech sounds included backward masking (temporal resolution), notched noise masking (spectral resolution), pure-tone frequency discrimination (temporal fine structure sensitivity), and nonsense syllable recognition in noise. We provide evidence of significant heritability, ranging from 0.32 to 0.74, for individual measures of these non-speech-based AP skills that are crucial for understanding spoken language. Identification of specific heritable AP traits such as these serve as a basis to pursue the genetic underpinnings of APD by identifying genetic variants associated with common AP disorders in children and adults. Nature Publishing Group 2016-08-31 Article PeerReviewed Brewer, Carmen C., Zalewski, Christopher K., King, Kelly A., Zobay, Oliver, Riley, Alison, Ferguson, Melanie A., Bird, Jonathan E., McCabe, Margaret M., Hood, Linda J., Drayna, Dennis, Griffith, Andrew J., Morell, Robert J., Friedman, Thomas B. and Moore, David R. (2016) Heritability of non-speech auditory processing skills. European Journal of Human Genetics, 24 (8). pp. 1137-1144. ISSN 1476-5438 Auditory processing; Heritability; Twin study; Frequency discrimination; Backward masking http://dx.doi.org/10.1038/ejhg.2015.277 doi:10.1038/ejhg.2015.277 doi:10.1038/ejhg.2015.277 |
| spellingShingle | Auditory processing; Heritability; Twin study; Frequency discrimination; Backward masking Brewer, Carmen C. Zalewski, Christopher K. King, Kelly A. Zobay, Oliver Riley, Alison Ferguson, Melanie A. Bird, Jonathan E. McCabe, Margaret M. Hood, Linda J. Drayna, Dennis Griffith, Andrew J. Morell, Robert J. Friedman, Thomas B. Moore, David R. Heritability of non-speech auditory processing skills |
| title | Heritability of non-speech auditory processing skills |
| title_full | Heritability of non-speech auditory processing skills |
| title_fullStr | Heritability of non-speech auditory processing skills |
| title_full_unstemmed | Heritability of non-speech auditory processing skills |
| title_short | Heritability of non-speech auditory processing skills |
| title_sort | heritability of non-speech auditory processing skills |
| topic | Auditory processing; Heritability; Twin study; Frequency discrimination; Backward masking |
| url | https://eprints.nottingham.ac.uk/39118/ https://eprints.nottingham.ac.uk/39118/ https://eprints.nottingham.ac.uk/39118/ |