Plasma lipid biomarker signatures in squamous carcinoma and adenocarcinoma lung cancer patients
There is a clinical need for reliable biomarkers for lung cancer that permit early diagnosis of the disease and provide prediction of histological phenotype. A prospective study design was used with a study population of patients with suspected lung cancer. Blood samples were collected from 17 patie...
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Springer
2015
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| Online Access: | https://eprints.nottingham.ac.uk/38882/ |
| _version_ | 1848795711892619264 |
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| author | Ravipati, Srinivasarao Baldwin, David R. Barr, Helen L. Fogarty, Andrew W. Barrett, David A. |
| author_facet | Ravipati, Srinivasarao Baldwin, David R. Barr, Helen L. Fogarty, Andrew W. Barrett, David A. |
| author_sort | Ravipati, Srinivasarao |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | There is a clinical need for reliable biomarkers for lung cancer that permit early diagnosis of the disease and provide prediction of histological phenotype. A prospective study design was used with a study population of patients with suspected lung cancer. Blood samples were collected from 17 patients with histologically confirmed squamous cell lung carcinoma, 17 individuals with adenocarcinoma, and 17 control individuals who did not subsequently have a diagnosis of lung cancer or any other cancer. Blood plasma samples were analysed for their lipid profiles using liquid chromatography coupled with high resolution mass spectrometry. Data were analysed using multivariate statistical methods. There was good separation between histological subtypes and control groups and also between individuals with a subsequent diagnosis of adenocarcinoma and squamous cell carcinoma (sensitivity 80 %, specificity 83 %, Q2 = 0.70). Alterations in the levels of different classes of lipids including triglycerides (TGs), phosphatidylinositols (PIs), phosphatidylcholines (PCs), phosphatidylethanolamines (PEs), free fatty acids, lysophospholipids and sphingolipids were observed in squamous carcinoma and adenocarcinoma lung cancer patients when compared with control patients. In conclusion, this study has identified candidate lipid biomarkers of non-small cell lung cancer patients which may be helpful to indicate the tumour subtype and to differentiate them from patients who do not have lung cancer. Measuring these biomarkers has the potential to improve diagnosis in patients with suspected lung cancer and risk stratification in screening. |
| first_indexed | 2025-11-14T19:36:26Z |
| format | Article |
| id | nottingham-38882 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:36:26Z |
| publishDate | 2015 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-388822020-05-04T17:08:03Z https://eprints.nottingham.ac.uk/38882/ Plasma lipid biomarker signatures in squamous carcinoma and adenocarcinoma lung cancer patients Ravipati, Srinivasarao Baldwin, David R. Barr, Helen L. Fogarty, Andrew W. Barrett, David A. There is a clinical need for reliable biomarkers for lung cancer that permit early diagnosis of the disease and provide prediction of histological phenotype. A prospective study design was used with a study population of patients with suspected lung cancer. Blood samples were collected from 17 patients with histologically confirmed squamous cell lung carcinoma, 17 individuals with adenocarcinoma, and 17 control individuals who did not subsequently have a diagnosis of lung cancer or any other cancer. Blood plasma samples were analysed for their lipid profiles using liquid chromatography coupled with high resolution mass spectrometry. Data were analysed using multivariate statistical methods. There was good separation between histological subtypes and control groups and also between individuals with a subsequent diagnosis of adenocarcinoma and squamous cell carcinoma (sensitivity 80 %, specificity 83 %, Q2 = 0.70). Alterations in the levels of different classes of lipids including triglycerides (TGs), phosphatidylinositols (PIs), phosphatidylcholines (PCs), phosphatidylethanolamines (PEs), free fatty acids, lysophospholipids and sphingolipids were observed in squamous carcinoma and adenocarcinoma lung cancer patients when compared with control patients. In conclusion, this study has identified candidate lipid biomarkers of non-small cell lung cancer patients which may be helpful to indicate the tumour subtype and to differentiate them from patients who do not have lung cancer. Measuring these biomarkers has the potential to improve diagnosis in patients with suspected lung cancer and risk stratification in screening. Springer 2015-05-26 Article PeerReviewed Ravipati, Srinivasarao, Baldwin, David R., Barr, Helen L., Fogarty, Andrew W. and Barrett, David A. (2015) Plasma lipid biomarker signatures in squamous carcinoma and adenocarcinoma lung cancer patients. Metabolomics, 11 (6). pp. 1600-1611. ISSN 1573-3890 lung cancer squamous carcinoma adenocarcinoma lipidomics http://link.springer.com/article/10.1007%2Fs11306-015-0811-x doi:10.1007/s11306-015-0811-x doi:10.1007/s11306-015-0811-x |
| spellingShingle | lung cancer squamous carcinoma adenocarcinoma lipidomics Ravipati, Srinivasarao Baldwin, David R. Barr, Helen L. Fogarty, Andrew W. Barrett, David A. Plasma lipid biomarker signatures in squamous carcinoma and adenocarcinoma lung cancer patients |
| title | Plasma lipid biomarker signatures in squamous carcinoma and adenocarcinoma lung cancer patients |
| title_full | Plasma lipid biomarker signatures in squamous carcinoma and adenocarcinoma lung cancer patients |
| title_fullStr | Plasma lipid biomarker signatures in squamous carcinoma and adenocarcinoma lung cancer patients |
| title_full_unstemmed | Plasma lipid biomarker signatures in squamous carcinoma and adenocarcinoma lung cancer patients |
| title_short | Plasma lipid biomarker signatures in squamous carcinoma and adenocarcinoma lung cancer patients |
| title_sort | plasma lipid biomarker signatures in squamous carcinoma and adenocarcinoma lung cancer patients |
| topic | lung cancer squamous carcinoma adenocarcinoma lipidomics |
| url | https://eprints.nottingham.ac.uk/38882/ https://eprints.nottingham.ac.uk/38882/ https://eprints.nottingham.ac.uk/38882/ |