Inhibition of Rho-kinase protects cerebral barrier from ischaemia-evoked injury through modulations of endothelial cell oxidative stress and tight junctions

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Inhibition of Rho-kinase protects cerebral barrier from ischaemia-evoked injury through modulations of endothelial cell oxidative stress and tight junctions

Ischaemic strokes evoke blood–brain barrier (BBB) disruption and oedema formation through a series of mechanisms involving Rho-kinase activation. Using an animal model of human focal cerebral ischaemia, this study assessed and confirmed the therapeutic potential of Rho-kinase inhibition during the a...

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Bibliographic Details
Main Authors:	Gibson, Claire L., Srivastava, Kirtiman, Sprigg, Nikola, Bath, Philip M.W., Bayrakutan, Ulvi
Format:	Article
Published:	Wiley 2014
Online Access:	https://eprints.nottingham.ac.uk/38002/

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