Histologic, immunohistochemical, and electron microscopic characterization of a malignant iridophoroma in a dwarf bearded dragon (Pogona henrylawsoni)
A dwarf bearded dragon (Pogona henrylawsoni) was presented with a whitish subcutaneous mandibular mass and multiple nodules in the oral mucosa, heart, liver, kidney, intestine and visceral fat. Histologically, the tumor consisted of densely packed spindle-shaped cells with brownish intracytoplasmic...
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American Association of Zoo Veterinarians
2015
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| Online Access: | https://eprints.nottingham.ac.uk/38062/ |
| _version_ | 1848795589391679488 |
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| author | de Brot, Simone Sydler, Titus Nufer, Lisbeth Ruetten, Maja |
| author_facet | de Brot, Simone Sydler, Titus Nufer, Lisbeth Ruetten, Maja |
| author_sort | de Brot, Simone |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | A dwarf bearded dragon (Pogona henrylawsoni) was presented with a whitish subcutaneous mandibular mass and multiple nodules in the oral mucosa, heart, liver, kidney, intestine and visceral fat. Histologically, the tumor consisted of densely packed spindle-shaped cells with brownish intracytoplasmic pigment that exhibited white-bluish birefringence with polarized light. Immunohistochemical staining was negative for S-100 and weakly positive with Melan A. Negative contrast electron microscopic examination revealed cytoplasmic irregular, oblong empty spaces, laminated and often arranged into short stacks, compatible with reflecting platelet profiles typically seen in iridophores. However, in unstained ultrathin sections, electron dense crystalline material was present which filled the empty spaces described for stained sections before. Based on histology, immunohistochemistry and biological behavior, a malignant iridophoroma was diagnosed. To the authors’ knowledge, iridophoromas in lizards have not been characterized before by using electronic microscopy. Moreover, this is the first description of an iridophoroma in a dwarf bearded dragon. |
| first_indexed | 2025-11-14T19:34:29Z |
| format | Article |
| id | nottingham-38062 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:34:29Z |
| publishDate | 2015 |
| publisher | American Association of Zoo Veterinarians |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-380622020-05-04T17:14:18Z https://eprints.nottingham.ac.uk/38062/ Histologic, immunohistochemical, and electron microscopic characterization of a malignant iridophoroma in a dwarf bearded dragon (Pogona henrylawsoni) de Brot, Simone Sydler, Titus Nufer, Lisbeth Ruetten, Maja A dwarf bearded dragon (Pogona henrylawsoni) was presented with a whitish subcutaneous mandibular mass and multiple nodules in the oral mucosa, heart, liver, kidney, intestine and visceral fat. Histologically, the tumor consisted of densely packed spindle-shaped cells with brownish intracytoplasmic pigment that exhibited white-bluish birefringence with polarized light. Immunohistochemical staining was negative for S-100 and weakly positive with Melan A. Negative contrast electron microscopic examination revealed cytoplasmic irregular, oblong empty spaces, laminated and often arranged into short stacks, compatible with reflecting platelet profiles typically seen in iridophores. However, in unstained ultrathin sections, electron dense crystalline material was present which filled the empty spaces described for stained sections before. Based on histology, immunohistochemistry and biological behavior, a malignant iridophoroma was diagnosed. To the authors’ knowledge, iridophoromas in lizards have not been characterized before by using electronic microscopy. Moreover, this is the first description of an iridophoroma in a dwarf bearded dragon. American Association of Zoo Veterinarians 2015-09-01 Article PeerReviewed de Brot, Simone, Sydler, Titus, Nufer, Lisbeth and Ruetten, Maja (2015) Histologic, immunohistochemical, and electron microscopic characterization of a malignant iridophoroma in a dwarf bearded dragon (Pogona henrylawsoni). Journal of Zoo and Wildlife Medicine, 46 (3). pp. 583-587. ISSN 1937-2825 Chromatophoroma Dwarf bearded dragon Electron microscopy Iridophoroma Pogona henrylawsoni http://www.bioone.org/doi/10.1638/2013-0113.1 doi:10.1638/2013-0113.1 doi:10.1638/2013-0113.1 |
| spellingShingle | Chromatophoroma Dwarf bearded dragon Electron microscopy Iridophoroma Pogona henrylawsoni de Brot, Simone Sydler, Titus Nufer, Lisbeth Ruetten, Maja Histologic, immunohistochemical, and electron microscopic characterization of a malignant iridophoroma in a dwarf bearded dragon (Pogona henrylawsoni) |
| title | Histologic, immunohistochemical, and electron microscopic characterization of a malignant iridophoroma in a dwarf bearded dragon (Pogona henrylawsoni) |
| title_full | Histologic, immunohistochemical, and electron microscopic characterization of a malignant iridophoroma in a dwarf bearded dragon (Pogona henrylawsoni) |
| title_fullStr | Histologic, immunohistochemical, and electron microscopic characterization of a malignant iridophoroma in a dwarf bearded dragon (Pogona henrylawsoni) |
| title_full_unstemmed | Histologic, immunohistochemical, and electron microscopic characterization of a malignant iridophoroma in a dwarf bearded dragon (Pogona henrylawsoni) |
| title_short | Histologic, immunohistochemical, and electron microscopic characterization of a malignant iridophoroma in a dwarf bearded dragon (Pogona henrylawsoni) |
| title_sort | histologic, immunohistochemical, and electron microscopic characterization of a malignant iridophoroma in a dwarf bearded dragon (pogona henrylawsoni) |
| topic | Chromatophoroma Dwarf bearded dragon Electron microscopy Iridophoroma Pogona henrylawsoni |
| url | https://eprints.nottingham.ac.uk/38062/ https://eprints.nottingham.ac.uk/38062/ https://eprints.nottingham.ac.uk/38062/ |