Acinar cell carcinoma of exocrine pancreas in two horses
Two horses were presented with non-specific clinical signs of several weeks' duration and were humanely destroyed due to a poor prognosis. At necropsy examination, both horses had multiple small, white nodules replacing pancreatic tissue and involving the serosal surface of the abdominal cavity...
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| Format: | Article |
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Elsevier
2014
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| Online Access: | https://eprints.nottingham.ac.uk/38086/ |
| _version_ | 1848795594446864384 |
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| author | de Brot, Simone Junge, Hannah Hilbe, Monika |
| author_facet | de Brot, Simone Junge, Hannah Hilbe, Monika |
| author_sort | de Brot, Simone |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Two horses were presented with non-specific clinical signs of several weeks' duration and were humanely destroyed due to a poor prognosis. At necropsy examination, both horses had multiple small, white nodules replacing pancreatic tissue and involving the serosal surface of the abdominal cavity, the liver and the lung. Microscopically, neoplastic cells were organized in acini and contained abundant (case 1) or sparse (horse 2) intracytoplasmic zymogen granules. Immunohistochemically, both tumours expressed amylase and pan-cytokeratin, but not insulin or neuron-specific enolase. In case 2, a low percentage of neoplastic cells expressed glucagon and synaptophysin. The presence of zymogen granules was confirmed in both cases by electron microscopy and occasional fibrillary or glucagon granules were observed in cases 1 and 2, respectively. A diagnosis of pancreatic acinar cell carcinoma was established in both horses. |
| first_indexed | 2025-11-14T19:34:34Z |
| format | Article |
| id | nottingham-38086 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:34:34Z |
| publishDate | 2014 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-380862020-05-04T16:47:27Z https://eprints.nottingham.ac.uk/38086/ Acinar cell carcinoma of exocrine pancreas in two horses de Brot, Simone Junge, Hannah Hilbe, Monika Two horses were presented with non-specific clinical signs of several weeks' duration and were humanely destroyed due to a poor prognosis. At necropsy examination, both horses had multiple small, white nodules replacing pancreatic tissue and involving the serosal surface of the abdominal cavity, the liver and the lung. Microscopically, neoplastic cells were organized in acini and contained abundant (case 1) or sparse (horse 2) intracytoplasmic zymogen granules. Immunohistochemically, both tumours expressed amylase and pan-cytokeratin, but not insulin or neuron-specific enolase. In case 2, a low percentage of neoplastic cells expressed glucagon and synaptophysin. The presence of zymogen granules was confirmed in both cases by electron microscopy and occasional fibrillary or glucagon granules were observed in cases 1 and 2, respectively. A diagnosis of pancreatic acinar cell carcinoma was established in both horses. Elsevier 2014-05-31 Article PeerReviewed de Brot, Simone, Junge, Hannah and Hilbe, Monika (2014) Acinar cell carcinoma of exocrine pancreas in two horses. Journal of Comparative Pathology, 150 (4). pp. 388-392. ISSN 1532-3129 electron microscopy; fibrillary granules; immunohistochemistry; pancreas http://www.sciencedirect.com/science/article/pii/S0021997514000048 doi:10.1016/j.jcpa.2014.01.003 doi:10.1016/j.jcpa.2014.01.003 |
| spellingShingle | electron microscopy; fibrillary granules; immunohistochemistry; pancreas de Brot, Simone Junge, Hannah Hilbe, Monika Acinar cell carcinoma of exocrine pancreas in two horses |
| title | Acinar cell carcinoma of exocrine pancreas in two horses |
| title_full | Acinar cell carcinoma of exocrine pancreas in two horses |
| title_fullStr | Acinar cell carcinoma of exocrine pancreas in two horses |
| title_full_unstemmed | Acinar cell carcinoma of exocrine pancreas in two horses |
| title_short | Acinar cell carcinoma of exocrine pancreas in two horses |
| title_sort | acinar cell carcinoma of exocrine pancreas in two horses |
| topic | electron microscopy; fibrillary granules; immunohistochemistry; pancreas |
| url | https://eprints.nottingham.ac.uk/38086/ https://eprints.nottingham.ac.uk/38086/ https://eprints.nottingham.ac.uk/38086/ |