Peripheral killer cells do not differentiate between asthma patients with or without fixed airway obstruction
Objective: The three main types of killer cells – CD8+ T cells, NK cells and NKT cells – have been linked to asthma and chronic obstructive pulmonary disease (COPD). However, their role in a small subset of asthma patients displaying fixed airway obstruction (FAO), similar to that seen in COPD, has...
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| Format: | Article |
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Taylor & Francis
2016
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| Online Access: | https://eprints.nottingham.ac.uk/39043/ |
| _version_ | 1848795749888819200 |
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| author | Tubby, Carolyn Negm, Ola H. Harrison, Timothy W. Tighe, Patrick J. Todd, Ian Fairclough, Lucy C. |
| author_facet | Tubby, Carolyn Negm, Ola H. Harrison, Timothy W. Tighe, Patrick J. Todd, Ian Fairclough, Lucy C. |
| author_sort | Tubby, Carolyn |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Objective: The three main types of killer cells – CD8+ T cells, NK cells and NKT cells – have been linked to asthma and chronic obstructive pulmonary disease (COPD). However, their role in a small subset of asthma patients displaying fixed airway obstruction (FAO), similar to that seen in COPD, has not been explored. The objective of the present study was to investigate killer cell numbers, phenotype and function in peripheral blood from asthma patients with FAO, asthma patients without FAO, and healthy individuals.
Methods: Peripheral CD8+ T cells (CD8+CD3+CD56−), NK cells (CD56+CD3−) and NKT-like cells (CD56+CD3+) of 14 asthma patients with FAO (post-bronchodilator FEV/FVC <0.7, despite clinician-optimised treatment), 7 asthma patients without FAO (post-bronchodilator FEV/FVC ≥0.7), and 9 healthy individuals were studied.
Results: No significant differences were seen between the number, receptor expression, MAPK signalling molecule expression, cytotoxic mediator expression, and functional cytotoxicity of peripheral killer cells from asthma patients with FAO, asthma patients without FAO and healthy individuals.
Conclusions: Peripheral killer cell numbers or functions do not differentiate between asthma patients with or without fixed airway obstruction. |
| first_indexed | 2025-11-14T19:37:02Z |
| format | Article |
| id | nottingham-39043 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:37:02Z |
| publishDate | 2016 |
| publisher | Taylor & Francis |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-390432024-08-15T15:20:36Z https://eprints.nottingham.ac.uk/39043/ Peripheral killer cells do not differentiate between asthma patients with or without fixed airway obstruction Tubby, Carolyn Negm, Ola H. Harrison, Timothy W. Tighe, Patrick J. Todd, Ian Fairclough, Lucy C. Objective: The three main types of killer cells – CD8+ T cells, NK cells and NKT cells – have been linked to asthma and chronic obstructive pulmonary disease (COPD). However, their role in a small subset of asthma patients displaying fixed airway obstruction (FAO), similar to that seen in COPD, has not been explored. The objective of the present study was to investigate killer cell numbers, phenotype and function in peripheral blood from asthma patients with FAO, asthma patients without FAO, and healthy individuals. Methods: Peripheral CD8+ T cells (CD8+CD3+CD56−), NK cells (CD56+CD3−) and NKT-like cells (CD56+CD3+) of 14 asthma patients with FAO (post-bronchodilator FEV/FVC <0.7, despite clinician-optimised treatment), 7 asthma patients without FAO (post-bronchodilator FEV/FVC ≥0.7), and 9 healthy individuals were studied. Results: No significant differences were seen between the number, receptor expression, MAPK signalling molecule expression, cytotoxic mediator expression, and functional cytotoxicity of peripheral killer cells from asthma patients with FAO, asthma patients without FAO and healthy individuals. Conclusions: Peripheral killer cell numbers or functions do not differentiate between asthma patients with or without fixed airway obstruction. Taylor & Francis 2016-10-13 Article PeerReviewed Tubby, Carolyn, Negm, Ola H., Harrison, Timothy W., Tighe, Patrick J., Todd, Ian and Fairclough, Lucy C. (2016) Peripheral killer cells do not differentiate between asthma patients with or without fixed airway obstruction. Journal of Asthma . ISSN 1532-4303 CD8+ T cells; fixed airflow obstruction; natural killer cells; natural killer T cells; protein lysate microarray; asthma http://www.tandfonline.com/doi/full/10.1080/02770903.2016.1236941 doi:10.1080/02770903.2016.1236941 doi:10.1080/02770903.2016.1236941 |
| spellingShingle | CD8+ T cells; fixed airflow obstruction; natural killer cells; natural killer T cells; protein lysate microarray; asthma Tubby, Carolyn Negm, Ola H. Harrison, Timothy W. Tighe, Patrick J. Todd, Ian Fairclough, Lucy C. Peripheral killer cells do not differentiate between asthma patients with or without fixed airway obstruction |
| title | Peripheral killer cells do not differentiate between asthma patients with or without fixed airway obstruction |
| title_full | Peripheral killer cells do not differentiate between asthma patients with or without fixed airway obstruction |
| title_fullStr | Peripheral killer cells do not differentiate between asthma patients with or without fixed airway obstruction |
| title_full_unstemmed | Peripheral killer cells do not differentiate between asthma patients with or without fixed airway obstruction |
| title_short | Peripheral killer cells do not differentiate between asthma patients with or without fixed airway obstruction |
| title_sort | peripheral killer cells do not differentiate between asthma patients with or without fixed airway obstruction |
| topic | CD8+ T cells; fixed airflow obstruction; natural killer cells; natural killer T cells; protein lysate microarray; asthma |
| url | https://eprints.nottingham.ac.uk/39043/ https://eprints.nottingham.ac.uk/39043/ https://eprints.nottingham.ac.uk/39043/ |