Investigating splicing variants uncovered by next-generation sequencing the Alzheimer’s disease candidate genes, CLU, PICALM, CR1, ABCA7, BIN1, the MS4A locus, CD2AP, EPHA1 and CD33

QR Code

Investigating splicing variants uncovered by next-generation sequencing the Alzheimer’s disease candidate genes, CLU, PICALM, CR1, ABCA7, BIN1, the MS4A locus, CD2AP, EPHA1 and CD33

Late onset Alzheimer’s disease (LOAD), the most common cause of late onset dementia, has a strong genetic component. To date, 21 disease-risk loci have been identified through genome wide association studies (GWAS). However, the causative functional variant(s) within these loci are yet to be discove...

Full description

Bibliographic Details
Main Authors:	Clement, Naomi, Braae, Anne, Turton, James, Lord, Jenny, Guetta-Baranes, Tamar, Medway, Christopher, Brookes, Keeley, Barber, Imelda S., Patel, Tulsi, Milla, Lucy, Azzopardi, Maria, Lowe, James, Mann, David, Pickering-Brown, Stuart, Kalsheker, Noor, Passmore, Peter, Chappell, Sally, Morgan, Kevin
Format:	Article
Published:	OMICS International 2016
Subjects:	Late onset Alzheimer’s disease; Next generation sequencing; Splicing; Annotation; Functional variations; Minigene assays
Online Access:	https://eprints.nottingham.ac.uk/38399/

Similar Items

Next generation sequencing of CLU, PICALM and CR1: pitfalls and potential solutions
by: Lord, Jenny, et al.
Published: (2012)

Investigating the role of CLU PICALM and CR1 in Alzheimer's disease
by: Lord, Jenny
Published: (2014)

Exploring potential functional variants in the Alzheimer’s disease associated genes, CD2AP, EPHA1 and CD33
by: Braae, Anne
Published: (2016)

Correlation of clinical and molecular features in myotonic dystrophy type 1 (DM1)
by: Sedehizadeh, Saam
Published: (2019)

Complement receptor 1 gene (CR1) intragenic duplication and risk of Alzheimer’s disease
by: Kucukkilic, Ezgi, et al.
Published: (2018)

Insecticide resistance mediated 1 by an exon skipping event
by: Berger, Madeleine, et al.
Published: (2016)

Alternative splicing and the inhibition of splicing kinases in Alzheimer’s Disease
by: Alalwany, Roaa
Published: (2021)

Isolation and cloning of ABCA1 gene from Rasbora sarawakensis
by: Kuba, Annie
Published: (2015)

Modulation of IL-10 production by CD3/CD55 induced Type 1 regulatory (Tr1) T-cells
by: Musarrat, Tajkia
Published: (2019)

m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination
by: Haussmann, Irmgard U., et al.
Published: (2016)

An Immunohistochemical Study of CD1a and CD83-Positive Infiltrating Dendritic Cell Density in Cervical Neoplasia
by: Mohammad Zulkarnaen, Ahmad Narihan, et al.
Published: (2007)

The CD1d-natural killer T cell axis in atherosclerosis
by: Bondarenko, S., et al.
Published: (2014)

Characterisation of alternative splice variants of PIP5K1A in the human metastatic prostate cancer cell line, LNCaP C4-2
by: Roberts, Christopher / C.J.
Published: (2022)

The effects of EPHA2 inhibition on VEGF, VEGFR-1 and VEGFR-2 in human malignant glioma cells
by: Baharuddin, Wan Noor Ainun
Published: (2018)

TRAK2, a novel regulator of ABCA1 expression, cholesterol efflux and HDL biogenesis
by: Lake, N., et al.
Published: (2017)

ABCA7 p.G215S as potential protective factor for Alzheimer’s disease
by: Sassi, C., et al.
Published: (2016)

Control of CD nozzle flow using microjets at Mach 2.1
by: Akhtar, Mohammad Nishat, et al.
Published: (2019)

CD148/DEP-1 association with areas of cytoskeletal organisation in macrophages
by: Dave, R., et al.
Published: (2009)

The relationship between miRNA biogenesis and RNA splicing
by: Parsons, Aimee
Published: (2018)

Bond Behaviour of Reinforced Fly Ash-Based Geopolymer Concrete Beams
by: Chang, Ee Hui, et al.
Published: (2009)

CD31 (PECAM-1) is a marker of recent thymic emigrants among CD4+ T-cells, but not CD8+ T-cells or ? d T-cells, in HIV patients responding to ART
by: Tanaskovic, S., et al.
Published: (2010)

A study on the effects of insulin, TNF-Alpha and antioxidants on the expression of ATP-Binding cassette transporter 1 (ABCA1) in HEPG2 cells
by: Hia, Yi Lin
Published: (2015)

ZnxCd1-x (O) Thin Film Nanorods for PV Applications
by: Mohamad, Souad A., et al.
Published: (2013)

ZnxCd1-x (O) thin film nanorods for PV applications
by: Mushtaq, Umer, et al.
Published: (2013)

Generation of endogenous soluble PD-1 as a potential therapeutic strategy for cancer treatment
by: Wahid, Mussarat
Published: (2019)

Whole-exome sequencing of the BDR cohort: evidence to support the role of the PILRA gene in Alzheimer’s disease
by: Patel, Tulsi, et al.
Published: (2017)

CD4-binding site alterations in CCR5-using HIV-1 envelopes influencing gp120-CD4 interactions and fusogenicity
by: Sterjovski, J., et al.
Published: (2011)

A study of inhibition and reversal of plasmodium Falciparum cytoadherence using rna apatamer specific to icam-1 /cd54 and cd36 protein
by: Khairul Mohd, Fadzli Mustaffa
Published: (2018)

A study of inhibition and reversal of plasmodium falciparum cytoadherence using RNA apatamer specific to ICAM-1 /CD54 and CD36 protein
by: Mustaffa, Khairul Mohd Fadzli
Published: (2018)

VEGF-A165b protects against proteinuria in a mouse model with progressive depletion of all endogenous VEGF-A splice isoforms from the kidney
by: Stevens, Megan, et al.
Published: (2017)

Conformational alterations in the CD4 binding cavity of HIV-1 gp120 influencing gp120-CD4 interactions and fusogenicity of HIV-1 envelopes derived from brain and other tissues
by: Gray, L., et al.
Published: (2011)

Prevalence of classical CD14++/CD16 - But not of intermediate CD14++/CD16 + monocytes in hypoalphalipoproteinemia
by: Sala, F., et al.
Published: (2013)

Small molecules which improve pathogenesis of myotonic dystrophy type 1
by: López-Morató, Marta, et al.
Published: (2018)

Elucidating the proportion of CD4+ and CD8+ regulatory t-cells, associated Cytokines, and epstein-barr virus’ LMP1 Xhoi mutation in nasopharyngeal carcinoma
by: Irekeola, Ahmad Adebayo
Published: (2023)

Computer simulations of the interactions of the (0 1 2) and (0 0 1) surfaces of jarosite with Al, Cd, Cu2+ and Zn
by: Hudson-Edwards, K., et al.
Published: (2011)

Electrodeposited CdS/CdTe solar cells
by: Mohamad, Souad A.
Published: (2011)

Structural and optical properties of PVP-capped nanocrystalline ZnxCd1−xS solid solutions
by: Vernosfaderani, Mina Askari, et al.
Published: (2015)

Polygenic risk score in postmortem diagnosed sporadic early-onset Alzheimer’s disease
by: Chaudhary, Sultan, et al.
Published: (2018)

Epha2 sirna silencing on malignant glioma cells
by: Azman , Amy Shafinas
Published: (2017)

Mutation analysis of sporadic early-onset Alzheimer's disease using the NeuroX array
by: Barber, Imelda S., et al.
Published: (2017)