Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort
U-BIOPRED is a European Union consortium of 20 academic institutions, 11 pharmaceutical companies and six patient organisations with the objective of improving the understanding of asthma disease mechanisms using a systems biology approach. This cross-sectional assessment of adults with severe as...
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| Format: | Article |
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European Respiratory Society
2015
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| Online Access: | https://eprints.nottingham.ac.uk/38425/ |
| _version_ | 1848795608309039104 |
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| author | Shaw, Dominick E. Sousa, Ana R. Fowler, Stephen J. Fleming, Louise J. Roberts, Graham Corfield, Julie Pandis, Ioannis Bansal, Aruna T. Bel, Elisabeth H. Auffray, Charles Compton, Chris H. Bisgaard, Hans Bucchioni, Enrica Caruso, Massimo Chanez, Pascal Dahlen, Barbro Dahlen, Sven-Erik Dyson, Kerry Frey, Urs Geiser, Thomas Gerhardsson de Verdier, Maria Gibeon, David Guo, Yi-ke Hashimoto, Simone Hedlin, Gunilla Jeyasingham, Elizabeth Hekking, Pieter-Paul W. Higenbottam, Tim Horváth, Ildikó Knox, Alan J. Krug, Norbert Erpenbeck, Veit J. Larsson, Lars X. Lazarinis, Nikos Matthews, John G. Middelveld, Roelinde Montuschi, Paolo Musial, Jacek Myles, David Pahus, Laurie Sandström, Thomas Seibold, Wolfgang Singer, Florian Strandberg, Karin Vestbo, Jorgen Vissing, Nadja von Garnier, Christophe Adcock, Ian M. Wagers, Scott Rowe, Anthony Howarth, Peter Wagener, Ariane H. Djukanovic, Ratko Sterk, Peter J. Chung, Kian Fan |
| author_facet | Shaw, Dominick E. Sousa, Ana R. Fowler, Stephen J. Fleming, Louise J. Roberts, Graham Corfield, Julie Pandis, Ioannis Bansal, Aruna T. Bel, Elisabeth H. Auffray, Charles Compton, Chris H. Bisgaard, Hans Bucchioni, Enrica Caruso, Massimo Chanez, Pascal Dahlen, Barbro Dahlen, Sven-Erik Dyson, Kerry Frey, Urs Geiser, Thomas Gerhardsson de Verdier, Maria Gibeon, David Guo, Yi-ke Hashimoto, Simone Hedlin, Gunilla Jeyasingham, Elizabeth Hekking, Pieter-Paul W. Higenbottam, Tim Horváth, Ildikó Knox, Alan J. Krug, Norbert Erpenbeck, Veit J. Larsson, Lars X. Lazarinis, Nikos Matthews, John G. Middelveld, Roelinde Montuschi, Paolo Musial, Jacek Myles, David Pahus, Laurie Sandström, Thomas Seibold, Wolfgang Singer, Florian Strandberg, Karin Vestbo, Jorgen Vissing, Nadja von Garnier, Christophe Adcock, Ian M. Wagers, Scott Rowe, Anthony Howarth, Peter Wagener, Ariane H. Djukanovic, Ratko Sterk, Peter J. Chung, Kian Fan |
| author_sort | Shaw, Dominick E. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | U-BIOPRED is a European Union consortium of 20 academic institutions, 11 pharmaceutical companies and six patient organisations with the objective of improving the understanding of asthma disease mechanisms using a systems biology approach.
This cross-sectional assessment of adults with severe asthma, mild/moderate asthma and healthy controls from 11 European countries consisted of analyses of patient-reported outcomes, lung function, blood and airway inflammatory measurements.
Patients with severe asthma (nonsmokers, n=311; smokers/ex-smokers, n=110) had more symptoms and exacerbations compared to patients with mild/moderate disease (n=88) (2.5 exacerbations versus 0.4 in the preceding 12 months; p<0.001), with worse quality of life, and higher levels of anxiety and depression. They also had a higher incidence of nasal polyps and gastro-oesophageal reflux with lower lung function. Sputum eosinophil count was higher in severe asthma compared to mild/moderate asthma (median count 2.99% versus 1.05%; p=0.004) despite treatment with higher doses of inhaled and/or oral corticosteroids.
Consistent with other severe asthma cohorts, U-BIOPRED is characterised by poor symptom control, increased comorbidity and airway inflammation, despite high levels of treatment. It is well suited to identify asthma phenotypes using the array of “omic” datasets that are at the core of this systems medicine approach. |
| first_indexed | 2025-11-14T19:34:47Z |
| format | Article |
| id | nottingham-38425 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:34:47Z |
| publishDate | 2015 |
| publisher | European Respiratory Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-384252024-08-15T15:17:32Z https://eprints.nottingham.ac.uk/38425/ Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort Shaw, Dominick E. Sousa, Ana R. Fowler, Stephen J. Fleming, Louise J. Roberts, Graham Corfield, Julie Pandis, Ioannis Bansal, Aruna T. Bel, Elisabeth H. Auffray, Charles Compton, Chris H. Bisgaard, Hans Bucchioni, Enrica Caruso, Massimo Chanez, Pascal Dahlen, Barbro Dahlen, Sven-Erik Dyson, Kerry Frey, Urs Geiser, Thomas Gerhardsson de Verdier, Maria Gibeon, David Guo, Yi-ke Hashimoto, Simone Hedlin, Gunilla Jeyasingham, Elizabeth Hekking, Pieter-Paul W. Higenbottam, Tim Horváth, Ildikó Knox, Alan J. Krug, Norbert Erpenbeck, Veit J. Larsson, Lars X. Lazarinis, Nikos Matthews, John G. Middelveld, Roelinde Montuschi, Paolo Musial, Jacek Myles, David Pahus, Laurie Sandström, Thomas Seibold, Wolfgang Singer, Florian Strandberg, Karin Vestbo, Jorgen Vissing, Nadja von Garnier, Christophe Adcock, Ian M. Wagers, Scott Rowe, Anthony Howarth, Peter Wagener, Ariane H. Djukanovic, Ratko Sterk, Peter J. Chung, Kian Fan U-BIOPRED is a European Union consortium of 20 academic institutions, 11 pharmaceutical companies and six patient organisations with the objective of improving the understanding of asthma disease mechanisms using a systems biology approach. This cross-sectional assessment of adults with severe asthma, mild/moderate asthma and healthy controls from 11 European countries consisted of analyses of patient-reported outcomes, lung function, blood and airway inflammatory measurements. Patients with severe asthma (nonsmokers, n=311; smokers/ex-smokers, n=110) had more symptoms and exacerbations compared to patients with mild/moderate disease (n=88) (2.5 exacerbations versus 0.4 in the preceding 12 months; p<0.001), with worse quality of life, and higher levels of anxiety and depression. They also had a higher incidence of nasal polyps and gastro-oesophageal reflux with lower lung function. Sputum eosinophil count was higher in severe asthma compared to mild/moderate asthma (median count 2.99% versus 1.05%; p=0.004) despite treatment with higher doses of inhaled and/or oral corticosteroids. Consistent with other severe asthma cohorts, U-BIOPRED is characterised by poor symptom control, increased comorbidity and airway inflammation, despite high levels of treatment. It is well suited to identify asthma phenotypes using the array of “omic” datasets that are at the core of this systems medicine approach. European Respiratory Society 2015-11-01 Article PeerReviewed Shaw, Dominick E., Sousa, Ana R., Fowler, Stephen J., Fleming, Louise J., Roberts, Graham, Corfield, Julie, Pandis, Ioannis, Bansal, Aruna T., Bel, Elisabeth H., Auffray, Charles, Compton, Chris H., Bisgaard, Hans, Bucchioni, Enrica, Caruso, Massimo, Chanez, Pascal, Dahlen, Barbro, Dahlen, Sven-Erik, Dyson, Kerry, Frey, Urs, Geiser, Thomas, Gerhardsson de Verdier, Maria, Gibeon, David, Guo, Yi-ke, Hashimoto, Simone, Hedlin, Gunilla, Jeyasingham, Elizabeth, Hekking, Pieter-Paul W., Higenbottam, Tim, Horváth, Ildikó, Knox, Alan J., Krug, Norbert, Erpenbeck, Veit J., Larsson, Lars X., Lazarinis, Nikos, Matthews, John G., Middelveld, Roelinde, Montuschi, Paolo, Musial, Jacek, Myles, David, Pahus, Laurie, Sandström, Thomas, Seibold, Wolfgang, Singer, Florian, Strandberg, Karin, Vestbo, Jorgen, Vissing, Nadja, von Garnier, Christophe, Adcock, Ian M., Wagers, Scott, Rowe, Anthony, Howarth, Peter, Wagener, Ariane H., Djukanovic, Ratko, Sterk, Peter J. and Chung, Kian Fan (2015) Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort. European Respiratory Journal, 46 (5). pp. 1308-1321. ISSN 1399-3003 http://erj.ersjournals.com/content/46/5/1308 doi:10.1183/13993003.00779-2015 doi:10.1183/13993003.00779-2015 |
| spellingShingle | Shaw, Dominick E. Sousa, Ana R. Fowler, Stephen J. Fleming, Louise J. Roberts, Graham Corfield, Julie Pandis, Ioannis Bansal, Aruna T. Bel, Elisabeth H. Auffray, Charles Compton, Chris H. Bisgaard, Hans Bucchioni, Enrica Caruso, Massimo Chanez, Pascal Dahlen, Barbro Dahlen, Sven-Erik Dyson, Kerry Frey, Urs Geiser, Thomas Gerhardsson de Verdier, Maria Gibeon, David Guo, Yi-ke Hashimoto, Simone Hedlin, Gunilla Jeyasingham, Elizabeth Hekking, Pieter-Paul W. Higenbottam, Tim Horváth, Ildikó Knox, Alan J. Krug, Norbert Erpenbeck, Veit J. Larsson, Lars X. Lazarinis, Nikos Matthews, John G. Middelveld, Roelinde Montuschi, Paolo Musial, Jacek Myles, David Pahus, Laurie Sandström, Thomas Seibold, Wolfgang Singer, Florian Strandberg, Karin Vestbo, Jorgen Vissing, Nadja von Garnier, Christophe Adcock, Ian M. Wagers, Scott Rowe, Anthony Howarth, Peter Wagener, Ariane H. Djukanovic, Ratko Sterk, Peter J. Chung, Kian Fan Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort |
| title | Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort |
| title_full | Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort |
| title_fullStr | Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort |
| title_full_unstemmed | Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort |
| title_short | Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort |
| title_sort | clinical and inflammatory characteristics of the european u-biopred adult severe asthma cohort |
| url | https://eprints.nottingham.ac.uk/38425/ https://eprints.nottingham.ac.uk/38425/ https://eprints.nottingham.ac.uk/38425/ |