Healthy ageing of cloned sheep
The health of cloned animals generated by somatic-cell nuclear transfer (SCNT) has been of concern since its inception; however, there are no detailed assessments of late-onset, non-communicable diseases. Here we report that SCNT has no obvious detrimental longterm health effects in a cohort of 13 c...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
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Nature Publishing Group
2016
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| Online Access: | https://eprints.nottingham.ac.uk/38462/ |
| _version_ | 1848795617437941760 |
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| author | Sinclair, Kevin D. Corr, Sandra A. Gutierrez, Carlos G. Fisher, Patricia A. Lee, J.-H. Rathbone, Alexandra J. Choi, Inchul Campbell, Keith H.S. Gardner, David S. |
| author_facet | Sinclair, Kevin D. Corr, Sandra A. Gutierrez, Carlos G. Fisher, Patricia A. Lee, J.-H. Rathbone, Alexandra J. Choi, Inchul Campbell, Keith H.S. Gardner, David S. |
| author_sort | Sinclair, Kevin D. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The health of cloned animals generated by somatic-cell nuclear transfer (SCNT) has been of concern since its inception; however, there are no detailed assessments of late-onset, non-communicable diseases. Here we report that SCNT has no obvious detrimental longterm health effects in a cohort of 13 cloned sheep. We perform musculoskeletal assessments, metabolic tests and blood pressure measurements in 13 aged (7–9 years old) cloned sheep, including four derived from the cell line that gave rise to Dolly. We also perform radiological examinations of all main joints, including the knees, the joint most affected by osteoarthritis in Dolly, and compare all health parameters to groups of 5- and 6-year-old sheep, and published reference ranges. Despite their advanced age, these clones are euglycaemic, insulin sensitive and normotensive. Importantly, we observe no clinical signs of degenerative joint disease apart from mild, or in one case moderate, osteoarthritis in some animals. Our study is the first to assess the long-term health outcomes of SCNT in large animals. |
| first_indexed | 2025-11-14T19:34:56Z |
| format | Article |
| id | nottingham-38462 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:34:56Z |
| publishDate | 2016 |
| publisher | Nature Publishing Group |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-384622020-05-04T17:59:43Z https://eprints.nottingham.ac.uk/38462/ Healthy ageing of cloned sheep Sinclair, Kevin D. Corr, Sandra A. Gutierrez, Carlos G. Fisher, Patricia A. Lee, J.-H. Rathbone, Alexandra J. Choi, Inchul Campbell, Keith H.S. Gardner, David S. The health of cloned animals generated by somatic-cell nuclear transfer (SCNT) has been of concern since its inception; however, there are no detailed assessments of late-onset, non-communicable diseases. Here we report that SCNT has no obvious detrimental longterm health effects in a cohort of 13 cloned sheep. We perform musculoskeletal assessments, metabolic tests and blood pressure measurements in 13 aged (7–9 years old) cloned sheep, including four derived from the cell line that gave rise to Dolly. We also perform radiological examinations of all main joints, including the knees, the joint most affected by osteoarthritis in Dolly, and compare all health parameters to groups of 5- and 6-year-old sheep, and published reference ranges. Despite their advanced age, these clones are euglycaemic, insulin sensitive and normotensive. Importantly, we observe no clinical signs of degenerative joint disease apart from mild, or in one case moderate, osteoarthritis in some animals. Our study is the first to assess the long-term health outcomes of SCNT in large animals. Nature Publishing Group 2016-07-26 Article PeerReviewed Sinclair, Kevin D., Corr, Sandra A., Gutierrez, Carlos G., Fisher, Patricia A., Lee, J.-H., Rathbone, Alexandra J., Choi, Inchul, Campbell, Keith H.S. and Gardner, David S. (2016) Healthy ageing of cloned sheep. Nature Communications, 7 . 12359/1-12369/10. ISSN 2041-1723 http://www.nature.com/articles/ncomms12359 doi:10.1038/ncomms12359 doi:10.1038/ncomms12359 |
| spellingShingle | Sinclair, Kevin D. Corr, Sandra A. Gutierrez, Carlos G. Fisher, Patricia A. Lee, J.-H. Rathbone, Alexandra J. Choi, Inchul Campbell, Keith H.S. Gardner, David S. Healthy ageing of cloned sheep |
| title | Healthy ageing of cloned sheep |
| title_full | Healthy ageing of cloned sheep |
| title_fullStr | Healthy ageing of cloned sheep |
| title_full_unstemmed | Healthy ageing of cloned sheep |
| title_short | Healthy ageing of cloned sheep |
| title_sort | healthy ageing of cloned sheep |
| url | https://eprints.nottingham.ac.uk/38462/ https://eprints.nottingham.ac.uk/38462/ https://eprints.nottingham.ac.uk/38462/ |