From start to finish: amino-terminal protein modifications as degradation signals in plants
The amino- (N-) terminus (Nt) of a protein can undergo a diverse array of co- and posttranslational modifications. Many of these create degradation signals (N-degrons) that mediate protein destruction via the N-end rule pathway of ubiquitin-mediated proteolysis. In plants, the N-end rule pathway has...
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| Format: | Article |
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Wiley
2016
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| Online Access: | https://eprints.nottingham.ac.uk/38975/ |
| _version_ | 1848795732322025472 |
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| author | Gibbs, Daniel J. Bailey, Mark Tedds, Hannah M. Holdsworth, Michael J. |
| author_facet | Gibbs, Daniel J. Bailey, Mark Tedds, Hannah M. Holdsworth, Michael J. |
| author_sort | Gibbs, Daniel J. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The amino- (N-) terminus (Nt) of a protein can undergo a diverse array of co- and posttranslational modifications. Many of these create degradation signals (N-degrons) that mediate protein destruction via the N-end rule pathway of ubiquitin-mediated proteolysis. In plants, the N-end rule pathway has emerged as a major system for regulated control of protein stability. Nt-arginylation-dependent degradation regulates multiple growth, development and stress responses, and recently identified functions of Nt-acetylation can also be linked to effects on the in vivo half-lives of Nt-acetylated proteins. There is also increasing evidence that N-termini could act as important protein stability determinants in plastids. Here we review recent advances in our understanding of the relationship between the nature of protein N-termini, Nt-processing events and proteolysis in plants. |
| first_indexed | 2025-11-14T19:36:46Z |
| format | Article |
| id | nottingham-38975 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:36:46Z |
| publishDate | 2016 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-389752020-05-04T18:00:08Z https://eprints.nottingham.ac.uk/38975/ From start to finish: amino-terminal protein modifications as degradation signals in plants Gibbs, Daniel J. Bailey, Mark Tedds, Hannah M. Holdsworth, Michael J. The amino- (N-) terminus (Nt) of a protein can undergo a diverse array of co- and posttranslational modifications. Many of these create degradation signals (N-degrons) that mediate protein destruction via the N-end rule pathway of ubiquitin-mediated proteolysis. In plants, the N-end rule pathway has emerged as a major system for regulated control of protein stability. Nt-arginylation-dependent degradation regulates multiple growth, development and stress responses, and recently identified functions of Nt-acetylation can also be linked to effects on the in vivo half-lives of Nt-acetylated proteins. There is also increasing evidence that N-termini could act as important protein stability determinants in plastids. Here we review recent advances in our understanding of the relationship between the nature of protein N-termini, Nt-processing events and proteolysis in plants. Wiley 2016-07-21 Article PeerReviewed Gibbs, Daniel J., Bailey, Mark, Tedds, Hannah M. and Holdsworth, Michael J. (2016) From start to finish: amino-terminal protein modifications as degradation signals in plants. New Phytologist, 211 (4). pp. 1188-1194. ISSN 1469-8137 N-terminus proteolysis N-end rule N-degron protein modification Nt-12 acetylation protease ubiquitin proteasome system http://onlinelibrary.wiley.com/doi/10.1111/nph.14105/full doi:10.1111/nph.14105 doi:10.1111/nph.14105 |
| spellingShingle | N-terminus proteolysis N-end rule N-degron protein modification Nt-12 acetylation protease ubiquitin proteasome system Gibbs, Daniel J. Bailey, Mark Tedds, Hannah M. Holdsworth, Michael J. From start to finish: amino-terminal protein modifications as degradation signals in plants |
| title | From start to finish: amino-terminal protein modifications as degradation signals in plants |
| title_full | From start to finish: amino-terminal protein modifications as degradation signals in plants |
| title_fullStr | From start to finish: amino-terminal protein modifications as degradation signals in plants |
| title_full_unstemmed | From start to finish: amino-terminal protein modifications as degradation signals in plants |
| title_short | From start to finish: amino-terminal protein modifications as degradation signals in plants |
| title_sort | from start to finish: amino-terminal protein modifications as degradation signals in plants |
| topic | N-terminus proteolysis N-end rule N-degron protein modification Nt-12 acetylation protease ubiquitin proteasome system |
| url | https://eprints.nottingham.ac.uk/38975/ https://eprints.nottingham.ac.uk/38975/ https://eprints.nottingham.ac.uk/38975/ |