Triblock copolymer nanovesicles for pH-responsive targeted delivery and controlled release of siRNA to cancer cells

QR Code

Triblock copolymer nanovesicles for pH-responsive targeted delivery and controlled release of siRNA to cancer cells

New pH-responsive polymersomes for active anticancer oligonucleotide delivery were prepared from triblock copolymers. The delivery systems were formed by two terminal hydrophilic blocks, PEG and polyglycerolmethacrylate (poly-GMA), and a central weakly basic block, polyimidazole-hexyl methacrylate (...

Full description

Bibliographic Details
Main Authors:	Gallon, Elena, Matini, Teresa, Sasso, Luana, Mantovani, Giuseppe, Armiñan de Benito, Ana, Sanchis, Joaquin, Caliceti, Paolo, Alexander, Cameron, Vicent, Maria J., Salmaso, Stefano
Format:	Article
Published:	American Chemical Society 2015
Online Access:	https://eprints.nottingham.ac.uk/39107/

Similar Items

ABA triblock copolymer flower micelles formulations
by: Almehmady, Alshaimaa
Published: (2018)

Systemic in vivo delivery of siRNA to tumours using combination of polyethyleneimine and transferrin–polyethyleneimine conjugates
by: Grabowska, Anna M., et al.
Published: (2015)

Water-soluble substituted chitosan derivatives as technology platform for inhalation delivery of siRNA
by: Capel, Victoria, et al.
Published: (2018)

Control of targeting ligand display by pH-responsive polymers on gold nanoparticles mediates selective entry into cancer cells
by: Brazzale, C., et al.
Published: (2017)

Phosphonium polymethacrylates for siRNA delivery: effect of polymer and RNA structural parameters on polyplex assembly and gene knockdown
by: Loczenski Rose, Vanessa, et al.
Published: (2015)

Multifunctional poly[N-(2-hydroxypropyl)methacrylamide] copolymers via postpolymerization modification and sequential thiol–ene chemistry
by: Francini, Nora, et al.
Published: (2015)

New biomaterials from renewable resources – amphiphilic block copolymers from δ-decalactone
by: Bansal, Kuldeep K., et al.
Published: (2015)

Pathways of cellular internalisation of liposomes delivered siRNA and effects on siRNA engagement with target mRNA and silencing in cancer cells
by: Alshehri, Abdullah Ali, et al.
Published: (2018)

Switching of macromolecular ligand display by thermoresponsive polymers mediates endocytosis of multi-conjugate nanoparticles
by: Sayers, Edward, et al.
Published: (2018)

In-vitro investigations into endocytosis and silencing of siRNA-liposomes
by: ALSHEHRI, ABDULLAH ALI D
Published: (2017)

Epha2 sirna silencing on malignant glioma cells
by: Azman , Amy Shafinas
Published: (2017)

Dry-powder formulations of non-covalent protein complexes with linear or miktoarm copolymers for pulmonary delivery
by: Nieto-Orellana, Alejandro, et al.
Published: (2018)

Study on Liposomes Integrity and Delivery of siRNA to Lung Cancer
by: Aljasser, Abdullah
Published: (2024)

MysiRNA-designer: a workflow for efficient siRNA design
by: Mysara, Mohamed, et al.
Published: (2011)

Oncogenic signaling in tumorigenesis and applications of siRNA nanotherapeutics in breast cancer
by: Nur Izyani K,, et al.
Published: (2019)

Development and application of a linear polyamidoamine-SiRNA delivery system
by: Fathi, Zainab H
Published: (2018)

Investigating novel cationic polymers for siRNA delivery for treatment of allergic disease
by: Almughem, Fahad
Published: (2018)

Effect of polymer topology on non-covalent polymer-protein complexation: miktoarm versus linear mPEG-poly(glutamic acid) copolymers
by: Nieto-Orellana, Alejandro, et al.
Published: (2017)

Amphiphilic block copolymers from a renewable Ɛ-decalactone monomer: prediction and characterization of micellar core effects on drug encapsulation and release
by: Kakde, Deepak, et al.
Published: (2016)

Screening of the factors for novel pour point depressant copolymer synthesis to improve the copolymer yield
by: B S, Elarbe, et al.
Published: (2019)

Insight into the relationship between the cell culture model, cell trafficking and siRNA silencing efficiency
by: Capel, Victoria, et al.
Published: (2016)

Time and cell-dependent effects of endocytosis inhibitors on the internalization of biomolecule markers and nanomaterials
by: Sasso, Luana, et al.
Published: (2018)

Effects of Copolymers on the Properties of Polysulfone Membranes
by: Boey, Ying Rui
Published: (2019)

Rapid formulation of redox-responsive oligo-β-aminoester polyplexes with siRNA via jet printing
by: Lovato, Tatiana, et al.
Published: (2018)

Synthesis of hydroxylated polyisoprene-graft-polylactide copolymer
by: Neoh, Benjamin Di-Shen, et al.
Published: (2020)

The effect of a copolymer inhibitor on baryte precipitation
by: Ruiz-Agudo, C., et al.
Published: (2014)

Studies on electrochemically synthesized polyaniline and its copolymers
by: Parsa, Ali
Published: (2009)

siRNA blocking of mammalian target of rapamycin (mTOR) attenuates pathology in annonacin-induced tauopathy in mice
by: Salama, Mohamed M., et al.
Published: (2019)

Effects of CXCR4 Silencing by Sirna Engrafted Cotionized Dextran in Mouse Models of Colorectal Cancer and Liver Metastasis
by: Abedini, Fatemeh
Published: (2011)

Cation exchange membranes by radiation-induced graft copolymerization of styrene onto PFA copolymer films. I. preparation and characterization of the graft copolymer
by: Mohamed Mahmoud, Nasef, et al.
Published: (1999)

Phosphorylcholine-based copolymer as synthetic vector for gene delivery
by: Lam, Jenny Ka-Wing
Published: (2006)

Synthesis of nanostructured block copolymer in supercritical carbon dioxide
by: Alauhdin, Mohammad
Published: (2017)

Self-assembly in casting solutions of block copolymer membranes
by: Marques, D., et al.
Published: (2013)

The Influence of Temperature and Drug Concentrations Prednisolone in NIPAAm Copolymer
by: Setiyorini, Y., et al.
Published: (2012)

Natural rubber graft copolymer synthesis - a review
by: Wan Abdul Rahman , Wan Aizan
Published: (1992)

Cation exchange membranes by radiation-induced graft copolymerization of styrene onto PFA copolymer films. II. Charactarization of sulfonated graft copolymer membranes
by: Nasef, Mohamed Mahmoud, et al.
Published: (2000)

Synthesis of Crosslinked Block Copolymer Microparticles in Supercritical CO2
by: Kartini, Alias
Published: (2023)

Topology and shape control for assemblies of block copolymer blends in solution
by: Moreno, N., et al.
Published: (2015)

Surface immobilisation of antibody on cyclic olefin copolymer for sandwich immunoassay
by: Raj, J., et al.
Published: (2009)

UCST-driven self-assembly and crosslinking of diblock copolymer micelles
by: Roth, P., et al.
Published: (2012)