Exploring block and permeation of N-methyl-D-Aspartate (NMDA) receptor channels for treatment of neurodegenerative disorders

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Exploring block and permeation of N-methyl-D-Aspartate (NMDA) receptor channels for treatment of neurodegenerative disorders

N-methyl-D-aspartate receptors (NMDAR) are ionotropic glutamate receptors which can be blocked by Mg2+ in a voltage-dependent manner and are highly permeable to Ca2+, hence they represent a medically relevant target for neurodegenerative disorders caused by excitotoxicity. The two main objectives of...

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Bibliographic Details
Main Author:	Abu, Izuddin Fahmy
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2016
Subjects:	Methyl aspartate receptors Alzheimer's disease NMDAR blocker Neuroprotection
Online Access:	https://eprints.nottingham.ac.uk/38591/

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