Amphiphilic block copolymers from a renewable Ɛ-decalactone monomer: prediction and characterization of micellar core effects on drug encapsulation and release

QR Code

Amphiphilic block copolymers from a renewable Ɛ-decalactone monomer: prediction and characterization of micellar core effects on drug encapsulation and release

Here we describe a methoxy poly(ethyleneglycol)-b-poly(ε-decalactone) (mPEG-b-PεDL) copolymer and investigate the potential of the copolymer as a vehicle for solubilisation and sustained release of indomethacin (IND). The indomethacin loading and release from mPEG-b-PεDL micelles (amorphous cores) w...

Full description

Bibliographic Details
Main Authors:	Kakde, Deepak, Taresco, Vincenzo, Bansal, Kuldeep Kumar, Magennis, E. Peter, Howdle, Steven M., Mantovani, Giuseppe, Irvine, Derek J., Alexander, Cameron
Format:	Article
Published:	Royal Society of Chemistry 2016
Online Access:	https://eprints.nottingham.ac.uk/39006/

Similar Items

New biomaterials from renewable resources – amphiphilic block copolymers from δ-decalactone
by: Bansal, Kuldeep K., et al.
Published: (2015)

Synthesis, characterization and evaluation of in vitro toxicity in hepatocytes of linear polyesters with varied aromatic and aliphatic co-monomers
by: Kakde, Deepak, et al.
Published: (2016)

Novel amphiphilic polymers from renewable feedstock: synthesis, characterisation and applications
by: Bansal, Kuldeep Kumar
Published: (2015)

Novel biotinylated bile acid amphiphiles: Micellar aggregates formation and interaction with hepatocytes
by: Rizzi, L., et al.
Published: (2011)

Liposomes as amphiphilic carriers: encapsulation and stability aspects
by: Sumaira Naeem,, et al.
Published: (2016)

Towards sustainable polymeric nano-carriers and surfactants: facile low temperature enzymatic synthesis of bio-based amphiphilic copolymers in scCO2
by: Curia, Silvio, et al.
Published: (2016)

Development of functional micelles from biodegradable amphiphilic block copolymers for drug delivery and tumour therapy
by: Gulfam, Muhammad
Published: (2017)

Physicochemical studies of triazolyl benzoate amphiphile and the effects of different glycolipids towards its critical micellar concentration / Nurul Faiezin Zul
by: Nurul Faiezin , Zul
Published: (2021)

Synthesis of random and block copolymers from terpene-based and acrylate-based monomers
by: Jordan, Beth
Published: (2022)

Multifunctional poly[N-(2-hydroxypropyl)methacrylamide] copolymers via postpolymerization modification and sequential thiol–ene chemistry
by: Francini, Nora, et al.
Published: (2015)

Effects of photo-initiation and monomer composition onto performance of graft-copolymer based membrane adsorbers
by: Mohd Yusof, Abdul Halim, et al.
Published: (2006)

Synthesis, characterisation and applications of new polyesters for drug delivery
by: Kakde, Deepak
Published: (2016)

Properties of acyl modified poly(glycerol-adipate) comb-like polymers and their self-assembly into nanoparticles
by: Taresco, Vincenzo, et al.
Published: (2016)

RAFT synthesis and stimulus-induced self-assembly in water of copolymers based on the biocompatible monomer 2-(Methacryloyloxy)ethyl phosphorylcholine
by: Yu, B., et al.
Published: (2009)

Variation in structure and properties of poly(glycerol adipate) via control of chain branching during enzymatic synthesis
by: Taresco, Vincenzo, et al.
Published: (2016)

The Functionalisation of Terpenes Towards Amphiphilic Materials
by: Fowler, Harriet
Published: (2024)

Amphiphilic nanocomposite proton conducting membrane
by: Hamdan, Halimaton
Published: (2009)

One-pot RAFT and fast polymersomes assembly: a ‘beeline’ from monomers to drug-loaded nanovectors
by: Mastrotto, Francesca, et al.
Published: (2016)

Nano-encapsulated organic phase change material based on copolymer nanocomposites for thermal energy storage
by: Khadiran, Tumirah, et al.
Published: (2014)

One-pot RAFT and fast polymersomes assembly: a ‘beeline’ from monomers to drug-loaded nanovectors
by: Mastrotto, Francesca, et al.
Published: (2016)

Block copolymer synthesis by controlled/living radical polymerisation in heterogeneous systems
by: Jennings, James, et al.
Published: (2016)

A Natural Flavour in an Amphiphilic Association Structure
by: Suhaimi, Hamdan, et al.
Published: (1995)

Triblock copolymer nanovesicles for pH-responsive targeted delivery and controlled release of siRNA to cancer cells
by: Gallon, Elena, et al.
Published: (2015)

Dry-powder formulations of non-covalent protein complexes with linear or miktoarm copolymers for pulmonary delivery
by: Nieto-Orellana, Alejandro, et al.
Published: (2018)

A facile and green route to terpene derived acrylate and methacrylate monomers and simple free radical polymerisation to yield new renewable polymers and coatings
by: Sainz, M.F., et al.
Published: (2016)

Radical grafting of medium chain-length poly-3-hydroxyalkanoates with glycerol 1,3- diglycerolate diacrylate to form amphiphilic gels: Mechanism and copolymer characterization / Syed Mohammad Daniel Syed Mohamed
by: Syed Mohammad Daniel , Syed Mohamed
Published: (2019)

Amphiphile Structures in the Solid State: Complex Cations with Lipophilic Substituents
by: Harrowfield, J., et al.
Published: (2005)

Amphiphilic solid basic catalyst for biodiesel production: Synthesis and characterization
by: Izan Izwan, Misnon, et al.
Published: (2011)

Micropolarity of normal micellar interior associated with the exchange of pentanol
by: Che Rose, Laili, et al.
Published: (1997)

Separation of organophosphorus pesticides using micellar electrokinetic chromatography
by: Monjurul Alam, S. M.
Published: (2005)

Separation of organophosphorus pesticides using micellar electrokinetic chromatography
by: W. Ibrahim, W. Aini, et al.
Published: (2003)

A facile route to bespoke macro- and mesoporous block copolymer microparticles
by: He, Guping, et al.
Published: (2018)

Versatile routes to functional RAFT chain transfer agents through the Passerini multicomponent reaction
by: Pearce, Amanda K., et al.
Published: (2017)

Stimuli-responsive prodrug chemistries for drug delivery
by: Taresco, Vincenzo, et al.
Published: (2018)

Synthesis and properties of new carbosilane copolymers and symmetrical bis(alkoxybenzylidene)- 1,5-naphthalene dimers based on bisphenol schiff base monomers / Wisam Naji Atiyah Al-Mehana
by: Wisam Naji Atiyah, Al-Mehana
Published: (2015)

Thermotropic and lyotropic liquid crystal behaviour of Amphiphilic mannosides / Melonney Patrick
by: Melonney , Patrick
Published: (2018)

Porous amphiphilic biogel from a facile chemo-biosynthetic route
by: Syed Mohamed, Syed Mohammad Daniel, et al.
Published: (2020)

Gemini pyridinium amphiphiles for the synthesis and stabilization of gold nanoparticles for drug delivery
by: Alea-Reyes, Maria E., et al.
Published: (2017)

The Supramolecular Chemistry of Amphiphilic Redox-Active Organic-Inorganic Hybrid Polyoxometalates
by: Amin, Sharad
Published: (2021)

Effect of polymer topology on non-covalent polymer-protein complexation: miktoarm versus linear mPEG-poly(glutamic acid) copolymers
by: Nieto-Orellana, Alejandro, et al.
Published: (2017)