The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands
The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb, http://www.guidetopharmacology.org) provides expert-curated molecular interactions between successful and potential drugs and their targets in the human genome. Developed by the International Union of Basic and Clinical Pharmacology (IUPHAR) and the Brit...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
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Oxford University Press
2016
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| Online Access: | https://eprints.nottingham.ac.uk/38018/ |
| _version_ | 1848795580649701376 |
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| author | Southan, Christopher Sharman, Joanna L. Benson, Helen E. Faccenda, Elena Pawson, Adam J. Alexander, Stephen P.H. Buneman, O. Peter Davenport, Anthony P. McGrath, John C. Peters, John A. Spedding, Michael Catterall, William A. Fabbro, Doriano Davies, Jamie A. |
| author_facet | Southan, Christopher Sharman, Joanna L. Benson, Helen E. Faccenda, Elena Pawson, Adam J. Alexander, Stephen P.H. Buneman, O. Peter Davenport, Anthony P. McGrath, John C. Peters, John A. Spedding, Michael Catterall, William A. Fabbro, Doriano Davies, Jamie A. |
| author_sort | Southan, Christopher |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb, http://www.guidetopharmacology.org) provides expert-curated molecular interactions between successful and potential drugs and their targets in the human genome. Developed by the International Union of Basic and Clinical Pharmacology (IUPHAR) and the British Pharmacological Society (BPS), this resource, and its earlier incarnation as IUPHAR-DB, is described in our 2014 publication. This update incorporates changes over the intervening seven database releases. The unique model of content capture is based on established and new target class subcommittees collaborating with in-house curators. Most information comes from journal articles, but we now also index kinase cross-screening panels. Targets are specified by UniProtKB IDs. Small molecules are defined by PubChem Compound Identifiers (CIDs); ligand capture also includes peptides and clinical antibodies. We have extended the capture of ligands and targets linked via published quantitative binding data (e.g. Ki, IC50 or Kd). The resulting pharmacological relationship network now defines a data-supported druggable genome encompassing 7% of human proteins. The database also provides an expanded substrate for the biennially published compendium, the Concise Guide to PHARMACOLOGY. This article covers content increase, entity analysis, revised curation strategies, new website features and expanded download options. |
| first_indexed | 2025-11-14T19:34:21Z |
| format | Article |
| id | nottingham-38018 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:34:21Z |
| publishDate | 2016 |
| publisher | Oxford University Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-380182020-05-04T17:33:51Z https://eprints.nottingham.ac.uk/38018/ The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands Southan, Christopher Sharman, Joanna L. Benson, Helen E. Faccenda, Elena Pawson, Adam J. Alexander, Stephen P.H. Buneman, O. Peter Davenport, Anthony P. McGrath, John C. Peters, John A. Spedding, Michael Catterall, William A. Fabbro, Doriano Davies, Jamie A. The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb, http://www.guidetopharmacology.org) provides expert-curated molecular interactions between successful and potential drugs and their targets in the human genome. Developed by the International Union of Basic and Clinical Pharmacology (IUPHAR) and the British Pharmacological Society (BPS), this resource, and its earlier incarnation as IUPHAR-DB, is described in our 2014 publication. This update incorporates changes over the intervening seven database releases. The unique model of content capture is based on established and new target class subcommittees collaborating with in-house curators. Most information comes from journal articles, but we now also index kinase cross-screening panels. Targets are specified by UniProtKB IDs. Small molecules are defined by PubChem Compound Identifiers (CIDs); ligand capture also includes peptides and clinical antibodies. We have extended the capture of ligands and targets linked via published quantitative binding data (e.g. Ki, IC50 or Kd). The resulting pharmacological relationship network now defines a data-supported druggable genome encompassing 7% of human proteins. The database also provides an expanded substrate for the biennially published compendium, the Concise Guide to PHARMACOLOGY. This article covers content increase, entity analysis, revised curation strategies, new website features and expanded download options. Oxford University Press 2016-01-04 Article PeerReviewed Southan, Christopher, Sharman, Joanna L., Benson, Helen E., Faccenda, Elena, Pawson, Adam J., Alexander, Stephen P.H., Buneman, O. Peter, Davenport, Anthony P., McGrath, John C., Peters, John A., Spedding, Michael, Catterall, William A., Fabbro, Doriano and Davies, Jamie A. (2016) The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. Nucleic Acids Research, 44 (D1). D1054-D1068. ISSN 1362-4962 http://nar.oxfordjournals.org/content/44/D1/D1054 doi:10.1093/nar/gkv1037 doi:10.1093/nar/gkv1037 |
| spellingShingle | Southan, Christopher Sharman, Joanna L. Benson, Helen E. Faccenda, Elena Pawson, Adam J. Alexander, Stephen P.H. Buneman, O. Peter Davenport, Anthony P. McGrath, John C. Peters, John A. Spedding, Michael Catterall, William A. Fabbro, Doriano Davies, Jamie A. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands |
| title | The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands |
| title_full | The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands |
| title_fullStr | The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands |
| title_full_unstemmed | The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands |
| title_short | The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands |
| title_sort | iuphar/bps guide to pharmacology in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands |
| url | https://eprints.nottingham.ac.uk/38018/ https://eprints.nottingham.ac.uk/38018/ https://eprints.nottingham.ac.uk/38018/ |