Histopathological subgroups in knee osteoarthritis
Objective: Osteoarthritis (OA) is a heterogeneous, multi-tissue disease. We hypothesised that different histopathological features characterise different stages during knee OA progression, and that discrete subgroups can be defined based on validated measures of OA histopathological features. Des...
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Elsevier
2016
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| Online Access: | https://eprints.nottingham.ac.uk/38082/ |
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| author | Wyatt, L.A. Morerton, B.J. Mapp, Paul I. Wilson, D. Hill, R. Ferguson, Eamonn Scammell, Brigitte E. Walsh, David A. |
| author_facet | Wyatt, L.A. Morerton, B.J. Mapp, Paul I. Wilson, D. Hill, R. Ferguson, Eamonn Scammell, Brigitte E. Walsh, David A. |
| author_sort | Wyatt, L.A. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Objective: Osteoarthritis (OA) is a heterogeneous, multi-tissue disease. We hypothesised that different histopathological features characterise different stages during knee OA progression, and that discrete subgroups can be defined based on validated measures of OA histopathological features.
Design: Medial tibial plateaux and synovium were from 343 post-mortem (PM) and 143 OA arthroplasty donations. A ‘chondropathy/osteophyte’ group (n = 217) was classified as PM cases with osteophytes or macroscopic medial tibiofemoral chondropathy lesions ≥grade 3 to represent pre-surgical (early) OA. ‘Non-arthritic’ controls (n = 48) were identified from the remaining PM cases. Mankin histopathological scores were subjected to Rasch analysis and supplemented with histopathological scores for subchondral bone marrow replacement and synovitis. Item weightings were derived by principle components analysis (PCA). Histopathological subgroups were sought using latent class analysis (LCA).
Results: Chondropathy, synovitis and osteochondral pathology were each associated with OA at arthroplasty, but each was also identified in some ‘non-arthritic’ controls. Tidemark breaching in the chondropathy/osteophyte group was greater than in non-arthritic controls. Three histopathological subgroups were identified, characterised as ‘mild OA’, or ‘severe OA’ with mild or moderate/severe synovitis.
Conclusions: Presence and severity of synovitis helps define distinct histopathological OA subgroups. The absence of a discrete ‘normal’ subgroup indicates a pathological continuum between normality and OA status. Identifying specific pathological processes and their clinical correlates in OA subgroups has potential to accelerate the development of more effective therapies. |
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| format | Article |
| id | nottingham-38082 |
| institution | University of Nottingham Malaysia Campus |
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| last_indexed | 2025-11-14T19:34:33Z |
| publishDate | 2016 |
| publisher | Elsevier |
| recordtype | eprints |
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| spelling | nottingham-380822020-04-29T15:34:18Z https://eprints.nottingham.ac.uk/38082/ Histopathological subgroups in knee osteoarthritis Wyatt, L.A. Morerton, B.J. Mapp, Paul I. Wilson, D. Hill, R. Ferguson, Eamonn Scammell, Brigitte E. Walsh, David A. Objective: Osteoarthritis (OA) is a heterogeneous, multi-tissue disease. We hypothesised that different histopathological features characterise different stages during knee OA progression, and that discrete subgroups can be defined based on validated measures of OA histopathological features. Design: Medial tibial plateaux and synovium were from 343 post-mortem (PM) and 143 OA arthroplasty donations. A ‘chondropathy/osteophyte’ group (n = 217) was classified as PM cases with osteophytes or macroscopic medial tibiofemoral chondropathy lesions ≥grade 3 to represent pre-surgical (early) OA. ‘Non-arthritic’ controls (n = 48) were identified from the remaining PM cases. Mankin histopathological scores were subjected to Rasch analysis and supplemented with histopathological scores for subchondral bone marrow replacement and synovitis. Item weightings were derived by principle components analysis (PCA). Histopathological subgroups were sought using latent class analysis (LCA). Results: Chondropathy, synovitis and osteochondral pathology were each associated with OA at arthroplasty, but each was also identified in some ‘non-arthritic’ controls. Tidemark breaching in the chondropathy/osteophyte group was greater than in non-arthritic controls. Three histopathological subgroups were identified, characterised as ‘mild OA’, or ‘severe OA’ with mild or moderate/severe synovitis. Conclusions: Presence and severity of synovitis helps define distinct histopathological OA subgroups. The absence of a discrete ‘normal’ subgroup indicates a pathological continuum between normality and OA status. Identifying specific pathological processes and their clinical correlates in OA subgroups has potential to accelerate the development of more effective therapies. Elsevier 2016-10-06 Article PeerReviewed Wyatt, L.A., Morerton, B.J., Mapp, Paul I., Wilson, D., Hill, R., Ferguson, Eamonn, Scammell, Brigitte E. and Walsh, David A. (2016) Histopathological subgroups in knee osteoarthritis. Osteoarthritis and Cartilage, 25 (1). pp. 14-22. ISSN 1522-9653 Osteoarthritis; Early osteoarthritis; Synovitis; Cartilage; Bone; Phenotype http://www.sciencedirect.com/science/article/pii/S1063458416303077 doi:10.1016/j.joca.2016.09.021 doi:10.1016/j.joca.2016.09.021 |
| spellingShingle | Osteoarthritis; Early osteoarthritis; Synovitis; Cartilage; Bone; Phenotype Wyatt, L.A. Morerton, B.J. Mapp, Paul I. Wilson, D. Hill, R. Ferguson, Eamonn Scammell, Brigitte E. Walsh, David A. Histopathological subgroups in knee osteoarthritis |
| title | Histopathological subgroups in knee osteoarthritis |
| title_full | Histopathological subgroups in knee osteoarthritis |
| title_fullStr | Histopathological subgroups in knee osteoarthritis |
| title_full_unstemmed | Histopathological subgroups in knee osteoarthritis |
| title_short | Histopathological subgroups in knee osteoarthritis |
| title_sort | histopathological subgroups in knee osteoarthritis |
| topic | Osteoarthritis; Early osteoarthritis; Synovitis; Cartilage; Bone; Phenotype |
| url | https://eprints.nottingham.ac.uk/38082/ https://eprints.nottingham.ac.uk/38082/ https://eprints.nottingham.ac.uk/38082/ |